Patents by Inventor Takashi Temma

Takashi Temma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Switching-type fluorescent nanoparticle probe, and fluorescent molecular imaging method using same
    Patent number: 9849197
    Abstract: [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged).
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: December 26, 2017
    Assignees: KYOTO UNIVERSITY, SHIMADZU CORPORATION
    Inventors: Hideo Saji, Shunsaku Kimura, Masahiro Ono, Takashi Temma, Isao Hara, Eiichi Ozeki
  • Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same
    Patent number: 9370589
    Abstract: The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: June 21, 2016
    Assignees: SHIMADZU CORPORATION, KYOTO UNIVERSITY
    Inventors: Isao Hara, Eiichi Ozeki, Hideo Saji, Shunsaku Kimura, Masahiro Ono, Takashi Temma
  • SWITCHING-TYPE FLUORESCENT NANOPARTICLE PROBE, AND FLUORESCENT MOLECULAR IMAGING METHOD USING SAME
    Publication number: 20130336896
    Abstract: [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged).
    Type: Application
    Filed: March 1, 2012
    Publication date: December 19, 2013
    Inventors: Hideo Saji, Shunsaku Kimura, Masahiro Ono, Takashi Temma, Isao Hara, Eiichi Ozeki
  • SWITCHING FLUORESCENT NANOPARTICLE PROBE AND FLUORESCENT PARTICLE IMAGING METHOD USING SAME
    Publication number: 20130149252
    Abstract: The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.
    Type: Application
    Filed: August 8, 2011
    Publication date: June 13, 2013
    Inventors: Isao Hara, Eiichi Ozeki, Hideo Saji, Shunsaku Kimura, Masahiro Ono, Takashi Temma