Abstract: The charging inlet includes a front housing; a terminal stored in the front housing; a thermistor stored in the front housing and detecting the temperature of the terminal; and a terminal holder attached to the front housing and holding the terminal. The terminal holder has a protrusion for regulating slip-off of the thermistor stored in the front housing.

Abstract: An unsaturated polyester resin composition includes an unsaturated polyester, a polymerizable monomer, a low shrinkage agent, aluminum hydroxide, and an electrically conductive filler. The unsaturated polyester is a polymerization product of a polybasic acid including a polybasic acid having an ethylenically unsaturated double bond at a predetermined ratio and a polyhydric alcohol. A polyvinyl acetate as the low shrinkage agent is included at a predetermined ratio with respect to the total amount of the unsaturated polyester, the polymerizable monomer, and the low shrinkage agent. The aluminum hydroxide is included at a predetermined ratio with respect to the total amount of the unsaturated polyester, the polymerizable monomer, and the low shrinkage agent.

Abstract: Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer or HIV-1, are provided.

Abstract: Caffeic Acid, L-DOPA, and D-DOPA and prodrugs thereof for treating a disease, condition, or disorder associated with excess glutamate carboxypeptidase II (GCP-II) are disclosed.

Abstract: Compositions of dendrimers conjugated with one or more glutamine antagonist(s) that inhibit glutamine metabolism, preferably in activated microglia, and methods of use thereof for treating, alleviating, and/or preventing one or more neurological, oncological, and/or immune disorders associated with pathogenic or dysregulated glutamine-dependent pathways and/or glutamate transmission, have been developed. Dendrimers conjugated with one or more glutamine antagonists effectively inhibit the activity of glutaminase without any systemic toxicity. Dendrimers conjugated with one or more glutamine antagonists accumulate in activated microglia associated with the injured or diseased cells and tissues.

Abstract: A substrate processing apparatus, includes: a process chamber accommodating a substrate; a vaporizer vaporizing a liquid precursor to generate reaction gas and deliver a processing gas containing the reaction gas and a carrier gas, the vaporizer including: a vaporization vessel; and a heater heating the liquid precursor introduced into the vessel; a carrier gas flow rate controller controlling flow rate of the carrier gas supplied to the vaporizer; a liquid precursor flow rate controller controlling flow rate of the liquid precursor; a processing gas supply pipe introducing the processing gas delivered from the vaporizer into the process chamber; and a gas concentration sensor detecting a gas concentration of the reaction gas contained in the processing gas delivered from the vaporizer into the processing gas supply pipe.

Abstract: An amount of information of data of a captured image displayed on a display unit is increased. A display control unit sets a plurality of divided display sections for a display unit. The display control unit sets a first camera group and a second camera group including one or more of a plurality of cameras. The first camera group captures an image of a work performed with a blade. The second camera group captures an image of a work performed with a ripper. The display control unit displays data of captured images output from cameras included in one of the first and second camera groups in a corresponding plurality of divided display sections.

Abstract: An unsaturated polyester resin composition contains an unsaturated polyester, a vinyl ester, a polymerizable monomer, and an aluminum hydroxide. The vinyl ester is a reaction product of an epoxy resin and an unsaturated monobasic acid. The vinyl ester is blended in a predetermined ratio to the unsaturated polyester. The aluminum hydroxide is blended in a predetermined ratio to the vinyl ester.

Abstract: Positive allosteric modulators (PAMs) of Mas-related G protein-coupled receptor X1 (MRGPRX1) and their use for treating neuropathic pain is disclosed.

Abstract: A connector includes a housing having a first connection portion and a second connection portion adjacent to the first connection portion, a first cap and a second cap pivotally supported by the housing respectively to be displaceable between an open position where the first and second connection portions are exposed to outside and a closed position where the first and second connection portions are shielded from the outside, a first lock and a second lock rotatably supported by the housing to lock the first cap and the second cap respectively, and a power transmission member rotatably supported by the housing. The power transmission member is configured to transmit a rotational force in a lock releasing direction of the second lock to the first lock such that the first cap and the second cap are integrally displaced to the open position.

Abstract: A connector includes a housing having a first connection portion and a second connection portion adjacent to the first connection portion, a first cap and a second cap pivotally supported by the housing respectively to be displaceable between an open position where the first and second connection portions are exposed to outside and a closed position where the first and second connection portions are shielded from the outside, a first lock and a second lock rotatably supported by the housing configured to lock the first cap and the second cap respectively. The second lock has a power transmission portion configured to transmit a rotational force in a lock releasing direction of the second lock to the first lock such that the first cap and the second cap are integrally displaced to the open position.

Abstract: A thin plate molding material includes a resin composition containing a resin component and a filling material, and a reinforced fiber with a predetermined fiber length. The content ratio of the reinforced fiber is a predetermined ratio. The mixing ratio of the resin component is a predetermined ratio.

Abstract: Currently available glutaminase inhibitors are generally poorly soluble, metabolically unstable, and/or require high doses, which together reduce their efficacy and therapeutic index. These can be formulated into nanoparticles and delivered safely and effectively for treatment of pancreatic cancer and other glutamine addicted cancers. Studies demonstrate that nanoparticle delivery of BPTES, relative to use of BPTES alone, can be safely administered and provides dramatically improved tumor drug exposure, resulting in greater efficacy. GLS inhibitors can be administered in higher concentrations with sub-100 nm nanoparticles, since the nanoparticles package the drug into “soluble” colloidal nanoparticles, and the nanoparticles deliver higher drug exposure selectively to the tumors due to the enhanced permeability and retention (EPR) effect. These factors result in sustained drug levels above the IC50 within the tumors for days, providing significantly enhanced efficacy compared to unencapsulated drug.

Abstract: Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer or HIV-1, are provided.

Abstract: An unsaturated polyester resin composition includes an unsaturated polyester, a polymerizable monomer, a low shrinkage agent, aluminum hydroxide, and an electrically conductive filler. The unsaturated polyester is a polymerization product of a polybasic acid including a polybasic acid having an ethylenically unsaturated double bond at a predetermined ratio and a polyhydric alcohol. A polyvinyl acetate as the low shrinkage agent is included at a predetermined ratio with respect to the total amount of the unsaturated polyester, the polymerizable monomer, and the low shrinkage agent. The aluminum hydroxide is included at a predetermined ratio with respect to the total amount of the unsaturated polyester, the polymerizable monomer, and the low shrinkage agent.

Abstract: Provided is a display system, which makes it easy for an operator to accurately grasp a traveling situation of a work vehicle. A front camera captures an excavating blade and topography in front of a crawler dozer. A rear camera captures a fuel tank and a ripper apparatus, and a topography behind the crawler dozer. A display image displayed on a monitor is generated by arranging a front image captured by the front camera and a rear image captured by the rear camera so that the excavating blade in the front image may face the fuel tank in the rear image.

Abstract: An unsaturated polyester resin composition includes: a resin component comprising an unsaturated polyester, a polymerizable monomer, and a low profile agent; aluminum hydroxide; and a fire retardant. The unsaturated polyester is a polymerized product of polybasic acid and polyhydric alcohol. The polybasic acid has an ethylenic unsaturated double bond at a predetermined ratio. The polyvinyl acetate is blended as a low profile agent relative to the resin component at a predetermined ratio. Aluminum hydroxide is blended relative to the resin component at a predetermined ratio.

Abstract: Currently available glutaminase inhibitors are generally poorly soluble, metabolically unstable, and/or require high doses, which together reduce their efficacy and therapeutic index. These can be formulated into nanoparticles and delivered safely and effectively for treatment of pancreatic cancer and other glutamine addicted cancers. Studies demonstrate that nanoparticle delivery of BPTES, relative to use of BPTES alone, can be safely administered and provides dramatically improved tumor drug exposure, resulting in greater efficacy. GLS inhibitors can be administered in higher concentrations with sub-100 nm nanoparticles, since the nanoparticles package the drug into “soluble” colloidal nanoparticles, and the nanoparticles deliver higher drug exposure selectively to the tumors due to the enhanced permeability and retention (EPR) effect. These factors result in sustained drug levels above the IC50 within the tumors for days, providing significantly enhanced efficacy compared to unencapsulated drug.

Abstract: An amount of information of data of a captured image displayed on a display unit is increased. A display control unit sets a plurality of divided display sections for a display unit. The display control unit sets a first camera group and a second camera group including one or more of a plurality of cameras. The first camera group captures an image of a work performed with a blade. The second camera group captures an image of a work performed with a ripper. The display control unit displays data of captured images output from cameras included in one of the first and second camera groups in a corresponding plurality of divided display sections.

Abstract: A cab is used in a work machine. The cab includes a first pillar, a second pillar disposed to a rear of the first pillar, a beam disposed between the first pillar and the second pillar, and a reinforcing member provided to the beam.