Patents by Inventor Takashi Moroi

Takashi Moroi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing an optically active tetrahydroquinoline
    Patent number: 8188307
    Abstract: Disclosed is an industrially advantageous production method of optically active ?-amino acid of formula (5a), which includes subjecting an enaminoester of formula (4a) to an asymmetric hydrogenation: wherein * shows an asymmetric carbon atom.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: May 29, 2012
    Assignee: Takasago International Corporation
    Inventors: Takashi Moroi, Tsukasa Sotoguchi, Kazuhiko Matsumura, Motonobu Takenaka, Wataru Kuriyama, Toshiyuki Murayama, Hideki Nara, Tohru Yokozawa, Kenji Yagi
  • METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE
    Publication number: 20100036149
    Abstract: The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a ?-ketoester of formula (2) with an amine of formula (3) to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active ?-amino acid derivative of formula (5); 3) a step of amidating the optically active ?-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) a step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).
    Type: Application
    Filed: August 31, 2009
    Publication date: February 11, 2010
    Applicant: TAKASAGO INTERNATIONAL COPORATION
    Inventors: Takashi Moroi, Tsukasa Sotoguchi, Kazuhiko Matsumura, Motonobu Takenaka, Wataru Kuriyama, Toshiyuki Murayama, Hideki Nara, Tohru Yokozawa, Kenji Yagi
  • Method for producing an optically active tetrahydroquinoline
    Patent number: 7601842
    Abstract: The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a ?-ketoester of formula (2) ?with an amine of formula (3) ?to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active ?-amino acid derivative of formula (5); 3) a step of amidating the optically active ?-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) a step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); ?and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: October 13, 2009
    Assignee: Takasago International Corporation
    Inventors: Takashi Moroi, Tsukasa Sotoguchi, Kazuhiko Matsumura, Motonobu Takenaka, Wataru Kuriyama, Toshiyuki Murayama, Hideki Nara, Tohru Yokozawa, Kenji Yagi
  • Method for producing an optically active tetrahydroquinoline
    Publication number: 20060122225
    Abstract: The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a ?-ketoester of formula (2) ?with an amine of formula (3) ?to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active ?-amino acid derivative of formula (5); 3) a step of amidating the optically active ?-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) a step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); ?and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).
    Type: Application
    Filed: February 17, 2004
    Publication date: June 8, 2006
    Inventors: Takashi Moroi, Tsukasa Sotoguchi, Kazuhiko Matsumura, Motonobu Takenaka, Wataru Kuriyama, Toshiyuki Murayama, Hideki Nara, Tohru Yokozawa, Kenji Yagi
  • Ammonium 3,5,6-trihydroxyhexanoate derivatives and preparation process thereof
    Publication number: 20020052515
    Abstract: Provided are a novel ammonium (3R,5S)-3,5,6-trihydroxyhexanoate derivative represented by the following formula (I): 1
    Type: Application
    Filed: August 16, 2001
    Publication date: May 2, 2002
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kenzo Sumi, Toshiyuki Murayama, Yoshiharu Gonda, Hideki Nara, Takashi Moroi
  • Ammonium 3,5,6-trihydroxyhexanoate derivatives and preparation process thereof
    Patent number: 6365755
    Abstract: Provided are a novel ammonium (3R,5S)-3,5,6-trihydroxyhexanoate derivative represented by the following formula (I): wherein R1 represents a benzyl group which may have a substituent, a triphenylmethyl group which may have a substituent, an organosilyl group or a C1-5 acyl group; and A means a specific amine; and a preparation process of the derivative.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: April 2, 2002
    Assignee: Takasago International Corporation
    Inventors: Kenzo Sumi, Toshiyuki Murayama, Yoshiharu Gonda, Hideki Nara, Takashi Moroi