Abstract: A scavenger receptor A expression down-regulator and a drug for preventing or treating arteriosclerosis which contain, as the active ingredient, a C-terminal globular domain of adiponectin, adiponectin, or a gene encoding the domain or adiponectin. According to the present invention, there is provided a preventive or therapeutic agent capable of directly preventing intimal thickening, which constitutes an essential feature of arteriosclerosis. This effect can be attained through arresting the onset and development of arteriosclerosis by reducing the expression level of scavenger receptor A in arterial walls and preventing lipid buildup in macrophages.

Abstract: An electromagnet a coil, a movable iron core adapted to move on the center axis of the coil, and a stationary iron core provided so as to cover the upper and lower surfaces and the outer peripheral surface of the coil. A permanent magnet is arranged in a gap surrounded by the movable iron core and the stationary core.

Abstract: The duct comprises the upper member and the lower member, which are formed separately and assembled integrally by being attached to one another. There is provided the seal member to interconnect the opening at the lower member and the intercooler, which is pressed against the upper face of the intercooler. The front side of the lower member is supported at the shroud panel, and the rear side of the upper panel is supported at the cowl panel. Thus, the rear attachment portion is detached earlier than the front attachment portion at the pedestrian's hit. Accordingly, the duct can be split surely and the engine hood can be allowed to be properly deformed without being prevented, so that the protection of the head of pedestrians can be attained properly.

Abstract: The animals of the present invention enable elucidation of the onset mechanisms of obesity, diabetes, and arteriosclerosis. Moreover, they are useful for screening preventive and therapeutic drugs for treating any of these diseases.

Abstract: An electromagnet includes a coil, a movable iron core adapted to move on the center axis of the coil, and a stationary iron core provided so as to cover the upper and lower surfaces and the outer peripheral surface of the coil. A permanent magnet is arranged in a gap surrounded by the movable iron core and the stationary core.

Abstract: It is an objective of the present invention to provide a novel method of ameliorating leptin resistance. In order to achieve the above objective, the present invention provides a method of ameliorating leptin resistance in a patient, which comprises a process of administering a &bgr;3 adrenergic receptor agonist to the patient with leptin resistance.

Abstract: The object is to isolate and identify human and mouse adiponectin receptors, to provide a novel protein having adiponectin binding ability, and to provide a screening method and screening kit for a ligand, agonist and antagonist to an adiponectin receptor using such protein. To achieve this object, a protein is used, as novel protein having adiponectin binding ability, that is (a) a protein comprising an amino acid sequence according to Seq. No. 2, 4, 6 or 8, or (b) a protein comprising an amino acid sequence according to Seq. No. 2, 4, 6 or 8 with one or more amino acids deleted, replaced or added, and having adiponectin binding ability.

Abstract: An electromagnet includes a coil, a movable iron core adapted to move on the center axis of the coil, and a stationary iron core provided so as to cover the upper and lower surfaces and the outer peripheral surface of the coil. A permanent magnet is arranged in a gap surrounded by the movable iron core and the stationary core.

Abstract: An electromagnet includes a coil, a movable iron core adapted to move on the center axis of the coil, and a stationary iron core provided so as to cover the upper and lower surfaces and the outer peripheral surface of the coil. A permanent magnet is arranged in a gap surrounded by the movable iron core and the stationary core.

Abstract: An electromagnet composed of a coil, a movable iron core adapted to move on the center axis of the coil, and a stationary iron core provided so as to cover the upper and lower surfaces and the outer peripheral surface of the coil, characterized by a permanent magnet arranged in a gap surrounded by the movable iron core and the stationary core, wherein the movable iron core is attracted by the stationary iron core by a magnetic field created by the permanent magnet, thereby it is possible to solve a problem inherent to a conventional electromagnet such that a permanent magnet is directly energized in a reverse direction during release operation so as to cause demagnetization of the permanent magnet.

Abstract: The invention creates a very high-novelty medicinal drug for the carbohydrate and lipid metabolism-related diseases by finding out an inhibitory substance or antagonist against PPAR &agr; and PPAR &ggr;, and relates to an application of fatty acid CoA thioester that was found out as an active inhibitory substance against peroxisome proliferator-activated receptor &agr; and &ggr; (hereinafter referred to as PPARs) to the assay of medicinal drug, and a use of fatty acid CoA thioester for medicinal drug.

Abstract: An electromagnet composed of a coil, a movable iron core adapted to move on the center axis of the coil, and a stationary iron core provided so as to cover the upper and lower surfaces and the outer peripheral surface of the coil, characterized by a permanent magnet arranged in a gap surrounded by the movable iron core and the stationary core, wherein the movable iron core is attracted by the stationary iron core by a magnetic field created by the permanent magnet, thereby it is possible to solve a problem inherent to a conventional electromagnet such that a permanent magnet is directly energized in a reverse direction during release operation so as to cause demagnetization of the permanent magnet.

Abstract: A silver halide photographic light-sensitive material is disclosed. The light-sensitive material comprises a support having thereon a photographic layer including a silver halide emulsion layer wherein the outermost surface of said photographic layer has a pH value of from 5.4 to 5.9 and said silver emulsion layer contains a compound represented by the following formula I; ##STR1## wherein R.sub.1 is an alkyl group, a cycloalkyl group or an aryl group; R.sub.2 is an alkyl group, a cycloalkyl group, an acyl group or an aryl group; R.sub.3 is a substituent, n is 0 or 1; X.sub.1 is a substituent capable of splitting off upon coupling reaction with the oxidation product of a color developing agent; and Y.sub.1 is an organic group. The light-sensitive material is excellent in stability during storage and gives stable photographic characteristics even when pH value of developer is varied.

Abstract: A silver halide color photographic light-sensitive material is disclosed. The light-sensitive material comprises a support having thereon a photographic layer includinga silver halide emulsion layer comprising silver halide grains and a binder and a specific pyrazolone type magenta coupler,a non-light-sensitive layer comprising a binder and a compound of Formula II being a liquid at 15.degree. C., and provided adjacently to the surface of said silver halide emulsion layer closer to sais support, anda layer provided at the outermost position of said photographic layer containing a compound represented by Formula II; ##STR1## wherein R.sub.11 and R.sub.12 are each a secondary or tertiary alkyl group and a number of carbon atoms Contained in the groups represented by R.sub.11 and R.sub.12 is 20 or more in total.

Abstract: There is disclosed a method for forming a dye image which comprises a step of processing, with a color developing solution, a photo-sensitive silver halide photographic material comprising a support having thereon a silver halide emulsion layer. The method is characterized in that said silver halide emulsion layer comprises silver halide grains having a silver chloride content of not less than 90 mol. %; said photosensitive silver halide photographic material comprises a white pigment in an amount of not less than 3.5 g per m.sup.2 of said photographic material; and said photosensitive silver halide photographic material is, after being processed with the color developing solution, processed with a bleaching solution (BL-1) and subsequently with a fixing solution.

Abstract: A silver halide photographic light-sensitive material which contains, on a support, a compound represented by the following Formula [I]: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclic, alkoxy, aryloxy, alkylamino or arylamino;R.sub.2 is hydrogen, halogen, alkyl or alkoxy;R.sub.3 is alkyl, cycloalkyl or aryl; or R.sub.2 and R.sub.3 may be bonded together to form a 5- or 6-membered ring condensed to the phenolic ring; andZ is hydrogen or a group releasable by the coupling reaction with the oxidation product of an organic primary amine color developing agent,and a compound represented by the following Formula [II]: ##STR2## where R.sub.4 and R.sub.5 are alkyl, aryl, --COOH', --COOR', --OR', --NR', --NR'R", --CN, --NHCOR', --NHCONHR', or --CONHR', where R' and R" are alkyl or aryl; andR.sub.6 and R.sub.7 are alkyl or aryl containing at least one carboxy group or sulfonic acid group.

Abstract: A silver halide photographic material is disclosed which has formed on a support in sequence a silver halide emulsion layer incorporating a yellow coupler of the formula (I), a silver halide emulsion layer incorporating a magenta coupler of the formula (II), and a silver halide emulsion layer incorporating a cyan coupler of the formula (III): ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom or an alkoxy group; R.sub.2 is --NHCOR.sub.3, --NHSO.sub.2 R.sub.3, --COOR.sub.3 or ##STR2## provided that R.sub.3 and R.sub.4 are each an alkyl group; and Z.sub.1 is a non-metallic atomic group necessary to form a 5- or 6-membered hetero ring together with a nitrogen atom); ##STR3## [wherein R.sub.5 is a hydrogen atom, a halogen atom or an alkoxy group having 1 to 4 carbon atoms; R.sub.6 is (provided that R.sub.7 and R.sub.8 are each a hydrogen atom or an acyl group, and when R.sub.7 and R.sub.

Abstract: A silver halide photographic material having one or more silver halide emulsion layers formed on a support is disclosed wherein at least one of said silver halide emulsion layers contains at least one cyan coupler of formula (I) dispersed therein with the aid of a high-boiling organic solvent having a dielectric constant of not more than 6.0: ##STR1## (wherein R.sub.1 is a straight- or branched-chain alkyl group having 2 or 4 carbon atoms; X is a hydrogen atom or a group capable of leaving upon coupling reaction; and R.sub.2 is a ballast group).

Abstract: A silver halide photographic light-sensitive material is disclosed, which is excellent in light discoloration resistance and is more particularly capable of keeping its color balance and reproducing long life color images. The photographic material comprises a support, at least three light-sensitive silver halide emulsion layers containing a yellow, magenta, and cyan coupler, respectively, and at least one non-light-sensitive layer being provided at a further side of the emulsion layer being provided at the furthest position from the support. The non-light-sensitive layer contains at least three kinds of UV absorbers represented by the general formula [UV-I], provided that at least one of the UV absorbers is in a liquid state at 30.degree. C. and at least two UV absorbers are in a solid state at the same temperature.

Abstract: A silver halide light-sensitive material having a support and at least one silver halide emulsion is provided. The silver halide emulsion layer contains in combination at least one cyan coupler of Formula (I) and at least one cyan coupler of Formula (II).