Patents by Inventor Takashi Yasukochi
Takashi Yasukochi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11813364Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.Type: GrantFiled: August 17, 2021Date of Patent: November 14, 2023Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi Sonobe, Takashi Yasukochi, Yasunori Takada
-
Publication number: 20220062236Abstract: A method for suppressing a plasma concentration of an asenapine metabolite includes applying to a subject a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer includes asenapine and/or a pharmaceutically acceptable salt thereof, and an adhesive base agent.Type: ApplicationFiled: November 10, 2021Publication date: March 3, 2022Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki SUZUKI, Hiroaki OKUTSU, Takashi YASUKOCHI, Yasunori TAKADA
-
Publication number: 20210369638Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.Type: ApplicationFiled: August 17, 2021Publication date: December 2, 2021Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi SONOBE, Takashi YASUKOCHI, Yasunori TAKADA
-
Patent number: 11123305Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.Type: GrantFiled: June 14, 2018Date of Patent: September 21, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi Sonobe, Takashi Yasukochi, Yasunori Takada
-
Patent number: 10814002Abstract: A method for producing a patch including a support layer, and an adhesive agent layer formed on the support layer and including sodium diacetate, a pressure-sensitive adhesive base agent, and asenapine and/or a pharmaceutically acceptable salt thereof. The sodium diacetate is generated from sodium acetate in the presence of the asenapine and/or salt thereof, a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is in range of 3.0 to 20 mg, and when a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is 6.4 mg and the patch is in contact with skin for 24 hours, Cmax of free asenapine is in range of 0.5 to 6.0 ng/mL and tmax of free asenapine is in range of 8 to 28 hr.Type: GrantFiled: December 4, 2018Date of Patent: October 27, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
-
Patent number: 10806705Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.Type: GrantFiled: July 21, 2016Date of Patent: October 20, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takashi Yasukochi, Atsushi Sonobe, Satoshi Amano
-
Patent number: 10583121Abstract: A patch for administering asenapine includes a support layer, and an adhesive agent layer formed on the support layer and including an adhesive base agent and asenapine and/or a pharmaceutically acceptable salt thereof. The adhesive base agent has a content in a range of 10 to 90% by mass in the adhesive agent layer and includes a natural rubber, polyisobutylene, an alkyl vinyl ether(co)polymer, polyisoprene, polybutadiene, a styrene-butadiene copolymer, a styrene-isoprene copolymer, a styrene-isoprene-styrene block copolymer, or a combination thereof. When a content of the asenapine and/or pharmaceutically acceptable salt thereof in terms of free asenapine in the adhesive agent layer is 3.4 mg, an AUC2-120 for a period starting from the time when the patch is brought into contact with a skin for 24 hours is 27,000 pg·hr/mL or more, and an AUC2-120 of an asenapine metabolite is 20% or less of the AUC2-120 of the free asenapine.Type: GrantFiled: March 9, 2017Date of Patent: March 10, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
-
Patent number: 10493156Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 ?m, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 ?m or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.Type: GrantFiled: August 7, 2018Date of Patent: December 3, 2019Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
-
Publication number: 20190343800Abstract: A method for suppressing a plasma concentration of an asenapine metabolite includes applying to a subject a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer includes asenapine and/or a pharmaceutically acceptable salt thereof, and an adhesive base agent.Type: ApplicationFiled: July 24, 2019Publication date: November 14, 2019Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki SUZUKI, Hiroaki OKUTSU, Takashi YASUKOCHI, Yasunori TAKADA
-
Patent number: 10369116Abstract: A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25° C.Type: GrantFiled: February 22, 2016Date of Patent: August 6, 2019Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Yoko Fujiwara, Takashi Yasukochi, Yuka Takagi
-
Publication number: 20190105391Abstract: A method for producing a patch including a support layer, and an adhesive agent layer formed on the support layer and including sodium diacetate, a pressure-sensitive adhesive base agent, and asenapine and/or a pharmaceutically acceptable salt thereof. The sodium diacetate is generated from sodium acetate in the presence of the asenapine and/or salt thereof, a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is in range of 3.0 to 20 mg, and when a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is 6.4 mg and the patch is in contact with skin for 24 hours, Cmax of free asenapine is in range of 0.5 to 6.0 ng/mL and tmax of free asenapine is in range of 8 to 28 hr.Type: ApplicationFiled: December 4, 2018Publication date: April 11, 2019Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
-
Publication number: 20190000775Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.Type: ApplicationFiled: July 21, 2017Publication date: January 3, 2019Inventors: Takashi YASUKOCHI, Atsushi SONOBE, Satoshi AMANO
-
Publication number: 20180360968Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, isopropyl palmitate, and an adhesive base agent.Type: ApplicationFiled: August 7, 2018Publication date: December 20, 2018Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki SUZUKI, Hiroaki OKUTSU, Takashi YASUKOCHI, Yasunori TAKADA
-
Publication number: 20180339050Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 ?m, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 ?m or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.Type: ApplicationFiled: August 7, 2018Publication date: November 29, 2018Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki SUZUKI, Hiroaki OKUTSU, Takashi YASUKOCHI, Yasunori TAKADA
-
Publication number: 20180289631Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.Type: ApplicationFiled: June 14, 2018Publication date: October 11, 2018Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi Sonobe, Takashi Yasukochi, Yasunori Takada
-
Patent number: 10080738Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 ?m, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 ?m or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.Type: GrantFiled: October 24, 2016Date of Patent: September 25, 2018Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
-
Publication number: 20180207108Abstract: The present invention provides a method for manufacturing a patch comprising a backing and an adhesive layer laminated on the backing, comprising: a step of mixing an acid addition salt of asenapine, a (meth)acrylic acid ester (co)polymer and a desalting agent to obtain an adhesive composition; and a step of shaping the adhesive composition to obtain the adhesive layer.Type: ApplicationFiled: July 21, 2016Publication date: July 26, 2018Inventors: Atsushi SONOBE, Takashi YASUKOCHI
-
Patent number: 10022445Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.Type: GrantFiled: July 25, 2013Date of Patent: July 17, 2018Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi Sonobe, Takashi Yasukochi, Yasunori Takada
-
Patent number: 9969688Abstract: The present invention provides a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein R is a hydrogen atom, a C1-6 alkyl group optionally substituted with one or more hydroxyl groups, a C1-6 alkoxy group, or a cyano group.Type: GrantFiled: October 21, 2015Date of Patent: May 15, 2018Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi Sonobe, Takashi Yasukochi, Yasunori Takada, Kenji Atarashi, Motohiro Suzuki, Shinichi Yokota
-
Publication number: 20180085323Abstract: A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25° C.Type: ApplicationFiled: February 22, 2016Publication date: March 29, 2018Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Yoko FUJIWARA, Takashi YASUKOCHI, Yuka TAKAGI