Patents by Inventor Takashi Tomimatsu

Takashi Tomimatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION CONTAINING TETRACYCLIC COMPOUND AT HIGH DOSE
    Publication number: 20230105990
    Abstract: An improved solubility of a pharmaceutical composition or formulation containing a large amount of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile or a salt thereof can be achieved by forming granules of the compound or salt thereof and allowing the granules to be present together with a disintegrating agent.
    Type: Application
    Filed: August 26, 2022
    Publication date: April 6, 2023
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi TOMIMATSU, Kensuke OKAZAKI, Yumi OGAWA, Takahiro YAMAMURA
  • PREPARATION CONTAINING TETRACYCLIC COMPOUND AT HIGH DOSE
    Publication number: 20220378800
    Abstract: An improved solubility of a pharmaceutical composition or formulation containing a large amount of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile or a salt thereof can be achieved by forming granules of the compound or salt thereof and allowing the granules to be present together with a disintegrating agent.
    Type: Application
    Filed: July 29, 2022
    Publication date: December 1, 2022
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi TOMIMATSU, Kensuke OKAZAKI, Yumi OGAWA, Takahiro YAMAMURA
  • Preparation containing tetracyclic compound at high dose
    Patent number: 11433076
    Abstract: An improved solubility of a pharmaceutical composition or formulation containing a large amount of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile or a salt thereof can be achieved by forming granules of the compound or salt thereof and allowing the granules to be present together with a disintegrating agent.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: September 6, 2022
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi Tomimatsu, Kensuke Okazaki, Yumi Ogawa, Takahiro Yamamura
  • PREPARATION CONTAINING TETRACYCLIC COMPOUND AT HIGH DOSE
    Publication number: 20200038407
    Abstract: An improved solubility of a pharmaceutical composition or formulation containing a large amount of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile or a salt thereof can be achieved by forming granules of the compound or salt thereof and allowing the granules to be present together with a disintegrating agent.
    Type: Application
    Filed: July 11, 2019
    Publication date: February 6, 2020
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi TOMIMATSU, Kensuke OKAZAKI, Yumi OGAWA, Takahiro YAMAMURA
  • Preparation containing tetracyclic compound at high dose
    Patent number: 10350214
    Abstract: An improved solubility of a pharmaceutical composition or formulation containing a large amount of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile or a salt thereof can be achieved by forming granules of the compound or salt thereof and allowing the granules to be present together with a disintegrating agent.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: July 16, 2019
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Takashi Tomimatsu, Kensuke Okazaki, Yumi Ogawa, Takahiro Yamamura
  • PREPARATION CONTAINING TETRACYCLIC COMPOUND AT HIGH DOSE
    Publication number: 20170035773
    Abstract: An improved solubility of a pharmaceutical composition or formulation containing a large amount of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile or a salt thereof can be achieved by forming granules of the compound or salt thereof and allowing the granules to be present together with a disintegrating agent.
    Type: Application
    Filed: April 24, 2015
    Publication date: February 9, 2017
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi Tomimatsu, Kensuke OKAZAKI, Yumi OGAWA, Takahiro YAMAMURA
  • Cell Death Inducing Agents
    Publication number: 20070280951
    Abstract: The present inventors constructed a DNA expression vector encoding 2D7sc(Fv)2 in which the heavy chain variable region sequence (VH) and the light chain variable region sequence (VL) of the 2D7 antibody is arranged in the order of VH-VL-VH-VL, and these sequences are linked by a 15-mer linker. The vector was introduced into CHO cells and a 2D7sc(Fv)2-producing expression cell line was established. When 2D7sc(Fv)2 was expressed in this cell line, purified, and cell death-inducing experiments performed, 2D7sc(Fv)2 was found to have a concentration-dependent cell death-inducing activity.
    Type: Application
    Filed: December 10, 2004
    Publication date: December 6, 2007
    Inventors: Naoki Kimura, Masayuki Tsuchiya, Masahiko Nanami, Takashi Tomimatsu, Shigeto Kawai