Patents by Inventor Takashi IZUHARA

Takashi IZUHARA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Form of isoquinoline sulfonamide
    Patent number: 11427546
    Abstract: A stable crystal of a salt of N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide may have desirable properties for a pharmaceutical drug substance, and more specifically N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide dihydrochloride anhydride. A crystal of the anhydride may have characteristic peaks at 2? angles of 6.8±0.1°, 10.0±0.1°, 12.7±0.1°, 14.6±0.1°, 14.8±0.1°, 16.2±0.1°, 17.4±0.1°, 17.8±0.1°, 19.5±0.1°, 20.0±0.1°, 21.6±0.1°, 24.7±0.1°, 25.5±0.1°, 25.8±0.1°, 29.8±0.1°, 39.5±0.1°, and/or 44.9±0.1° in powder X-ray diffraction spectrum.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: August 30, 2022
    Assignee: D. WESTERN THERAPEUTICS INSTITUTE, INC.
    Inventors: Hiroyoshi Hidaka, Kengo Sumi, Takashi Izuhara
  • NEW FORM OF ISOQUINOLINE SULFONAMIDE
    Publication number: 20220017469
    Abstract: A stable crystal of a salt of N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide may have desirable properties for a pharmaceutical drug substance, and more specifically N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide dihydrochloride anhydride. A crystal of the anhydride may have characteristic peaks at 2? angles of 6.8±0.1°, 10.0±0.10, 12.7±0.10, 14.6±0.1°, 14.8±0.1°, 16.2±0.1°, 17.4±0.1°, 17.8±0.1°, 19.5±0.1°, 20.0±0.1°, 21.6±0.1°, 24.7±0.10, 25.5±0.1°, 25.8±0.1°, 29.8-0.1°, 39.5-0.1°, and/or 44.9±0.1° in powder X-ray diffraction spectrum.
    Type: Application
    Filed: December 16, 2019
    Publication date: January 20, 2022
    Applicant: D. WESTERN THERAPEUTICS INSTITUTE, INC.
    Inventors: Hiroyoshi HIDAKA, Kengo SUMI, Takashi IZUHARA