Abstract: A control device for a vehicle includes an electronic control unit configured to: execute driving assistance control for driving the vehicle at least by automatically controlling a speed irrespective of a driving operation of a driver; execute regenerative braking using a rotator at a time of deceleration during travel under the driving assistance control, and to restrict downshift of an automatic transmission when a demanded deceleration amount for the vehicle is equal to or lower than a predetermined deceleration amount; and execute the regenerative braking using the rotator at the time of deceleration during the travel under the driving assistance control, and not to restrict the downshift when the demanded deceleration amount is higher than the predetermined deceleration amount.

Abstract: Input unit to which a voltage is applied, current output unit that outputs a high level current or a low level current in response to the voltage applied to input unit, and stochastic circuit unit that, in response to the voltage applied to input unit, changes a probability that the high level current or the low level current is output from current output unit, in accordance with a sigmoid function used in a mathematical model of a neural activity are included.

Abstract: Since a maximum rotation speed is set to a lower value when a supercharging pressure from a supercharger is high than when the supercharging pressure is low, an engine torque is decreased at a relatively low engine rotation speed and the engine rotation speed is less likely to fall into a high-rotation state. Since the maximum rotation speed is set to a relatively high value when the supercharging pressure is relatively low and the engine rotation speed is less likely to fall into a high-rotation state, the engine torque is not decreased at a relatively high engine rotation speed and power performance can be easily secured. Accordingly, it is possible to curb a decrease in power performance due to a decrease in the engine torque and to prevent the engine rotation speed from falling into a high-rotation state.

Abstract: A control device for a vehicle includes an electronic control unit configured to: execute driving assistance control for driving the vehicle at least by automatically controlling a speed irrespective of a driving operation of a driver; execute regenerative braking using a rotator at a time of deceleration during travel under the driving assistance control, and to restrict downshift of an automatic transmission when a demanded deceleration amount for the vehicle is equal to or lower than a predetermined deceleration amount; and execute the regenerative braking using the rotator at the time of deceleration during the travel under the driving assistance control, and not to restrict the downshift when the demanded deceleration amount is higher than the predetermined deceleration amount.

Abstract: The present invention provides a method for treating SWI/SNF complex-deficient cancers comprising a glutathione (GSH) metabolic pathway inhibitor, a pharmaceutical composition comprising a glutathione (GSH) metabolic pathway inhibitor for therapy in SWI/SNF complex-deficient cancers, and a glutathione (GSH) metabolic pathway inhibitor for use in treating SWI/SNF complex-deficient cancers. The present invention also provides a method for detecting and/or selecting a susceptible patient to a glutathione (GSH) metabolic pathway inhibitor.

Abstract: A control device for a hybrid vehicle includes an engine operating point control unit that shifts an engine operating point to an engine operating point on an optimal fuel-efficiency operating line outside a predetermined noise generation region in which combustion sounds of an engine become noise when the engine operating point is in the noise generation region. Accordingly, when the engine operating point is in the noise generation region, the engine operating point control unit shifts the engine operating point to an engine operating point on the optimal fuel-efficiency operating line outside the noise generation region. As a result, since the engine operating point is not separated from the optimal fuel-efficiency operating line even when the engine operating point departs from the noise generation region, it is possible to curb a decrease in fuel efficiency.

Abstract: When the required driving force is larger than the first upper limit driving force, the control device sets a target compensation power of a power storage device, based on a difference between the required driving force and the first upper limit driving force. Further, the control device gradually increases a working compensation power toward the target compensation power when the gear ratio of the stepped transmission is changed, compared with an increase in the working compensation power when the gear ratio of the stepped transmission is not changed.

Abstract: A control device for a hybrid vehicle includes an engine operating point control unit that shifts an engine operating point to an engine operating point on an optimal fuel-efficiency operating line outside a predetermined noise generation region in which combustion sounds of an engine become noise when the engine operating point is in the noise generation region. Accordingly, when the engine operating point is in the noise generation region, the engine operating point control unit shifts the engine operating point to an engine operating point on the optimal fuel-efficiency operating line outside the noise generation region. As a result, since the engine operating point is not separated from the optimal fuel-efficiency operating line even when the engine operating point departs from the noise generation region, it is possible to curb a decrease in fuel efficiency.

Abstract: Since a maximum rotation speed is set to a lower value when a supercharging pressure from a supercharger is high than when the supercharging pressure is low, an engine torque is decreased at a relatively low engine rotation speed and the engine rotation speed is less likely to fall into a high-rotation state. Since the maximum rotation speed is set to a relatively high value when the supercharging pressure is relatively low and the engine rotation speed is less likely to fall into a high-rotation state, the engine torque is not decreased at a relatively high engine rotation speed and power performance can be easily secured. Accordingly, it is possible to curb a decrease in power performance due to a decrease in the engine torque and to prevent the engine rotation speed from falling into a high-rotation state.

Abstract: When the required driving force is larger than the first upper limit driving force, the control device sets a target compensation power of a power storage device, based on a difference between the required driving force and the first upper limit driving force. Further, the control device gradually increases a working compensation power toward the target compensation power when the gear ratio of the stepped transmission is changed, compared with an increase in the working compensation power when the gear ratio of the stepped transmission is not changed.

Abstract: An information processing apparatus (2000) extracts a histomorphological feature of a tissue included in pathological image data (10). The information processing apparatus (2000) generates prediction data (30) based on the extracted histomorphological feature. The prediction data (30) indicates one or more of a prediction relating to an effect of a cancer therapeutic drug on a target patient and a prediction of a side effect of the cancer therapeutic drug on the target patient.

Abstract: An electronic control unit is configured to make an engine start-up threshold at a time of second operation control smaller than an engine start-up threshold at a time of first operation control. Therefore, the engine stop time at the time of the first operation control can be made long. In consequence, the vehicle efficiency can be enhanced in a vehicle in which the first operation control and the second operation control can be selectively performed.

Abstract: It has been found that CBP and p300 are in the relationship of synthetic lethality, and treatment inhibiting p300 is a promising approach for the treatment of CBP-mutated cancer. It has also been revealed that this therapeutic strategy achieves efficient treatment based on companion diagnostics because a p300 inhibitor can be administered to a cancer patient selected with functional suppression of CBP as an index.

Abstract: Input unit to which a voltage is applied, current output unit that outputs a high level current or a low level current in response to the voltage applied to input unit, and stochastic circuit unit that, in response to the voltage applied to input unit, changes a probability that the high level current or the low level current is output from current output unit, in accordance with a sigmoid function used in a mathematical model of a neural activity are included.

Abstract: An electronic control unit is configured to make an engine start-up threshold at a time of second operation control smaller than an engine start-up threshold at a time of first operation control. Therefore, the engine stop time at the time of the first operation control can be made long. In consequence, the vehicle efficiency can be enhanced in a vehicle in which the first operation control and the second operation control can be selectively performed.

Abstract: It has been found that CBP and p300 are in the relationship of synthetic lethality, and treatment inhibiting p300 is a promising approach for the treatment of CBP-mutated cancer. It has also been revealed that this therapeutic strategy achieves efficient treatment based on companion diagnostics because a p300 inhibitor can be administered to a cancer patient selected with functional suppression of CBP as an index.

Abstract: It has been found that BRG1 and BRM have a synthetic-lethal relationship, and that a treatment for inhibiting BRM is a promising approach for treating a BRG1-deficient cancer having no mutation in known therapeutic target genes. Moreover, it has also been revealed that, in this therapeutic strategy, a BRM inhibitor may be administered to a cancer patient after the selection based on BRG1 function suppression, thus enabling an efficient treatment based on the companion diagnosis.

Abstract: In order to identify a gene that can serve as an indicator for predicting the effectiveness of a drug treatment of cancer and to provide a novel method for predicting the effectiveness of a drug treatment targeting said gene, lung adenocarcinomas were subjected to whole-transcriptome sequencing. As a result, in-frame fusion transcripts between the KIF5B gene and the RET gene were identified. The KIF5B-RET gene fusions were detected in 6 out of 319 (2%) LADC specimens from Japanese individuals and 1 out of 80 (1%) LADC specimens from U.S.A. individuals. None of the seven subjects revealed known activating mutations such as EGFR, KRAS or ALK oncogenes; thus, said gene fusions were found to be responsible mutations (driver mutations) for oncogenesis. Since said gene fusions are considered to induce constitutive activation of RET tyrosine kinase protein, it was found that treatments with RET tyrosine kinase inhibitors are effective in patients with detection of said gene fusions.

Abstract: [PROBLEMS] To identify mutations that can serve as indicators for predicting the effectiveness of drug treatments in cancers such as lung cancer; to provide a means for detecting said mutations; and to provide a means for identifying, based on said mutations, patients with cancer or subjects with a risk of cancer, in which drugs targeting genes having said mutations or proteins encoded by said genes show a therapeutic effect. [MEANS FOR SOLVING] A method for detecting a gene fusion serving as a responsible mutation (driver mutation) for cancer, the method comprising the step of detecting any one of an EZR-ERBB4 fusion polynucleotide, a KIAA1468-RET fusion polynucleotide, a TRIM24-a BRAF fusion polynucleotide, a CD74-NRG1 fusion polynucleotide, and an SLC3A2-NRG1 fusion polynucleotide, or a polypeptide encoded thereby, in an isolated sample from a subject with cancer.

Abstract: In order to identify a gene that can serve as an indicator for predicting the effectiveness of a drug treatment of cancer and to provide a novel method for predicting the effectiveness of a drug treatment targeting said gene, lung adenocarcinomas were subjected to whole-transcriptome sequencing. As a result, in-frame fusion transcripts between the KIF5B gene and the RET gene were identified. The KIF5B-RET gene fusions were detected in 6 out of 319 (2%) LADC specimens from Japanese individuals and 1 out of 80 (1%) LADC specimens from U.S.A. individuals. None of the seven subjects revealed known activating mutations such as EGFR, KRAS or ALK oncogenes; thus, said gene fusions were found to be responsible mutations (driver mutations) for oncogenesis. Since said gene fusions are considered to induce constitutive activation of RET tyrosine kinase protein, it was found that treatments with RET tyrosine kinase inhibitors are effective in patients with detection of said gene fusions.