Patents by Inventor Takashi Oshiyama

Takashi Oshiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140343277
    Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.
    Type: Application
    Filed: June 25, 2014
    Publication date: November 20, 2014
    Inventors: Shinichi TAIRA, Kunio OSHIMA, Takashi OSHIYAMA, Yasuhiro MENJO, Yasuo KOGA, Hokuto YAMABE, Sunao NAKAYAMA, Kenji TSUJIMAE, Toshiyuki ONOGAWA, Kuninori TAI, Motohiro ITOTANI
  • Patent number: 8822453
    Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: September 2, 2014
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Shuuji Matsumura, Hokuto Yamabe, Naohiro Isono, Noriaki Takemura, Takashi Oshiyama, Tsuyoshi Nagase, Masataka Ueda, Kuninori Tai
  • Patent number: 8664217
    Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; Al is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: March 4, 2014
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Kunio Oshima, Takashi Oshiyama, Shinichi Taira, Yasuhiro Menjo, Hokuto Yamabe, Shuuji Matsumura, Masataka Ueda, Yasuo Koga, Kuninori Tai, Sunao Nakayama, Toshiyuki Onogawa, Kenji Tsujimae
  • Publication number: 20130040941
    Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.
    Type: Application
    Filed: August 22, 2012
    Publication date: February 14, 2013
    Inventors: Kunio Oshima, Takashi Oshiyama, Shinichi Taira, Yasuhiro Menjo, Hokuto Yamabe, Shuuji Matsumura, Masataka Ueda, Yasuo Koga, Kuninori Tai, Sunao Nakayama, Toshiyuki Onogawa, Kenji Tsujimae
  • Patent number: 8338406
    Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: December 25, 2012
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Kunio Oshima, Takashi Oshiyama, Shinichi Taira, Yasuhiro Menjo, Hokuto Yamabe, Shuuji Matsumura, Masataka Ueda, Yasuo Koga, Kuninori Tai, Sunao Nakayama, Toshiyuki Onogawa, Kenji Tsujimae
  • Publication number: 20120225866
    Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.
    Type: Application
    Filed: August 20, 2010
    Publication date: September 6, 2012
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Kunio Oshima, Shuuji Matsumura, Hokuto Yamabe, Naohiro Isono, Noriaki Takemura, Shinichi Taira, Takashi Oshiyama, Yasuhiro Menjo, Tsuyoshi Nagase, Masataka Ueda, Yasuo Koga, Sunao Nakayama, Kenji Tsujimae, Toshiyuki Onogawa, Kuninori Tai, Motohiro Itotani
  • Publication number: 20100331317
    Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.
    Type: Application
    Filed: February 20, 2009
    Publication date: December 30, 2010
    Inventors: Kunio Oshima, Takashi Oshiyama, Shinichi Taira, Yasuhiro Menjo, Hokuto Yamabe, Shuuji Matsumura, Masataka Ueda, Yasuo Koga, Kuninori Tai, Sunao Nakayama, Toshiyuki Onogawa, Kenji Tsujimae
  • Patent number: 6108709
    Abstract: A superior data sending apparatus has an alternate forwarding function for the exchange of data by different receiving terminal models. A sender attempts to send a message to one of several receiving terminals carried by a receiver. When communication is not established under a predetermined condition, e.g., within a predetermined period of time, the sender then tries alternate message forwarding to another receiving terminal carried by the same receiver. Since alternate forwarding is automatically performed in accordance with alternate forwarding information registered in advance, no effort is required of a user. Even when the received data processing capability (e.g., the input available character size) differs between the originally designated receiving terminal and the alternate receiving terminal, the system changes the format of the contents of message or the size of the message to one that is adequate, so that an alternate, seamless forwarding can be implemented.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: August 22, 2000
    Assignee: International Business Machines Corp.
    Inventors: Masahiko Shinomura, Takashi Oshiyama
  • Patent number: 5937157
    Abstract: According to the present invention, illegal invasion (i.e., access to secret data) from an installed PC card of an information processing apparatus can be appropriately prevented. When an operating mode enters a security mode, a personal computer performs a pseudo operation as though a device were not installed therein, regardless of whether the device is actually installed. During the security mode, therefore, power is not supplied to the installed device so that it does not become active. During this mode, the information processing apparatus can not exchange data with the installed device.
    Type: Grant
    Filed: April 22, 1996
    Date of Patent: August 10, 1999
    Assignee: International Business Machines Corporation
    Inventors: Takashi Oshiyama, Masahiko Shinomura
  • Patent number: 5926623
    Abstract: A data transmission method for transmitting data from a first processing unit having a relatively large memory capacity to a second processing unit having a relatively small memory capacity. The method has steps of (a) retrieving data stored in a first memory device, (b) storing in a temporary file only a record, from the retrieved data, relating to a predetermined time period including a current date; (c) determining whether or not the size of the temporary file is within the capacity of a second, smaller capacity, memory device; and (d) transferring the temporary file to the second processing unit in response to an affirmative result of the step (c), or not transferring the temporary file to the second processing unit in response to a negative result of the step (c).
    Type: Grant
    Filed: January 2, 1997
    Date of Patent: July 20, 1999
    Assignee: International Business Machines Corporation
    Inventors: Nobuyuki Tsukakoshi, Takashi Oshiyama
  • Patent number: 5857024
    Abstract: An IC card 30, which is employed to permit the exchange of secret information while ensuring that security is maintained, includes: a ROM 38 in which an ID is held; a clock 42; a RAM 40 in which a password is stored; a RAM 36 in which a ciphering program is stored; and a CPU 34 that executes a process. The ciphering program is loaded, the stored ID, password and the time t measured by the clock 42 are read and encoded in accordance with the ciphering program, and the results are outputted to a computer system 10. The computer system 10 decodes the output from the IC card 30 and extracts a password, and compares the decoded password with a registered password. When the passwords match, access is enabled; but when they do not match, access is disabled.
    Type: Grant
    Filed: October 2, 1996
    Date of Patent: January 5, 1999
    Assignee: International Business Machines Corporation
    Inventors: Kiyoshi Nishino, Takashi Oshiyama
  • Patent number: 5822597
    Abstract: A information processing system which enters power management mode when a predetermined time has elapsed since a last user input (or a last processing operation), adjusts the predetermined time according to the action of the operator in response to entering the power mode. If the user transfers back to normal mode quickly the predetermined reference time is increased. If the user responds only after a delay period the predetermined reference time is decreased. By so adjusting the predetermined time a better balance is achieved between energy saving and user convenience for a current level of operator attention to the computer.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: October 13, 1998
    Assignee: International Business Machines Corp.
    Inventors: Seiichi Kawano, Kohsuke Ohtani, Tomoki Maruichi, Yasunori Maezawa, Takashi Oshiyama