Patents by Inventor Takatoshi Furukawa
Takatoshi Furukawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117346Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.Type: ApplicationFiled: October 9, 2020Publication date: April 11, 2024Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company LimitedInventors: Takanori Yokota, Tetsuya Nagata, Hiroki Yamada, Hideki Furukawa, Takatoshi Yogo, Kenichi Miyata, Akio Uchida, Naoki Tomita
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Patent number: 11286695Abstract: A vehicle door handle mounting structure (1) includes: a vehicle door (3) including a decoration member (5) mounted on a front side of an outer panel (31) and having a coupling portion (522) that is placed in an opening (312) of the outer panel (31); a door handle (4) mounted in the decoration member (5); and a bracket (9) coupled to the coupling portion (522) from a back side of the outer panel (31) and, together with the decoration member (5), holding the outer panel (31) therebetween.Type: GrantFiled: November 30, 2018Date of Patent: March 29, 2022Assignee: MAZDA MOTOR CORPORATIONInventors: Toshihide Moriwaki, Takatoshi Furukawa, Jiyou Piao, Takashi Niseki
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Publication number: 20200330561Abstract: Object: To provide a composition for treatment of facial nerve palsy having less invasiveness and sufficient therapeutic effect. Resolution means: A composition and a kit for treatment of facial nerve palsy in which a substance having a nerve regeneration effect is carried on a carrier made of a bioabsorbable polymer. In particular, a composition for treatment of facial nerve palsy in which an insulin-like growth factor 1 (IGF-1) is carried on a gelatin sponge and a kit capable of preparing the composition.Type: ApplicationFiled: June 6, 2019Publication date: October 22, 2020Inventors: Seiji KAKEHATA, Tsukasa ITO, Takatoshi FURUKAWA, Motoyasu SUGIYAMA, Takanari GOTO
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Publication number: 20190186178Abstract: A vehicle door handle mounting structure (1) includes: a vehicle door (3) including a decoration member (5) mounted on a front side of an outer panel (31) and having a coupling portion (522) that is placed in an opening (312) of the outer panel (31); a door handle (4) mounted in the decoration member (5); and a bracket (9) coupled to the coupling portion (522) from a back side of the outer panel (31) and, together with the decoration member (5), holding the outer panel (31) therebetween.Type: ApplicationFiled: November 30, 2018Publication date: June 20, 2019Applicant: MAZDA MOTOR CORPORATIONInventors: Toshihide MORIWAKI, Takatoshi FURUKAWA, Jiyou PIAO, Takashi NISEKI
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Patent number: 8967120Abstract: An engine control system controls an internal combustion engine so that some of a plurality of cylinders in a multi-cylinder internal combustion engine are made to rest and reduced-cylinder operation takes place. Each cylinder comprises a piston, an intake valve and an exhaust valve. In a resting cylinder during reduced-cylinder operation, when the piston moves downwards, the engine control system opens both the intake valve and the exhaust valve, and when the piston moves upwards, the engine control system opens the intake valve and closes the exhaust valve.Type: GrantFiled: September 21, 2012Date of Patent: March 3, 2015Assignee: Hino Motors, Ltd.Inventors: Takatoshi Furukawa, Hideki Kato, Shotaro Iikubo
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Publication number: 20140299097Abstract: An engine control system controls an internal combustion engine so that some of a plurality of cylinders in a multi-cylinder internal combustion engine are made to rest and reduced-cylinder operation takes place. Each cylinder comprises a piston, an intake valve and an exhaust valve. In a resting cylinder during reduced-cylinder operation, when the piston moves downwards, the engine control system opens both the intake valve and the exhaust valve, and when the piston moves upwards, the engine control system opens the intake valve and closes the exhaust valve.Type: ApplicationFiled: September 21, 2012Publication date: October 9, 2014Inventors: Takatoshi Furukawa, Hideki Kato, Shotaro Iikubo
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Patent number: 7765800Abstract: Excessive generation NO2 by oxidation catalyst arrangement upstream of a selective reduction catalyst is suppressed to prevent falling of NOx reduction rate. A selective reduction catalyst 4 capable of selectively reacting NOx with ammonia even in the presence of oxygen is incorporated in an exhaust pipe 3 from an engine 1. A pair of oxidation catalysts 5A and 5B are arranged in parallel with each other and upstream of the selective reduction catalyst. In an operation condition with low exhaust temperature, amounts of the exhaust gas 2 distributed to the oxidation catalysts 5A and 5B are adjusted so as to make NO/NO2 ratio in the exhaust gas 2 to about 1-1.5.Type: GrantFiled: August 22, 2005Date of Patent: August 3, 2010Assignee: Hino Motors, Ltd.Inventors: Ichiro Tsumagari, Takatoshi Furukawa, Yoshihide Takenaka, Koichi Machida, Shinya Sato
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Publication number: 20090145114Abstract: Even in a vehicle with travel pattern of continuing operational status with low exhaust temperature, a satisfactory NOx reduction effect can be attained even at exhaust temperature lower than that required conventionally therefor. In an exhaust emission control device with selective reduction catalyst 10 incorporated in an exhaust pipe 9, ammonia being added upstream of the catalyst 10 for reduction and purification of NOx, the device comprises an ammonia generator 12 with a vessel 15 for holding urea water 23a and with an electrode 16 for generation of ammonia 13a, 13b through action of plasma on the urea water 23a in the vessel, the ammonia 13a, 13b generated in the generator 12 being fed upstream of the catalyst 10.Type: ApplicationFiled: November 17, 2005Publication date: June 11, 2009Applicant: HINO MOTORS LTD.Inventors: Shinya Sato, Takatoshi Furukawa
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Patent number: 7497889Abstract: Arranged within a cylindrical housing are capturing cells each including a cylindrical outer electrode capable of capturing particulates and an inner electrode inserted into the outer electrode and lined at its outer surface with a dielectric. A divergent exhaust unit is arranged on an end of the housing so as to guide exhaust to interiors in the respective capturing cells. A convergent exhaust unit is arranged on the other end of the housing so as to communicate with a gap between an inner surface of the housing and outer surfaces of the outer electrodes in the respective cells. The inner and outer electrodes are connected to an electric discharge controller.Type: GrantFiled: June 2, 2004Date of Patent: March 3, 2009Assignee: Hino Motors, Ltd.Inventors: Takatoshi Furukawa, Yoshihide Takenaka, Koichi Machida
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Publication number: 20080118410Abstract: An exhaust emission control device with a plasma generator received in a filter casing incorporated in an exhaust pipe for capturing particulates and capable of conducting electric discharge so as to generate plasma in the exhaust gas at a capturing place and with a power supply for impressing voltage on the plasma generator. The plasma generator is unitized and arranged in plurality. A control switch is provided for sequential changeover of the connection of the power supply to the plural units of the plasma generator. A processing capability comparable to a single, large-sized plasma generator is obtained while increase in size of the power supply is prevented.Type: ApplicationFiled: October 27, 2005Publication date: May 22, 2008Inventors: Takatoshi Furukawa, Koichi Machida, Ichiro Tsumagari, Yoshihide Takenaka
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Patent number: 7364606Abstract: Provided are a hollow inner electrode constituted by an electrically conductive filter capable of capturing particulates, a cylindrical outer electrode circumferentially surrounding the electrode, a housing incorporated in a flow passage of exhaust and accommodating the electrodes and, a temperature sensor for detecting temperature of the exhaust and an electric discharge controller for controlling electric power to be distributed to the electrodes and on the basis of a detected value of the temperature sensor. When the temperature of the exhaust obtained by the temperature sensor is lowered, electric power necessary for generation of discharge plasma is distributed by the discharge controller to the electrodes and, thereby oxidizing the particulates captured by the electrode to reduce electricity consumption.Type: GrantFiled: June 2, 2004Date of Patent: April 29, 2008Assignee: Hino Motors, Ltd.Inventors: Masatoshi Shimoda, Koichi Machida, Takatoshi Furukawa
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Publication number: 20080069744Abstract: Provided are an electrically conductive pipe 12 providing an earth electrode, a mixed gas flow passage 14 which guides a mixed gas of fuel with air into the conductive pipe 12 and a high voltage electrode which impresses high voltage between the same and the conductive pipe 12 as the earth electrode to generate plasma for reformation of the fuel guided from the flow passage 14 into the conductive pipe 12 so as to efficiently perform the reformation of the fuel which can be effectively utilized for a field of, for example, reduction of a NOx-occlusion reduction catalyst and of a fuel cell.Type: ApplicationFiled: October 3, 2005Publication date: March 20, 2008Applicant: Hino Motors LTD.Inventors: Koichi Machida, Takatoshi Furukawa
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Publication number: 20070243115Abstract: Excessive generation NO2 by oxidation catalyst arrangement upstream of a selective reduction catalyst is suppressed to prevent falling of NOx reduction rate. A selective reduction catalyst 4 capable of selectively reacting NOx with ammonia even in the presence of oxygen is incorporated in an exhaust pipe 3 from an engine 1. A pair of oxidation catalysts 5A and 5B are arranged in parallel with each other and upstream of the selective reduction catalyst. In an operation condition with low exhaust temperature, amounts of the exhaust gas 2 distributed to the oxidation catalysts 5A and 5B are adjusted so as to make NO/NO2 ratio in the exhaust gas 2 to about 1-1.5.Type: ApplicationFiled: August 22, 2005Publication date: October 18, 2007Applicant: HINO MOTORS, LTD.Inventors: Ichiro Tsumagari, Takatoshi Furukawa, Yoshihide Takenaka, Koichi Machida, Shinya Sato
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Publication number: 20070017371Abstract: Arranged within a cylindrical housing 1 are capturing cells 2 each including a cylindrical outer electrode 7 capable of capturing particulates and an inner electrode 6 inserted into the outer electrode and lined at its outer surface with a dielectric 5. Exhaust divergent means 3 is arrange on an end of the housing 1 so as to guide exhaust G to interiors in the respective capturing cells 2; exhaust convergence means 4 is arranged on the other end of the housing 1 so as to communicate with a gap 14 between an inner surface of the housing and outer surfaces of the outer electrodes 7 in the respective cells 2. The inner and outer electrodes 6 and 7 are connected to an electric discharge controller 15. Thus, provided is an exhaust emission control device with high removal efficiency of particulates and with easiness in maintenance.Type: ApplicationFiled: June 2, 2004Publication date: January 25, 2007Applicant: Hino Motors, Ltd.Inventors: Takatoshi Furukawa, Yoshihide Takenaka, Koichi Machida
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Publication number: 20060249024Abstract: Provided are a hollow inner electrode 5 constituted by an electrically conductive filter capable of capturing particulates, a cylindrical outer electrode 6 circumferentially surrounding the electrode 5, a housing 4 incorporated in a flow passage of exhaust G and accommodating the electrodes 5 and 6, a temperature sensor 2 for detecting temperature of the exhaust G and an electric discharge controller 3 for controlling electric power to be distributed to the electrodes 5 and 6 on the basis of a detected value of the temperature sensor 2. When the temperature of the exhaust G obtained by the temperature sensor 2 is lowered, electric power necessary for generation of discharge plasma is distributed by the discharge controller 3 to the electrodes 5 and 6, thereby oxidizing the particulates captured by the electrode 5 to reduce electricity consumption.Type: ApplicationFiled: June 2, 2004Publication date: November 9, 2006Applicant: HINO MOTORS LTD.Inventors: Masatoshi Shimoda, Koichi Machida, Takatoshi Furukawa