Patents by Inventor Takashi Yusa

Takashi Yusa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4012429
    Abstract: Prostanoic acid derivatives having the formula ##STR1## wherein A represents a straight or branched alkylene group having from one to 5 carbon atoms, R.sup.1 represents a straight or branched alkyl group having from 4 to 10 carbon atoms and R.sup.2 represents hydrogen atom or a straight or branched alkyl group having from one to 6 carbon atoms and pharmaceutically acceptable salts thereof.The compounds are useful as oxytocic agents and agents inhibiting the secretion of gastric acid and may be prepared by oxidizing a compound having the formula ##STR2## wherein A, R.sup.1 and R.sup.2 are the same as above, R.sup.3 and R.sup.4 are the same or different and each represents a protecting group for the hydroxyl group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as above, removing the hydroxyl-protecting group from the latter compound and, if appropriate, salifying the product thus obtained.
    Type: Grant
    Filed: April 3, 1974
    Date of Patent: March 15, 1977
    Assignee: Sankyo Company Limited
    Inventors: Kiyoshi Sakai, Osamu Oda, Takashi Yusa, Mitsuo Yamazaki, Masaaki Sasaki, Kazuhiko Sasagawa
  • Patent number: 3996263
    Abstract: Prostanoic acid derivatives having the formula ##STR1## wherein A represents an alkylene group having from 4 to 8 carbon atoms, R.sup.1 represents an alkyl group having from one to 5 carbon atoms, R.sup.2 and R.sup.3 may be the same or different and each represents hydrogen atom or an alkyl group having from one to 4 carbon atoms and R.sup.4 represents hydrogen atom or an alkyl group having from one to 4 carbon atoms and the pharmaceutically acceptable salts thereof and also relates to a process for the preparation thereof.The compounds are useful as anti-ulcerogenic agents and may be prepared by reducing a compound having the formula ##STR2## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same above and Z represents a carbonyl-protecting group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Z are the same as above and removing the carbonyl-protecting group from the latter compound.
    Type: Grant
    Filed: May 5, 1975
    Date of Patent: December 7, 1976
    Assignee: Sankyo Company Limited
    Inventors: Kiyoshi Sakai, Takashi Yusa, Junya Ide, Mitsuo Yamazaki, Shinsaku Kobayashi
  • Patent number: 3983152
    Abstract: Prostanoic acid derivatives having the formula ##SPC1##Wherein A represents an alkylene group having from 4 to 8 carbon atoms, R.sup.1 represents an alkyl group having from 4 to 10 carbon atoms, R.sup.2 represents hydrogen atom or an alkyl group having from one to 6 carbon atoms and R.sup.3 represents hydrogen atom or an alkoxycarbonyl group having from one to 6 carbon atoms in the alkyl moiety and the pharmaceutically acceptable salts thereof and also relates to a process for the preparation thereof.The compounds are useful as oxytocic agents and may be prepared by reducing the compound having the formula ##SPC2##Wherein A, R.sup.1, R.sup.2 and R.sup.3 are the same as above and Z represents a carbonyl-protecting group with a metal hydride complex in the presence or absence of an inert organic solvent to give a compound having the formula ##SPC3##Wherein A, R.sup.1, R.sup.2, R.sup.3 and Z are the same as above and removing the carbonyl-protecting group of the latter compound.
    Type: Grant
    Filed: August 6, 1973
    Date of Patent: September 28, 1976
    Assignee: Sankyo Company Limited
    Inventors: Osamu Oda, Kiyoshi Sakai, Takashi Yusa, Hamako Katano
  • Patent number: 3971825
    Abstract: New prostaglandin-like compounds, having brochodilating activity, of formula ##SPC1##(wherein A represents a direct bond or an alkylene group and R.sup.1 represents an alkyl group) and their pharmaceutically acceptable salts are prepared by oxidizing compounds of formula ##SPC2##(wherein R.sup.2 represents hydrogen or a carboxyl-protecting group, and R.sup.3 represents a hydroxyl-protecting group), removing protecting groups from the product and, when appropriate, salifying the compound obtained.
    Type: Grant
    Filed: November 26, 1974
    Date of Patent: July 27, 1976
    Assignee: Sankyo Company Limited
    Inventors: Kiyoshi Sakai, Takashi Yusa, Kenji Inoue