Patents by Inventor Takashi Oshiyama
Takashi Oshiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140343277Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.Type: ApplicationFiled: June 25, 2014Publication date: November 20, 2014Inventors: Shinichi TAIRA, Kunio OSHIMA, Takashi OSHIYAMA, Yasuhiro MENJO, Yasuo KOGA, Hokuto YAMABE, Sunao NAKAYAMA, Kenji TSUJIMAE, Toshiyuki ONOGAWA, Kuninori TAI, Motohiro ITOTANI
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Patent number: 8822453Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.Type: GrantFiled: August 20, 2010Date of Patent: September 2, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Shuuji Matsumura, Hokuto Yamabe, Naohiro Isono, Noriaki Takemura, Takashi Oshiyama, Tsuyoshi Nagase, Masataka Ueda, Kuninori Tai
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Patent number: 8664217Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; Al is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.Type: GrantFiled: August 22, 2012Date of Patent: March 4, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kunio Oshima, Takashi Oshiyama, Shinichi Taira, Yasuhiro Menjo, Hokuto Yamabe, Shuuji Matsumura, Masataka Ueda, Yasuo Koga, Kuninori Tai, Sunao Nakayama, Toshiyuki Onogawa, Kenji Tsujimae
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Publication number: 20130040941Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.Type: ApplicationFiled: August 22, 2012Publication date: February 14, 2013Inventors: Kunio Oshima, Takashi Oshiyama, Shinichi Taira, Yasuhiro Menjo, Hokuto Yamabe, Shuuji Matsumura, Masataka Ueda, Yasuo Koga, Kuninori Tai, Sunao Nakayama, Toshiyuki Onogawa, Kenji Tsujimae
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Patent number: 8338406Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.Type: GrantFiled: February 20, 2009Date of Patent: December 25, 2012Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kunio Oshima, Takashi Oshiyama, Shinichi Taira, Yasuhiro Menjo, Hokuto Yamabe, Shuuji Matsumura, Masataka Ueda, Yasuo Koga, Kuninori Tai, Sunao Nakayama, Toshiyuki Onogawa, Kenji Tsujimae
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Publication number: 20120225866Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.Type: ApplicationFiled: August 20, 2010Publication date: September 6, 2012Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Kunio Oshima, Shuuji Matsumura, Hokuto Yamabe, Naohiro Isono, Noriaki Takemura, Shinichi Taira, Takashi Oshiyama, Yasuhiro Menjo, Tsuyoshi Nagase, Masataka Ueda, Yasuo Koga, Sunao Nakayama, Kenji Tsujimae, Toshiyuki Onogawa, Kuninori Tai, Motohiro Itotani
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Publication number: 20100331317Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.Type: ApplicationFiled: February 20, 2009Publication date: December 30, 2010Inventors: Kunio Oshima, Takashi Oshiyama, Shinichi Taira, Yasuhiro Menjo, Hokuto Yamabe, Shuuji Matsumura, Masataka Ueda, Yasuo Koga, Kuninori Tai, Sunao Nakayama, Toshiyuki Onogawa, Kenji Tsujimae
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Patent number: 6108709Abstract: A superior data sending apparatus has an alternate forwarding function for the exchange of data by different receiving terminal models. A sender attempts to send a message to one of several receiving terminals carried by a receiver. When communication is not established under a predetermined condition, e.g., within a predetermined period of time, the sender then tries alternate message forwarding to another receiving terminal carried by the same receiver. Since alternate forwarding is automatically performed in accordance with alternate forwarding information registered in advance, no effort is required of a user. Even when the received data processing capability (e.g., the input available character size) differs between the originally designated receiving terminal and the alternate receiving terminal, the system changes the format of the contents of message or the size of the message to one that is adequate, so that an alternate, seamless forwarding can be implemented.Type: GrantFiled: February 19, 1998Date of Patent: August 22, 2000Assignee: International Business Machines Corp.Inventors: Masahiko Shinomura, Takashi Oshiyama
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Patent number: 5937157Abstract: According to the present invention, illegal invasion (i.e., access to secret data) from an installed PC card of an information processing apparatus can be appropriately prevented. When an operating mode enters a security mode, a personal computer performs a pseudo operation as though a device were not installed therein, regardless of whether the device is actually installed. During the security mode, therefore, power is not supplied to the installed device so that it does not become active. During this mode, the information processing apparatus can not exchange data with the installed device.Type: GrantFiled: April 22, 1996Date of Patent: August 10, 1999Assignee: International Business Machines CorporationInventors: Takashi Oshiyama, Masahiko Shinomura
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Patent number: 5926623Abstract: A data transmission method for transmitting data from a first processing unit having a relatively large memory capacity to a second processing unit having a relatively small memory capacity. The method has steps of (a) retrieving data stored in a first memory device, (b) storing in a temporary file only a record, from the retrieved data, relating to a predetermined time period including a current date; (c) determining whether or not the size of the temporary file is within the capacity of a second, smaller capacity, memory device; and (d) transferring the temporary file to the second processing unit in response to an affirmative result of the step (c), or not transferring the temporary file to the second processing unit in response to a negative result of the step (c).Type: GrantFiled: January 2, 1997Date of Patent: July 20, 1999Assignee: International Business Machines CorporationInventors: Nobuyuki Tsukakoshi, Takashi Oshiyama
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Patent number: 5857024Abstract: An IC card 30, which is employed to permit the exchange of secret information while ensuring that security is maintained, includes: a ROM 38 in which an ID is held; a clock 42; a RAM 40 in which a password is stored; a RAM 36 in which a ciphering program is stored; and a CPU 34 that executes a process. The ciphering program is loaded, the stored ID, password and the time t measured by the clock 42 are read and encoded in accordance with the ciphering program, and the results are outputted to a computer system 10. The computer system 10 decodes the output from the IC card 30 and extracts a password, and compares the decoded password with a registered password. When the passwords match, access is enabled; but when they do not match, access is disabled.Type: GrantFiled: October 2, 1996Date of Patent: January 5, 1999Assignee: International Business Machines CorporationInventors: Kiyoshi Nishino, Takashi Oshiyama
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Patent number: 5822597Abstract: A information processing system which enters power management mode when a predetermined time has elapsed since a last user input (or a last processing operation), adjusts the predetermined time according to the action of the operator in response to entering the power mode. If the user transfers back to normal mode quickly the predetermined reference time is increased. If the user responds only after a delay period the predetermined reference time is decreased. By so adjusting the predetermined time a better balance is achieved between energy saving and user convenience for a current level of operator attention to the computer.Type: GrantFiled: May 23, 1996Date of Patent: October 13, 1998Assignee: International Business Machines Corp.Inventors: Seiichi Kawano, Kohsuke Ohtani, Tomoki Maruichi, Yasunori Maezawa, Takashi Oshiyama