Abstract: Wound bed preparation in a skin wound area can be carried out by using a hydrogel sheet, wherein the hydrogel sheet is prepared by spreading a hydrogel containing a water-soluble polymer, glycerin, and water on a two-layered laminated film consisting of a polyurethane film and a hydrophobic fiber and the moisture permeability of the hydrogel sheet is 200-2000 (g/m2/24 h).

Abstract: Provided is a transdermal absorption-type patch containing a serotonin receptor antagonist, which has a short transdermal absorption delay time (lag time), and in which the maximum transdermal permeation rate of the drug can be reached within a short time and the drug can disappear from circulating blood rapidly. That is, provided is a patch containing a serotonin receptor antagonist, wherein the patch contains an adhesive layer comprising a non-functional acrylic adhesive, a water-soluble organic amine, a fatty acid ester, and a serotonin receptor antagonist such as granisetron as an active ingredient.

Abstract: An aqueous patch containing diclofenac sodium, wherein the patch contains a homogeneous mixed solution of diclofenac sodium, wherein the solution is obtained by mixing crotamiton, diclofenac sodium and water in the mixture ratio of crotamiton/diclofenac sodium of 8.0 or less and the mixture ratio of (water+crotamiton)/diclofenac sodium of 3.0-20.0.

Abstract: Provided is a water-based plaster in which the gel strength is maintained to an appropriate level in a step of producing the water-based plaster, and particularly in a spreading step and an aging step, and a final preparation can exhibit an optimal adhesiveness for adhering to the skin. In the water-based plaster, a water-based adhesive base containing a water-soluble polymer as a main ingredient contains a higher fatty acid which is a liquid at room temperature and a viscosity of 1,000 (mPa·s, 20° C.) or more as a crosslinking modifier. The higher fatty acid is isostearic acid, and the contained amount thereof is 1 to 10% by weight.

Abstract: Provided is a transdermal absorption-type patch containing a serotonin receptor antagonist, which has a short transdermal absorption delay time (lag time), and in which the maximum transdermal permeation rate of the drug can be reached within a short time and the drug can disappear from circulating blood rapidly. That is, provided is a patch containing a serotonin receptor antagonist, wherein the patch contains an adhesive layer comprising a non-functional acrylic adhesive, a water-soluble organic amine, a fatty acid ester, and a serotonin receptor antagonist such as granisetron as an active ingredient.

Abstract: Provided is a water-based plaster in which the gel strength is maintained to an appropriate level in a step of producing the water-based plaster, and particularly in a spreading step and an aging step, and a final preparation can exhibit an optimal adhesiveness for adhering to the skin. In the water-based plaster, a water-based adhesive base containing a water-soluble polymer as a main ingredient contains a higher fatty acid which is a liquid at room temperature and a viscosity of 1,000 (mPa·s, 20° C.) or more as a crosslinking modifier. The higher fatty acid is isostearic acid, and the contained amount thereof is 1 to 10% by weight.

Abstract: An external patch containing diclofenac hydroxyethylpyrrolidine prepared by laminating an adhesive layer on a backing, wherein said adhesive layer is characterized by comprising 5-50% by weight of styrene•isoprene•styrene block copolymer, 20-50% by weight of a tackifier resin, 5-70% by weight of a softening agent, and 0.5-20% by weight of one or more solubilizers selected from N-methyl-2-pyrrolidone, propylene glycol and dimethyl sulfoxide as essential ingredients, and 0.5-20% by weight of diclofenac hydroxyethylpyrrolidine as an active ingredient. The patch has excellent transdermal absorption, less skin-irritation and excellent stability of the drug.

Abstract: A wound-covering hydrogel material which has excellent stretchability and absorbs exudates from wounds. It can maintain over long a wet environment which is suitable for accelerating the healing of wounds. There is no fear of causing pain or damaging the regenerated skin when the wound-covering hydrogel material is replaced with a fresh one. The wound-covering hydrogel material prepared by spreading a hydrogel comprising a water-soluble semi-synthetic polymer, glycerol and water, on a laminated two-layer film composed of a polyurethane film and hydrophobic fibers. The covering material has a moisture permeability as measured by the cup method in accordance with JIS Z0208 of 500-2,000 (g/m2/24 h).

Abstract: Wound bed preparation in a skin wound area can be carried out by using a hydrogel sheet, wherein the hydrogel sheet is prepared by spreading a hydrogel containing a water-soluble polymer, glycerin, and water on a two-layered laminated film consisting of a polyurethane film and a hydrophobic fiber and the moisture permeability of the hydrogel sheet is 200-2000 (g/m2/24 h).

Abstract: An apparatus and a method for simulatively measuring an environment in a microspace between human skin and a wound dressing. The simulative environment-measuring apparatus includes a constant temperature-and-humidity chamber (14); a heat exchanger (12) disposed in the chamber; a constant temperature water bath (10) and a pump (11) for supplying warm water to the heat exchanger; and a container (1) set on the heat exchanger. The container holds a water retentive member (2) therein, and is covered with a water vapor diffusion-controlling member (4). A microspace (6) formed between the water vapor diffusion-controlling member and a wound dressing (5) is a simulatively reproduced space between human skin and the wound dressing. A thin temperature-and-humidity sensor (7) is set in the microspace to measure temperature and humidity. When plural containers are used, the environments of plural wound dressings can be measured at once.

Abstract: Disclosed is a water-based adhesive skin patch which has excellent storage stability, can achieve excellent accumulation of butenafine hydrochloride contained therein on a patched area such as the skin and a nail, and has a high therapeutic effect. Specifically disclosed is a water-based adhesive skin patch containing butenafine hydrochloride, which is characterized by containing butenafine hydrochloride, glycol salicylate and propylene glycol in a water-containing gel ointment. Specifically, butenafine hydrochloride is dissolved in a mixed solution of glycol salicylate and propylene glycol, and the resulting solution is dispersed in a water-containing gel. Particularly, the mixing ratio of glycol salicylate to propylene glycol is 1:2 to 1:30.

Abstract: An external patch containing diclofenac hydroxyethylpyrrolidine prepared by laminating an adhesive layer on a backing, wherein said adhesive layer is characterized by comprising 5-50% by weight of styrene•isoprene•styrene block copolymer, 20-50% by weight of a tackifier resin, 5-70% by weight of a softening agent, and 0.5-20% by weight of one or more solubilizers selected from N-methyl-2-pyrrolidone, propylene glycol and dimethyl sulfoxide as essential ingredients, and 0.5-20% by weight of diclofenac hydroxyethylpyrrolidine as an active ingredient. The patch has excellent transdermal absorption, less skin-irritation and excellent stability of the drug.

Abstract: An aqueous patch containing diclofenac sodium, wherein the patch contains a homogeneous mixed solution of diclofenac sodium, wherein the solution is obtained by mixing crotamiton, diclofenac sodium and water in the mixture ratio of crotamiton/diclofenac sodium of 8.0 or less and the mixture ratio of (water+crotamiton)/diclofenac sodium of 3.0-20.0.

Abstract: Disclosed is a water-based adhesive skin patch which has excellent storage stability, can achieve excellent accumulation of butenafine hydrochloride contained therein on a patched area such as the skin and a nail, and has a high therapeutic effect. Specifically disclosed is a water-based adhesive skin patch containing butenafine hydrochloride, which is characterized by containing butenafine hydrochloride, glycol salicylate and propylene glycol in a water-containing gel ointment. Specifically, butenafine hydrochloride is dissolved in a mixed solution of glycol salicylate and propylene glycol, and the resulting solution is dispersed in a water-containing gel. Particularly, the mixing ratio of glycol salicylate to propylene glycol is 1:2 to 1:30.

Abstract: There are provided an apparatus and a method for simulatively measuring an environment in a microspace between a human skin and a wound dressing. The simulative environment-measuring apparatus comprises a constant temperature-and-humidity chamber 14 for controlling an external environment; a heat exchanger 12 disposed in the chamber 14; a constant temperature water bath 10 and a pump 11 for supplying warm water to the heat exchanger; and a container 1 which is set on the heat exchanger 12 and is easily detachable therefrom. The container 1 holds a water retentive member 2 therein, and is covered at its upper opening with a water vapor diffusion-controlling member 4. A microspace 6 formed between the water vapor diffusion-controlling member 4 and a wound dressing 5 placed on the member 4 is a simulatively reproduced space between a human skin and the wound dressing 5. A thin temperature-and-humidity sensor 7 is set in this microspace 6 to measure temperature and humidity with time.

Abstract: A wound-covering hydrogel material which has excellent stretchability and absorbs exudates from wounds. It can maintain over long a wet environment which is suitable for accelerating the healing of wounds. There is no fear of causing pain or damaging the regenerated skin when the wound-covering hydrogel material is replaced with a fresh one. The wound-covering hydrogel material prepared by spreading a hydrogel comprising a water-soluble semi-synthetic polymer, glycerol and water, on a laminated two-layer film composed of a polyurethane film and hydrophobic fibers. The covering material has a moisture permeability as measured by the cup method in accordance with JIS Z0208 of 500-2,000 (g/m2/24 h).

Abstract: According to the present invention, it is provided blasticidin S (hereinafter referred to as BcS) deaminase, a gene coding for the BcS deaminase, a vector incorporating the BcS deaminase gene and a transformant or a transductant transformed or transduced with the vector.It is an object of the present invention to provide BcS deaminase, a BcS deaminase gene, a vector incorporating the BcS deaminase gene and a transformant containing the vector by focusing on the fact that blasticidin S is an aminonucleoside antibiotic capable of inhibiting a protein synthesis in the wide range of organisms and is generally used as an agricultural antibiotic.It is another object of the present invention to establish expression vectors of above-mentioned BcS gene and to produce useful plants having drug resistance against specific agricultural chemicals.