Abstract: A novel compound having an excellent NF?B inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom; R2 represents a hydroxyl group, or a lower alkyloxy group; R3 represents a hydrogen atom, a lower alkyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7 a

Abstract: A bicycle wheel rim structure is provided with a rim, a cap and a tape. The rim includes a first annular side portion, a second annular side portion and an annular bridge portion extending between the first and second annular side portions. The bridge portion has at least one opening. The cap includes a base plate and a projection. The base plate overlies an outer rim surface of the annular bridge portion. The projection extends from the base plate into the at least one opening. The tape is attached to the outer rim surface of the annular bridge portion and overlying the base plate of the cap. The tape is dimensioned to cover an interface between a peripheral edge of the base plate of the cap and the outer rim surface of the annular bridge portion.

Abstract: Provided is a highly safe and effective compound represented by the following general formula (1) or a salt thereof which acts on tubulin and has an anticancer effect, wherein Ar represents an aryl group or a heteroaryl group; Z1, Z2, Z3, and Z4 each independently represent CH, a nitrogen atom, an oxygen atom, or a sulfur atom; R1 represents a hydrogen atom, a halogen atom, an alkyl group, or the like; R2 and R3 are the same or different and each represent a hydrogen atom, a halogen atom, a carboxyl group, or the like; n units of R4 are the same or different and each represent a hydrogen atom, an alkyl group, or the like; and n represents a number of 0 to 4.

Abstract: A novel compound having an excellent NF?B inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like; R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like; R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.

Abstract: Disclosed is a process for production of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin from a camptothecin composition containing 18,19-dehydrocamptothecin without producing any vinyl form of the compound. The process is characterized by catalytically reducing at least one compound selected from a compound (1) and others in the process of producing a compound (5) from a composition containing the compound (1).

Abstract: A bicycle wheel rim structure is provided with a rim, a cap and a tape. The rim includes a first annular side portion, a second annular side portion and an annular bridge portion extending between the first and second annular side portions. The bridge portion has at least one opening. The cap includes a base plate and a projection. The base plate overlies an outer rim surface of the annular bridge portion. The projection extends from the base plate into the at least one opening. The tape is attached to the outer rim surface of the annular bridge portion and overlying the base plate of the cap. The tape is dimensioned to cover an interface between a peripheral edge of the base plate of the cap and the outer rim surface of the annular bridge portion.

Abstract: Disclosed is a process for production of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin from a camptothecin composition containing 18,19-dehydrocamptothecin without producing any vinyl form of the compound. The process is characterized by catalytically reducing at least one compound selected from a compound (1) and others in the process of producing a compound (5) from a composition containing the compound (1).

Abstract: A novel compound having an excellent NF?B inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like; R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like; R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.

Abstract: A novel compound having an excellent NF?B inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom; R2 represents a hydroxyl group, or a lower alkyloxy group; R3 represents a hydrogen atom, a lower alkyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7

Abstract: The present invention relates to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The invention provides an acrylonitrile derivative represented by formula (1): (wherein A represents an optionally substituted 3- to 8-membered heterocyclic ring) or a salt thereof.

Abstract: A bicycle rim is basically provided with an annular metallic rim member and a reinforcing member. The annular metallic rim member includes a plurality of spoke attachment areas with at least one spoke attachment opening in each of the spoke attachment areas. The reinforcing member overlies an exterior surface of the annular metallic rim member. The reinforcing member includes a plurality of spoke attachment sections individually arranged in a circumferential direction to overlie the spoke attachment openings. The spoke attachment sections include a plurality of discrete first reinforcing parts and a plurality of discrete second reinforcing parts. The first reinforcing parts are attached to the spoke attachment areas around the spoke attachment openings. The second reinforcing parts are attached to the spoke attachment areas to overlie the first reinforcing parts, with the second reinforcing parts being larger than the first reinforcing parts.

Abstract: A method for preparing a novel crystalline polymorphic irinotecan hydrochloride which is excellent in the solubility in water and reduced in the content of impurities is provided. A method for preparing c-type crystals of irinotecan hydrochloride having diffraction peaks (2?) at 9.15°, 10.00°, 11.80°, 12.20°, 13.00° and 13.40° in the powder X-ray diffractometry characterized by mixing irinotecan with one or more solvents selected from the group consisting of acetone, acetonitrile and tetrahydrofuran, adding hydrochloric acid, and collecting the formed crystals.

Abstract: A bicycle rim is provided with an annular metallic rim member and at least one reinforcing resin material. The annular metallic rim member includes an annular tire attachment portion adapted to have a tire mounted thereon, a first annular side wall portion, a second annular side wall portion and an inner annular wall portion connecting the first and second annular side wall portions with a plurality of spoke attachment openings formed in the inner annular wall portion. The at least one reinforcing resin material is attached to the annular metallic rim member such that the reinforcing resin material continuously extends from the first annular side wall portion across the inner annular wall portion to the second annular side wall portions to overlie exterior surface areas of the first and second annular side wall portions and exterior surface areas of the inner annular wall portion around the spoke attachment openings.

Abstract: A bicycle rim is provided with an annular metallic rim member and a reinforcing member. The annular metallic rim member has a plurality of spoke attachment arcas with at least one spoke attachment opening in each of the spoke attachment areas and a plurality of intermediate areas disposed between adjacent pairs of the spoke attachment areas. The reinforcing member extends circumferentially about the annular metallic rim member to overlie the spoke attachment areas of the annular metallic rim member. The reinforcing member has a plurality of discrete spoke attachment area reinforcing parts overlying a corresponding one of the spoke attachment areas of the annular metallic rim member. The reinforcing member also has a rim reinforcing part overlying the intermediate areas of the annular metallic rim member and at least partially overlying the discrete spoke attachment area reinforcing parts.

Abstract: A bicycle rim is basically provided with an annular metallic rim member and a reinforcing member. The annular metallic rim member includes a plurality of spoke attachment areas with at least one spoke attachment opening in each of the spoke attachment areas. The reinforcing member overlies an exterior surface of the annular metallic rim member. The reinforcing member includes a plurality of spoke attachment sections individually arranged in a circumferential direction to overlie the spoke attachment openings. The spoke attachment sections include a plurality of discrete first reinforcing parts and a plurality of discrete second reinforcing parts. The first reinforcing parts are attached to the spoke attachment areas around the spoke attachment openings. The second reinforcing parts are attached to the spoke attachment areas to overlie the first reinforcing parts, with the second reinforcing parts being larger than the first reinforcing parts.

Abstract: A bicycle rim is provided with an annular metallic rim member and reinforcing member. The annular metallic rim member has a plurality of spoke attachment areas with a spoke attachment opening in each of the spoke attachment areas. The reinforcing member extends circumferentially about the annular metallic rim member to overlie the spoke attachment areas of the annular metallic rim member. The reinforcing member has a plurality of spoke attachment sections overlying the spoke attachment areas, respectively, and a plurality of intermediate sections disposed between adjacent pairs of the spoke attachment sections, with the spoke attachment sections being thicker than the intermediate sections.

Abstract: A bicycle rim is provided with an annular metallic rim member and at least one reinforcing resin material. The annular metallic rim member includes an annular tire attachment portion adapted to have a tire mounted thereon, a first annular side wall portion, a second annular side wall portion and an inner annular wall portion connecting the first and second annular side wall portions with a plurality of spoke attachment openings formed in the inner annular wall portion. The at least one reinforcing resin material is attached to the annular metallic rim member such that the reinforcing resin material continuously extends from the first annular side wall portion across the inner annular wall portion to the second annular side wall portions to overlie exterior surface areas of the first and second annular side wall portions and exterior surface areas of the inner annular wall portion around the spoke attachment openings.

Abstract: A method for preparing a novel crystalline polymorphic irinotecan hydrochloride which is excellent in the solubility in water and reduced in the content of impurities is provided. A method for preparing c-type crystals of irinotecan hydrochloride having diffraction peaks (2?) at 9.15°, 10.00°, 11.80°, 12.20°, 13.00° and 13.40° in the powder X-ray diffractometry characterized by mixing irinotecan with one or more solvents selected from the group consisting of acetone, acetonitrile and tetrahydrofuran, adding hydrochloric acid, and collecting the formed crystals.

Abstract: Problem: A large scale production of camptothecin, which is a starting compound of irinotecan hydrochloride and various camptothecin derivatives, at a low cost and with ease. Solution: A process for preparing camptothecin, characterized in that it comprises the following steps (a) and (b); (a) the step to hydrolyze 9-methoxycamptothecin or a natural material containing 9-methoxycamptothecin; (b) the step to convert 9-hydroxycamptothecin obtained in the step (a) into camptothecin by 9-O—perfluoro-lower-alkylsulfonylation or 9-O—phenyltetrazolylation, followed by hydrogenolysis.

Abstract: Problem: A large scale production of camptothecin, which is a starting compound of irinotecan hydrochloride and various camptothecin derivatives, at a low cost and with ease.