Abstract: Dysregulated expression of microRNAs (miRNAs) has emerged as a hallmark feature in human cancers. Aspects of the disclosure relate to methods for selecting optimal therapy for a patient from several alternative treatment options. A major clinical challenge in cancer treatment is to identify the subset of patients who will benefit from a therapeutic regimen, both in metastatic and adjuvant settings. The number of anti-cancer drugs and multi-drug combinations has increased substantially in the past decade, however, treatments continue to be applied empirically using a trial-and-error approach. Here methods and compositions are provided to determine the optimal treatment option for cancer patients.

Abstract: A display apparatus of the present disclosure includes: a left eyepiece display unit including a left-eye image display device and a left eyepiece optical system guiding a displayed left-eye display image to a left eye; and a right eyepiece display unit including a right-eye image display device and a right eyepiece optical system guiding a displayed right-eye display image to a right eye, and an image magnification upon observation by both eyes is twice or more. The left eyepiece optical system and the right eyepiece optical system each include a plurality of single lenses, and at least one of the single lenses is a free-form surface lens including a resin material. At least one of the single lenses is arranged in at least one of an eccentric state or a rotated state with respect to an optical axis of the left-eye image display device or the right-eye image display device.

Abstract: There is provided an optical device that provides a high quality image. The optical device includes a first light guiding member that has first through sixth surfaces and a first deflecting means. The first, second, and fifth surfaces are opposed to the third, fourth, and sixth surfaces, respectively. The optical device further includes a second light guiding member that has seventh through twelfth surfaces and a second deflecting means. The seventh, eighth, and eleventh surfaces are opposed to the ninth, tenth, and twelfth surfaces, respectively. Light that enters from the fifth surface is totally reflected within the first light guiding member, is deflected by the first deflecting means, is emitted from the third surface, enters the eighth surface, is totally reflected between the seventh surface and the ninth surface, is deflected by the second deflecting means, and is emitted from the seventh surface.

Abstract: A virtual image display apparatus according to the present disclosure includes: a plurality of image forming elements (11 and 12); and a plurality of eyepiece optical systems (21 and 22). The plurality of image forming elements (11 and 12) includes a first image forming element (11) and a second image forming element (12). The first image forming element (11) outputs a first image to a front region in a visual field of a viewer. The second image forming element (12) outputs a second image to a peripheral region in the visual field of the viewer. The second image is different from the first image. The plurality of image forming elements (11 and 12) outputs a plurality of images to cause an image region of at least a portion of each of the plurality of images to overlap with the first image. The plurality of images includes the first and second images. The plurality of eyepiece optical systems (21 and 22) is provided in association with the plurality of respective image forming elements (11 and 12).

Abstract: An observation optical system according to the present invention includes a reflective optical device (30), a first lens group (10), and a second lens group (20). The reflective optical device (30) includes at least one reflection surface (31). The first lens group (10) is disposed at a position closer to an entrance pupil (E.P.) than the reflective optical device (30). The first lens group (10) forms an intermediate image (40) of a virtual image on the reflection surface (31) or at a position closer to the entrance pupil (E.P.) than the reflection surface (31). The intermediate image (40) of the virtual image corresponds to an image displayed on an image display unit (2). The second lens group (20) is disposed on an optical path after light passes through the first lens group (10), the intermediate image (40), and the reflective optical device (30) in order in a case where ray tracing is performed from an entrance pupil (E.P.) side.

Abstract: An eyepiece according to the present disclosure includes a first lens and a second lens that are opposed to each other. The first lens includes a first Fresnel lens surface formed at least in a peripheral region of a lens surface that is opposed to the second lens. The second lens includes a second Fresnel lens surface formed at least in a peripheral region of a lens surface that is opposed to the first lens.

Abstract: A display apparatus of the present disclosure includes an eyepiece display unit including an image display device and an eyepiece optical system that guides a display image displayed on the image display device to an eye point, in which an image magnification by the eyepiece optical system is twice or more, the eyepiece optical system is a coaxial system including a plurality of single lenses, at least one of the plurality of single lenses is an aspherical lens including a resin material, and the image display device displays, as the display image, an image for correction of distortion and chromatic aberration of magnification generated in the eyepiece optical system.

Abstract: A display apparatus of the present disclosure includes: a left eyepiece display unit including a left-eye image display device and a left eyepiece optical system guiding a displayed left-eye display image to a left eye; and a right eyepiece display unit including a right-eye image display device and a right eyepiece optical system guiding a displayed right-eye display image to a right eye, and an image magnification upon observation by both eyes is twice or more. The left eyepiece optical system and the right eyepiece optical system each include a plurality of single lenses, and at least one of the single lenses is a free-form surface lens including a resin material. At least one of the single lenses is arranged in at least one of an eccentric state or a rotated state with respect to an optical axis of the left-eye image display device or the right-eye image display device.

Abstract: An object of the present invention is to provide an optical device, an image display device, and a display device that can provide an image of high image quality.

Abstract: Dysregulated expression of microRNAs (miRNAs) has emerged as a hallmark feature in human cancers. Aspects of the disclosure relate to methods for selecting optimal therapy for a patient from several alternative treatment options. A major clinical challenge in cancer treatment is to identify the subset of patients who will benefit from a therapeutic regimen, both in metastatic and adjuvant settings. The number of anti-cancer drugs and multi-drug combinations has increased substantially in the past decade, however, treatments continue to be applied empirically using a trial-and-error approach. Here methods and compositions are provided to determine the optimal treatment option for cancer patients.

Abstract: An eyepiece of the present disclosure includes three or more lenses provided in order from side of an eye point toward side of an image. At least two of the three or more lenses configure a cemented lens. One of the three or more lenses is an aspherical lens. The following conditional expressions are satisfied, ??/(tan?1(h/L))?2.2??(1) ???0.698??(2) where “??” is a half value (rad) of a maximum field-of-view angle, “h” is a maximum image height, and “L” is a distance from the eye point to the image.