Patents by Inventor Takashi Kumasaka

Takashi Kumasaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MUTANT RAS POLYPEPTIDE CRYSTAL
    Publication number: 20120142116
    Abstract: An object of the present invention is to provide a co-crystal of a Ras polypeptide which adopts a conformation having a pocket on the molecular surface of Ras and GTP or a GTP analog, a production method for the crystal, and a screening method for a Ras function inhibitor based on information about the conformation obtained by X-ray crystallographic analysis using the crystal. The object is achieved by focusing on a mutation which adopts a conformation having a pocket on the molecular surface of Ras, acquiring a mutant Ras polypeptide having introduced therein such mutation, producing a co-crystal of the mutant Ras polypeptide and a GTP analog, and further subjecting the co-crystal to X-ray crystallographic analysis to acquire structural information about the conformation including information about the structure surrounding the pocket.
    Type: Application
    Filed: July 13, 2010
    Publication date: June 7, 2012
    Applicants: JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Tohru Kataoka, Fumi Shima, Atsuo Tamura, Takashi Kumasaka
  • THREE-DIMENSIONAL STRUCTURE OF PROSTAGLANDIN D SYNTHASE AND UTILIZATION THEREOF
    Publication number: 20090263784
    Abstract: A method of designing an anti-allergic agent, sleep controlling agent, anti-obesity agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.
    Type: Application
    Filed: January 30, 2009
    Publication date: October 22, 2009
    Inventors: Yoshihiro URADE, Osamu Hayaishi, Tsuyoshi Inoue, Yasushi Kai, Yousuke Okano, Shigehiro Kinugasa, Hiroyoshi Matsumura, Daisuke Irikura, Masaki Yamamoto, Takashi Kumasaka, Masashi Miyano
  • Three-dimensional structure of prostaglandin D synthase and utilization thereof
    Patent number: 7547532
    Abstract: A method of designing an anti-allergic agent, sleep controlling agent, anti-obestic agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: June 16, 2009
    Assignee: Japan Science and Technology Agency
    Inventors: Yoshihiro Urade, Osamu Hayaishi, Tsuyoshi Inoue, Yasushi Kai, Yousuke Okano, Shigehiro Kinugasa, Hiroyoshi Matsumura, Daisuke Irikura, Masaki Yamamoto, Takashi Kumasaka, Masashi Miyano
  • Three-dimensinal structure of prostaglandin d synthase and utilization thereof
    Publication number: 20050255576
    Abstract: It is intended to provide a method of designing an antiallergic agent, a sleep controlling agent, an antiobestic and a remedy for brain injury acting via the inhibition of the biosynthesis of prostaglandin D2. Crystals of a complex of human-origin hematopoietic prostaglandin D synthase, glutathione and a substrate analog or an inhibitor, etc. are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.
    Type: Application
    Filed: September 27, 2002
    Publication date: November 17, 2005
    Inventors: Yoshihiro Urade, Osamu Hayaishi, Tsuyoshi Inoue, Yasushi Kai, Yousuke Okano, Shigehiro Kinugasa, Hiroyoshi Matsumura, Daisuke Irikura, Masaki Yamamoto, Takashi Kumasaka, Masashi Miyano
  • Three-dimensional structure of bovine rhodopsin
    Publication number: 20020142385
    Abstract: The present invention discloses a three-dimensional structure of bovine rhodopsin.
    Type: Application
    Filed: August 3, 2001
    Publication date: October 3, 2002
    Inventors: Masashi Miyano, Takashi Kumasaka, Tetsuya Hori, Hiroyuki Motoshima, Tetsuji Okada, Masaki Yamamoto, Krzysztof Palczewski, Craig A. Behnke, Brian A. Fox, Isolde Le Trong, David C. Teller, Ronald E. Stenkamp