Abstract: The invention is a transdermal patch containing a noradrenergic and specific serotonergic antidepressant (NaSSA) such as mirtazapine or the like as the active ingredient therein, and capable of transdermally and quantitatively administering the active ingredient. Further, the transdermal patch of the invention exhibits a sufficient therapeutical effect, can suppress side effects that are problematic in oral administration, improves patient compliance and quality of life (QOL), and can solve various problems. Preferably, the patch provided by the invention contains the active ingredient in an amount of from 2 to 30% by mass relative to the drug-containing layer.

Abstract: It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax.

Abstract: It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax.

Abstract: A network monitoring and controlling apparatus for monitoring and controlling a transmission network formed by a plurality of transmission apparatus includes: a path information storing unit for storing path information; a quality information periodic collection unit for periodically collecting quality information; a quality deterioration detecting unit for determining whether or not quality of the path is deteriorated; a path via point searching unit searching the path information storing unit and obtaining information on a path via points of the path deteriorated in quality; a path via point quality information collection unit for collecting quality information of channels corresponding to the path via points; and a quality deterioration point identifying unit for determining whether or not a deteriorated path via point is present.

Abstract: A vacuum molding method for manufacturing a molded article that has a substrate material and a covering material may includes positioning the substrate material and the covering material between a first molding surface of a first die and a second molding surface of a second die, and closing the first and second dies. The die closing step comprises engaging at least a portion of the periphery of the second die with the first die with interleaving the covering material and the substrate material therebetween.

Abstract: It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax.

Abstract: A network monitoring and controlling apparatus for monitoring and controlling a transmission network formed by a plurality of transmission apparatus includes: a path information storing unit for storing path information; a quality information periodic collection unit for periodically collecting quality information; a quality deterioration detecting unit for determining whether or not quality of the path is deteriorated; a path via point searching unit searching the path information storing unit and obtaining information on a path via points of the path deteriorated in quality; a path via point quality information collection unit for collecting quality information of channels corresponding to the path via points; and a quality deterioration point identifying unit for determining whether or not a deteriorated path via point is present.