Patents by Inventor Takatoshi KAYA
Takatoshi KAYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230021481Abstract: An object of the present invention is to provide a standard substance for quantification of PSA having a specific sugar chain that can be used in a general purpose quantification, wherein the standard substance has less unbalanced sugar chain expression patterns, can be manufactured with high reproducibility, and enables the quantification of patient's sample comprising a high concentration of PSA, and preparation method therefor, standard solution for PSA quantification, and PSA quantification method. The standard substance comprises a compound having the structure of a PSA with a sugar chain represented by any of the following formulae A to D, and is isolated and purified from a natural product, chemically or enzymatically altered from a natural product, or the compound is artificially synthesized.Type: ApplicationFiled: November 10, 2020Publication date: January 26, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Tomonori KANEKO, Takatoshi KAYA, Makiko OTANI
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Patent number: 11408817Abstract: The detection system according to the present invention has a detection chip, a light source, and a detection unit. The detection chip has a housing that has an opening at an upper portion, and a reaction field for trapping a substance to be detected, the reaction field being arranged on an inner surface of the side walls included in the housing. The light source irradiates the detection chip with light from the outside such that evanescent light or surface plasmon resonance is generated under the reaction field. The detection unit detects light which is emitted from the detection chip when the light source irradiates the detection chip with light, and the amount of which changes depending on the amount of the substance to be detected trapped in the reaction field.Type: GrantFiled: July 24, 2017Date of Patent: August 9, 2022Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Tomonori Kaneko, Kosuke Nagae, Takatoshi Kaya, Yukito Nakamura
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Patent number: 11224879Abstract: An inspection chip according to the present invention is an inspection chip for stirring liquid by a circular movement of a bottom surface end, including a well main body for accommodating the liquid and a side wall member arranged on a side surface of the well main body. The bottom surface end has a bottom surface structure in contact with a rotating member for allowing the bottom surface end to perform the circular movement in a position leaning from a center line of the well main body toward the side wall member.Type: GrantFiled: February 6, 2018Date of Patent: January 18, 2022Assignee: Konica Minolta, Inc.Inventors: Takatoshi Kaya, Tomonori Kaneko
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Publication number: 20210356386Abstract: The detection system according to the present invention has a detection chip, a light source, and a detection unit. The detection chip has a housing that has an opening at an upper portion, and a reaction field for trapping a substance to be detected, the reaction field being arranged on an inner surface of the side walls included in the housing. The light source irradiates the detection chip with light from the outside such that evanescent light or surface plasmon resonance is generated under the reaction field. The detection unit detects light which is emitted from the detection chip when the light source irradiates the detection chip with light, and the amount of which changes depending on the amount of the substance to be detected trapped in the reaction field.Type: ApplicationFiled: July 24, 2017Publication date: November 18, 2021Inventors: Tomonori KANEKO, Kosuke Nagae, Takatoshi Kaya, Yukito Nakamura
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Patent number: 11169090Abstract: The present invention is to provide a diffracted light removal slit and an optical sample detection system including the same, in which diffracted light of excitation light can be reliably removed without affecting reflected light of the excitation light in a sample detection device utilizing the reflected light of the excitation light. A diffracted light removal slit is provided between a light source unit and an excitation light reflector in an optical sample detection system that emits excitation light from the light source unit and also performs predetermined measurement using reflected light of the excitation light reflected at the excitation light reflector. The diffracted light removal slit includes: a main portion provided in a direction substantially perpendicular to an optical path of the excitation light; and a sidewall portion extending from an end portion of the main portion and inclined toward an upstream side in an optical path direction of the excitation light.Type: GrantFiled: September 20, 2018Date of Patent: November 9, 2021Assignee: KONICA MINOLTA, INC.Inventors: Yukito Nakamura, Takatoshi Kaya
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Publication number: 20210318317Abstract: The present invention provides a method for acquiring auxiliary information useful to assist a diagnosis or treatment of prostate cancer. The method for acquiring auxiliary information of the present invention is a method for acquiring auxiliary information to assist a diagnosis or treatment of prostate cancer, and includes a step (C) of dividing a concentration value of a prostate specific antigen having a ?-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain, contained in a sample derived from a living body, by a volume value of prostate of the living body to calculate the concentration value of the GalNAc-PSA per prostate volume.Type: ApplicationFiled: September 25, 2019Publication date: October 14, 2021Inventors: Tomonori KANEKO, Takatoshi KAYA, Chikara OHYAMA, Tohru YONEYAMA, Yuki TOBISAWA, Osamu OGAWA, Takahiro INOUE
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Patent number: 11137403Abstract: The present invention provides methods that are for acquiring various types of supplementary information used for diagnosis or treatment of prostate cancer, and that can be implemented in a less-invasive manner at a low cost. Provided are, by measuring the content of prostate specific antigen (PSA) having a ?-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a specimen, and comparing the measured value with a threshold value, (1) a method for estimating whether a Gleason score (primary pattern and secondary pattern) is not less than or less than a prescribed value, (2) a method for estimating whether the pathological stage (pT) is not less than or less than a prescribed value, and (3) a method for acquiring information for assessment indicating diagnosis or treatment should be actively conducted because a GS at gross total removal is expected to be higher than a GS at biopsy.Type: GrantFiled: November 29, 2017Date of Patent: October 5, 2021Assignees: Konica Minolta, Inc., HIROSAKI UNIVERSITYInventors: Tomonori Kaneko, Takatoshi Kaya, Chikara Ohyama, Tohru Yoneyama, Yuki Tobisawa
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Patent number: 11105807Abstract: Provided is a method of obtaining an index value used for pathological tissue diagnosis of prostate cancer, which method has low invasiveness and can be performed at a low cost. The method is a method of estimating a Gleason score that represents the malignancy of prostate cancer, which method includes: measuring the content of a prostate-specific antigen having an N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a sample; and estimating that the Gleason score is 7 or higher when the thus measured value is larger than a threshold value, or estimating that the Gleason score is 6 or lower when the measured value is smaller than a threshold value. The prostate-specific antigen is preferably quantified by a method including the step of binding a molecule having an affinity for ?-N-acetylgalactosamine residue, such as Wisteria floribunda lectin, soybean agglutinin, Vicia Villosa lectin or an anti-?-N-acetylgalactosamine antibody, to the prostate-specific antigen.Type: GrantFiled: September 2, 2016Date of Patent: August 31, 2021Assignee: KONICA MINOLTA, INC.Inventors: Tomonori Kaneko, Takatoshi Kaya
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Patent number: 10976250Abstract: Provided is a position detection method and a position detection device for detecting a position of a sensor chip and obtaining relative positional information between a well member and a prism as for a well chip type sensor chip in which the well member is provided on a prism. By applying measurement light to the sensor chip while changing a distance between the sensor chip and a measurement light irradiation unit and detecting reflected light traveling in a predetermined direction out of the reflected light generated when the measurement light is reflected by the sensor chip, at least any one of the position of the sensor chip and the relative position between a dielectric member and a sample solution holding member is detected on the basis of a change in intensity of the detected reflected light.Type: GrantFiled: January 16, 2018Date of Patent: April 13, 2021Assignee: KONICA MINOLTA, INC.Inventors: Yukito Nakamura, Takatoshi Kaya, Kosuke Nagae
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Publication number: 20200408753Abstract: An object of the present invention is to provide, in order to quantify a detection target substance contained in a specimen, a specimen diluent capable of reducing an influence of contaminants, that is, noise with respect to a quantitative value of a detection target to obtain favorable signal sensitivity, a method for preparing a sample, a sample, and a sandwich method. A specimen diluent of the present invention is a specimen diluent used in a sandwich method, the specimen diluent containing 10 mM to 500 mM of a compound having a structure represented by formula (I) and 10 mM to 500 mM of a compound having a thiol group.Type: ApplicationFiled: February 21, 2019Publication date: December 31, 2020Inventors: Hidetaka NINOMIYA, Tomonori KANEKO, Shun KOJIMA, Takatoshi KAYA
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Publication number: 20200386778Abstract: A liquid delivery system according to the present invention is a liquid delivery system for supplying liquid to an inspection chip formed of a well main body for accommodating the liquid and a side wall member arranged on a side surface of the well main body or recovering the liquid present in the inspection chip via a liquid delivery tool, the system including a conveyance unit which conveys the liquid delivery tool, and a control unit which controls such that the liquid delivery tool does not pass through a region on a side on which the side wall member is arranged of the inspection chip.Type: ApplicationFiled: February 6, 2018Publication date: December 10, 2020Applicant: Konica Minolta, Inc.Inventors: Takatoshi KAYA, Tomonori KANEKO
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Publication number: 20200319104Abstract: The present invention is to provide a diffracted light removal slit and an optical sample detection system including the same, in which diffracted light of excitation light can be reliably removed without affecting reflected light of the excitation light in a sample detection device utilizing the reflected light of the excitation light. A diffracted light removal slit is provided between a light source unit and an excitation light reflector in an optical sample detection system that emits excitation light from the light source unit and also performs predetermined measurement using reflected light of the excitation light reflected at the excitation light reflector. The diffracted light removal slit includes: a main portion provided in a direction substantially perpendicular to an optical path of the excitation light; and a sidewall portion extending from an end portion of the main portion and inclined toward an upstream side in an optical path direction of the excitation light.Type: ApplicationFiled: September 20, 2018Publication date: October 8, 2020Inventors: Yukito NAKAMURA, Takatoshi KAYA
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Publication number: 20200256796Abstract: A first frame having a first through-hole is arranged on a support so that one opening of the first through-hole is closed. A liquid containing a capturer for capturing a substance to be detected is fed into the first through-hole, and the capturer is immobilized on the support exposed in the first through-hole. After removing the liquid from the support, a second frame having the second through-hole is arranged on the support in the first through-hole so that one opening of the second through-hole is closed.Type: ApplicationFiled: April 28, 2020Publication date: August 13, 2020Applicant: KONICA MINOLTA, INC.Inventors: Yukito NAKAMURA, Takatoshi KAYA, Tomonori KANEKO, Kosuke NAGAE, Hiroshi HIRAYAMA
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Patent number: 10697959Abstract: The present invention provides a sandwich assay for quantifying a glycoprotein, which is a substance to be detected, in a sample using a labeled lectin, wherein the effect attributed to a contaminant, namely noise on the quantified value of the substance to be detected, is suppressed by introduction of a simple treatment. The sandwich assay includes a treatment for inhibiting the binding of the labeled lectin to a sugar chain carried by the contaminant non-specifically adsorbed to the measurement region, which contaminant is contained in the sample and which sugar chain is the same as that of the substance to be detected.Type: GrantFiled: June 1, 2015Date of Patent: June 30, 2020Assignee: KONICA MINOLTA, INC.Inventors: Tomonori Kaneko, Takatoshi Kaya
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Patent number: 10690596Abstract: The surface plasmon-enhanced fluorescence measurement device has: a light source that irradiates the diffraction grating with a linearly polarized excitation light; a rotating part that changes the direction of the optical axis of the excitation light with respect to the diffraction grating when seen in plan view, or changes the polarization direction of the excitation light with respect to the diffraction grating; a polarizer that extracts linearly polarized light from the fluorescence emitted from the fluorescent substance; and a light detection unit that detects the linearly polarized light extracted by the polarizer.Type: GrantFiled: December 1, 2015Date of Patent: June 23, 2020Assignee: Konica Minolta, Inc.Inventors: Yukito Nakamura, Kosuke Nagae, Takatoshi Kaya
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Patent number: 10677731Abstract: A first frame having a first through-hole is arranged on a support so that one opening of the first through-hole is closed. A liquid containing a capturer is fed into the first through-hole, and a capturer is immobilized on the support exposed in the first through-hole. After removing the liquid from the support, a second frame having the second through-hole is arranged on the support in the first through-hole so that one opening of the second through-hole is closed.Type: GrantFiled: April 5, 2016Date of Patent: June 9, 2020Assignee: KONICA MINOLTA, INC.Inventors: Yukito Nakamura, Takatoshi Kaya, Tomonori Kaneko, Kosuke Nagae, Hiroshi Hirayama
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Publication number: 20200150035Abstract: A measurement device is for measuring a sample arranged on a thick film transparent medium. In the measurement device, a light projecting surface, a light receiving surface, the thick film transparent medium, and a sample are set so as to satisfy the following formula (?) for eliminating noise light reflected from a back surface of the thick film transparent medium: h<(L/n3)·?((2H/D2)·(2H/D2)?n3·n3+1) . . . Formula (?). In formula (?), h denotes a distance from the light receiving surface to the sample, L denotes a half of an interval between the light projecting surface and the light receiving surface, n3 denotes a refractive index of the thick film transparent medium, H denotes a thickness of the thick film transparent medium, and D2 denotes an aperture of the light receiving surface.Type: ApplicationFiled: April 20, 2018Publication date: May 14, 2020Inventors: Hidetaka NINOMIYA, Yukito NAKAMURA, Takatoshi KAYA
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Publication number: 20190383818Abstract: The present invention provides methods that are for acquiring various types of supplementary information used for diagnosis or treatment of prostate cancer, and that can be implemented in a less-invasive manner at a low cost. Provided are, by measuring the content of prostate specific antigen (PSA) having a ?-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a specimen, and comparing the measured value with a threshold value, (1) a method for estimating whether a Gleason score (primary pattern and secondary pattern) is not less than or less than a prescribed value, (2) a method for estimating whether the pathological stage (pT) is not less than or less than a prescribed value, and (3) a method for acquiring information for assessment indicating diagnosis or treatment should be actively conducted because a GS at gross total removal is expected to be higher than a GS at biopsy.Type: ApplicationFiled: November 29, 2017Publication date: December 19, 2019Inventors: Tomonori KANEKO, Takatoshi KAYA, Chikara OHYAMA, Tohru YONEYAMA, Yuki TOBISAWA
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Publication number: 20190376974Abstract: The present invention relates to a method for acquiring auxiliary information for diagnosis and treatment (medical care) of prostate cancer. A method for acquiring medical care auxiliary information for estimating a risk of prostate cancer recurrence with a specimen of prostate tissue, wherein an at least three-stage evaluation score is used to express a quantity of biological material in a tumor site of the specimen, the biological material having a ?-N-acetylgalactosamine residue at a nonreducing terminal of a sugar chain.Type: ApplicationFiled: November 29, 2017Publication date: December 12, 2019Inventors: TOMONORI KANEKO, TAKATOSHI KAYA, CHIKARA OHYAMA, TOHRU YONEYAMA, YUKI TOBISAWA
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Patent number: 10495575Abstract: The present invention pertains to a surface plasmon enhanced fluorescence analysis device and a surface plasmon enhanced fluorescence measurement method which use GC-SPFS and make it possible to detect a substance to be detected with high sensitivity. This surface plasmon enhanced fluorescence measurement device has: a light source for irradiating the diffraction grating of a chip with excited light; a polarizer for removing linearly polarized light from fluorescent light emitted from a fluorescent substance on the diffraction grating; and a photodetector for detecting the linearly polarized light removed by the polarizer.Type: GrantFiled: April 8, 2014Date of Patent: December 3, 2019Assignee: KONICA MINOLTA, INC.Inventors: Yukito Nakamura, Takatoshi Kaya, Kosuke Nagae, Akitoshi Nozaki, Fumio Nagai, Ryouta Ishikawa, Akiyuki Namatame