Abstract: Disclosed herein an anti-pT217 Tau antibody or a pT217 Tau-binding fragment thereof.

Abstract: A laser welding method according to an embodiment includes a preparation process and a welding process. The preparation process includes preparing a temporarily-welded member that includes multiple connection portions by temporarily welding a second member to a first member. The welding process includes welding the second member to the first member by irradiating a laser beam on the temporarily-welded member. In the welding process, a first process is performed, after which a second process is performed. The first process includes irradiating a laser beam from a prescribed position to a second connection portion, wherein the second connection portion is adjacent to a first connection portion, and the prescribed position is between the first connection portion and the second connection portion. The second process includes irradiating a laser beam from the first connection portion to the prescribed position.

Abstract: The present invention provides an anti-APOA4 monoclonal antibody or an antibody fragment thereof capable of accurately measuring apolipoprotein A-IV (APOA4) in a specimen, a measurement method for immunologically measuring APOA4 using the antibody or the antibody fragment thereof, and a kit for measuring APOA4 containing the antibody or the antibody fragment thereof.

Abstract: An inspection device includes an imager and a processor. The imager acquires first image data and second image data. The first image data is of a first weld zone imaged using a first condition. The first weld zone includes a first non-weld area, a second non-weld area, and a first weld area between the first non-weld area and the second non-weld area. The second image data is of the first weld zone imaged using a second condition. The processor performs a first inspection. The first inspection is based on a result of detecting a first boundary and a result of detecting a second boundary. The first boundary is between the first non-weld area and the first weld area based on the first image data. The second boundary is between the first weld area and the second non-weld area based on the second image data.

Abstract: The present invention provides an anti-APOA4 monoclonal antibody or an antibody fragment thereof capable of accurately measuring apolipoprotein A-IV (APOA4) in a specimen, a measurement method for immunologically measuring APOA4 using the antibody or the antibody fragment thereof, and a kit for measuring APOA4 containing the antibody or the antibody fragment thereof.

Abstract: The present invention provides a method for evaluating the pharmacological action of HGF that utilizes a PD marker in which fluctuation is recognized by administration of hepatocyte growth factor (HGF) in a broader range of subjects. A method for evaluating the pharmacodynamic action of HGF is provided. The aforementioned evaluation method is characterized in that it comprises a step of measuring the ApoA4 level in a biological sample collected from a test subject who was administered HGF. According to the present invention, a kit for evaluating the pharmacodynamic action of HGF comprising an anti-ApoA4 antibody is further provided.

Abstract: A battery includes a casing, a terminal, an electrode assembly, a collector, and a joint. The terminal is supported by the casing. The electrode assembly is housed in the casing and includes an electrode pair of a sheet form having different polarities from each other and a separator located between the electrode pair, the electrode pair and the separator laminated and wound around an axis. The collector is located at an axial end of the electrode assembly, electrically connected to the terminal, and includes a plurality of collector tabs. The collector tabs are part of one of the electrodes and laminated on each other with no other electrode and the separator placed in-between. The joint joins fringes of the laminated collector tabs.

Abstract: According to an embodiment, a welding method comprises pretreatment of melting a part of the first member formed by die casting and solidifying the part of the first member. The method may comprise welding the first member and the second member by melting the solidified part of the first member and the second member in contact with each other.

Abstract: A machining apparatus that need not exchange a processing nozzle when changing a shaping condition, and increases the use efficiency of a material. The processing nozzle that performs processing by ejecting a processing material towards a molten pool formed on a process surface by an energy line includes a cylindrical inner housing that incorporates a path through which the energy line passes, and ejects the energy line from one end. The processing nozzle also includes a cylindrical outer housing that incorporates the inner housing, and has an inner surface tapered in the ejection direction of the energy line ejected from the inner housing. The processing nozzle also includes a slide mechanism that changes, along the energy line, the relative position of the outer housing with respect to the inner housing.

Abstract: An optical processing head capable of reducing the energy loss at the time of optical processing is disclosed. The optical processing head includes a first optical element that converts light emitted by a light source into first parallel light, a second optical element that is arranged downstream of the first optical element and converts the first parallel light into first divergent light, a third optical element that is arranged downstream of the second optical element and converts the first divergent light into second parallel light, and a fourth optical element that is arranged downstream of the third optical element and converts the second parallel light into convergent light which is condensed on the processing surface side.

Abstract: An optical processing nozzle that homogeneously supplies a fluid to a processing surface in optical processing. The optical processing nozzle includes a beam path that is arranged so that a beam can pass through the beam path towards a processing surface in order to perform processing using a beam guided from a light source, and a channel structure that is arranged around the beam path and is configured to eject a fluid towards the processing surface. The channel structure includes an inflow port through which the fluid flows, at least two passage holes through which the fluid flowing from the inflow port passes, a channel that guides the fluid from the inflow port to the passage holes, and an ejection port from which the fluid having passed through the at least two passage holes is ejected toward the processing surface.

Abstract: An optical processing head capable of downsizing an apparatus while increasing the shaping accuracy of optical processing is disclosed. The optical processing head performs processing while moving, in a predetermined moving direction on a processing surface, an optical spot formed by condensing light emitted by a light source. The optical processing head includes an optical element that condenses light emitted by the light source to generate the optical spot of a shape elongated in the moving direction of the optical spot. Part of the optical spot is set as a processing region, the front side and/or rear side of the processing region in the moving direction is set as a pre-heating region and/or post-heating region, and a processing target object before and/or after processing in the region is heated.

Abstract: An optical processing head that detects a trouble of an optical processing head that will be generated at the time of optical processing before the trouble occurs is disclosed. The optical processing head that performs processing by condensing, on a process surface, a ray emitted by a light source for processing includes a cylindrical housing that surrounds a ray for processing emitted by the light source for processing, a ray emitter for inspection that is incorporated in the cylindrical housing and arranged outside the path of the ray for processing, and a light receiver that is incorporated in the cylindrical housing, arranged outside the path of the ray for processing, and receives a ray for inspection emitted by the ray emitter for inspection. The contamination of the inner surface of the cylindrical housing or the concentration of a scattering object flowing into the cylindrical housing is inspected by using a signal acquired from the light receiver.

Abstract: Ejection and stop of a powder flow are switched while maintaining a once generated steady flow without stopping it. A processing nozzle includes a supply source of a fluid containing a powder, a first channel through which the fluid supplied from the supply source passes, a second channel that supplies the fluid to an ejection port of the nozzle, a third channel that releases the fluid outside the nozzle, and a switch that causes the first channel and the second channel to communicate with each other when supplying the fluid to the ejection port, and causes the first channel and the third channel to communicate with each other when not supplying the fluid to the ejection port.

Abstract: An overall apparatus is downsized by reducing the size of a light beam branching structure. There is provided an optical processing head including an optical element group that guides a processing light beam from a light source to a process surface, and a light beam branching portion that branches reflected light of the processing light beam from the process surface and an observation light beam for observing a state of the process surface. The light beam branching portion is arranged on a light beam path of the processing light beam, and includes, between the optical element group and the process surface, a half mirror that guides the observation light beam to an observation optical system.

Abstract: This specification discloses an optical processing head including a light guide portion that guides, to a process surface, a ray for processing. The light guide portion is further configured to guide, to the process surface, a ray for inspection different in wavelength from the ray for processing. The optical processing head further includes an inspection portion that inspects the state of the process surface based on reflected light of the ray for inspection reflected by the process surface. With the optical processing head, the state of the process surface can be easily inspected even during optical processing.

Abstract: A method for detecting a neurological disease associated with cognitive impairment, wherein the extracellular domain of EphA4 is measured from a biological sample taken from a subject.

Abstract: Ejection and stop of a powder flow are switched while maintaining a once generated steady flow without stopping it. A processing nozzle includes a supply source of a fluid containing a powder, a first channel through which the fluid supplied from the supply source passes, a second channel that supplies the fluid to an ejection port of the nozzle, a third channel that releases the fluid outside the nozzle, and a switch that causes the first channel and the second channel to communicate with each other when supplying the fluid to the ejection port, and causes the first channel and the third channel to communicate with each other when not supplying the fluid to the ejection port.

Abstract: According to one embodiment, there is provided a mask set including a first mask and a second mask. The first mask includes a first device pattern and a first mark pattern. The first mark pattern is used for an inspection of a position of the first device pattern on a surface of the first mask. The second mask is used to perform multiple exposure on a substrate together with the first mask. The second mask includes a second device pattern and a second mark pattern. The second mark pattern is used for an inspection of a position of the second device pattern on a surface of the second mask. The second mark pattern includes a pattern corresponding to a pattern obtained by inverting the first mark pattern.

Abstract: This specification discloses an optical processing head including a light guide portion that guides, to a process surface, a ray for processing. The light guide portion is further configured to guide, to the process surface, a ray for inspection different in wavelength from the ray for processing. The optical processing head further includes an inspection portion that inspects the state of the process surface based on reflected light of the ray for inspection reflected by the process surface. With the optical processing head, the state of the process surface can be easily inspected even during optical processing.