Abstract: Provided is a device for testing solubility of drugs in gastrointestinal tract. The device for testing solubility includes: a plurality of vessels respectively corresponding to gastrointestinal tract of a living body; digestive juice supply devices supplying digestive juice to the vessel requiring the supply of the digestive juice; liquid delivery paths each being provided between the vessels and extending from an upstream-side vessel to a downstream-side vessel; delivery driving sources applying a fluid force to a mixed liquid of the digestive juice and an oral drug in the liquid delivery paths; and a control device controlling delivery speeds of the delivery driving sources according to a temporal change of a flow rate from an upstream side to a downstream side of the gastrointestinal tract of the living body.

Abstract: Provided is a device for testing solubility of drugs in gastrointestinal tract. The device for testing solubility includes: a plurality of vessels respectively corresponding to gastrointestinal tract of a living body; digestive juice supply devices supplying digestive juice to the vessel requiring the supply of the digestive juice; liquid delivery paths each being provided between the vessels and extending from an upstream-side vessel to a downstream-side vessel; delivery driving sources applying a fluid force to a mixed liquid of the digestive juice and an oral drug in the liquid delivery paths; and a control device controlling delivery speeds of the delivery driving sources according to a temporal change of a flow rate from an upstream side to a downstream side of the gastrointestinal tract of the living body.

Abstract: One object is to provide an electron beam sterilization apparatus including: an inner-surface sterilization chamber (5) including an inner-surface electron beam application device; and a blocking chamber (6) for receiving a preform product (P) from the inner-surface sterilization chamber (5) and blocking X-rays produced by application of the electron beam. The blocking chamber (6) includes an upstream opening (62) and a downstream opening (63) formed therein, the preform product (P) being received through the upstream opening (62) and transferred through the downstream opening (63). The blocking chamber (6) includes: a gripper (74) for gripping the preform product (P); a sterilized rotation table (71) for conveying the gripped preform product (P) in a circular path; and a blocking wall (81) not in contact with the sterilized rotation table (71) and configured to block the X-rays.

Abstract: Electron beams are irradiated to substantially identical sterilization surfaces on a container from a first upstream electron-beam irradiating device and a first downstream electron-beam irradiating device that are spaced with a predetermined distance upstream and downstream on a container carrier path. A sterilization controller controls the sum of electron beam outputs irradiated from the upstream electron-beam irradiating device and the downstream electron-beam irradiating device so as to allow sterilization on the sterilization surfaces of the container.

Abstract: One object is to provide an electron beam sterilization apparatus for sterilizing a preform product (P) by applying an electron beam while conveying the preform product (P), the apparatus comprising: an input star wheel (21) configured to convey the preform product (P) in a circular path; and an outer-surface electron beam application device and an inner-surface electron beam application device configured to apply an electron beam to the preform product (P) being conveyed by the input star wheel (21). A blocking short tube (31) is provided on a lower surface of the star wheel plate (22) of the input star wheel (21) so as to block radioactive rays produced by application of the electron beam and surround a central axis (1v) of the input star wheel (21). The blocking short tube (31) includes a ventilation space (34) formed therein.

Abstract: One object is to provide an electron beam sterilization apparatus for sterilizing a preform product (P) by applying an electron beam while conveying the preform product (P), the apparatus comprising: an input star wheel (21) configured to convey the preform product (P) in a circular path; and an outer-surface electron beam application device and an inner-surface electron beam application device configured to apply an electron beam to the preform product (P) being conveyed by the input star wheel (21). A blocking short tube (31) is provided on a lower surface of the star wheel plate (22) of the input star wheel (21) so as to block radioactive rays produced by application of the electron beam and surround a central axis (1v) of the input star wheel (21). The blocking short tube (31) includes a ventilation space (34) formed therein.

Abstract: One object is to provide an electron beam sterilization apparatus including: an inner-surface sterilization chamber (5) including an inner-surface electron beam application device; and a blocking chamber (6) for receiving a preform product (P) from the inner-surface sterilization chamber (5) and blocking X-rays produced by application of the electron beam. The blocking chamber (6) includes an upstream opening (62) and a downstream opening (63) formed therein, the preform product (P) being received through the upstream opening (62) and transferred through the downstream opening (63). The blocking chamber (6) includes: a gripper (74) for gripping the preform product (P); a sterilized rotation table (71) for conveying the gripped preform product (P) in a circular path; and a blocking wall (81) not in contact with the sterilized rotation table (71) and configured to block the X-rays.

Abstract: An electron beam irradiation apparatus that emits an electron beam into a container, the electron beam irradiation apparatus including: a vacuum housing constituting a vacuum chamber; an electron generator provided in the vacuum housing; a cylindrical nozzle member that is extended from the vacuum housing so as to be inserted into the container and has exit windows on the distal end of the nozzle member, the exit windows being provided for emission of an electron beam generated by the electron generator into the container; and a magnetic shield member for the vacuum chamber and a magnetic shield member for the nozzle member, the magnetic shield members being respectively provided for the vacuum housing and the nozzle member so as to block variable magnetism generated around an electron beam trajectory extended from the electron generator to the exit windows.

Abstract: Provided is a shield used for container sterilization equipment that inserts, from the mouth of a container (B), an irradiation nozzle (En) having an exit window (Ew) on the distal end of the irradiation nozzle (En) and sterilizes the inner surface of the container (B), the irradiation nozzle (En) being surrounded by composite shields (Wi, Wo). A composite shield block (21) forming the composite shields (Wi, Wo) includes a magnetic shield (24) and an X-ray shield (25) that are disposed in the hollow section of a board-shaped shell (22) made of a corrosion resistant material, and an insulating layer (26) that is interposed between one surface of the board-shaped shell (22) and the magnetic shield (24), between the magnetic shield (24) and the X-ray shield (25), and between the X-ray shield (25) and one surface of the board-shaped shell (22).

Abstract: Electron beams are irradiated to substantially identical sterilization surfaces on a container from a first upstream electron-beam irradiating device and a first downstream electron-beam irradiating device that are spaced with a predetermined distance upstream and downstream on a container carrier path. A sterilization controller controls the sum of electron beam outputs irradiated from the upstream electron-beam irradiating device and the downstream electron-beam irradiating device so as to allow sterilization on the sterilization surfaces of the container.

Abstract: Provided is a shield used for container sterilization equipment that inserts, from the mouth of a container (B), an irradiation nozzle (En) having an exit window (Ew) on the distal end of the irradiation nozzle (En) and sterilizes the inner surface of the container (B), the irradiation nozzle (En) being surrounded by composite shields (Wi, Wo). A composite shield block (21) forming the composite shields (Wi, Wo) includes a magnetic shield (24) and an X-ray shield (25) that are disposed in the hollow section of a board-shaped shell (22) made of a corrosion resistant material, and an insulating layer (26) that is interposed between one surface of the board-shaped shell (22) and the magnetic shield (24), between the magnetic shield (24) and the X-ray shield (25), and between the X-ray shield (25) and one surface of the board-shaped shell (22).

Abstract: An electron bears irradiation apparatus that emits am electron beam into a container, the electron beam irradiation apparatus including a vacuum housing constituting a vacuum chamber; an electron generator provided in the vacuum housing; a cylindrical nozzle member that is extended from the vacuum housing so as to be inserted into the container and has exit windows on the distal end of the nozzle member, the exit windows being provided for emission of an electron beard generated by the electron generator into the container; and a magnetic shield member for the vacuum chamber and a magnetic shield member for the nozzle member, the magnetic shield members being respectively provided for the vacuum housing and the nozzle member so as to block variable magnetism generated around an electron beam, trajectory extended from the electron generator to the exit windows.

Abstract: Electron beam sterilization equipment includes an outer-surface sterilization zone Z2 for sterilizing the outer surface of a container B by emitting electron beams when the container B is transported along circular paths L1 and L2; and an inner-surface sterilization zone Z3 for sterilizing the inner surface of the container B. An electron beam irradiator E1 is located near the upstream side of a 1-2 joint J1-2 of the circular paths L1 and L2 disposed in the outer-surface sterilization zone Z2, and a electron beam irradiator E2 is located near the downstream side of the joint. Thus, the electron beam irradiator E1 and the electron beam irradiator E2 are brought close to each other so as to sequentially sterilize the one half outer surfaces and the other half outer surface of the container B.

Abstract: Electron beam sterilization equipment includes an outer-surface sterilization zone Z2 for sterilizing the outer surface of a container B by emitting electron beams when the container B is transported along circular paths L1 and L2; and an inner-surface sterilization zone Z3 for sterilizing the inner surface of the container B. An electron beam irradiator E1 is located near the upstream side of a 1-2 joint J1-2 of the circular paths L1 and L2 disposed in the outer-surface sterilization zone Z2, and a electron beam irradiator E2 is located near the downstream side of the joint. Thus, the electron beam irradiator E1 and the electron beam irradiator E2 are brought close to each other so as to sequentially sterilize the one half outer surfaces and the other half outer surface of the container B.

Abstract: A shield structure for electron beam sterilization equipment. The shield structure satisfies at least one of the following conditions: (I) an outer diameter D4 of an internal circumferential shield S4 is larger than an outer diameter D5 of an internal circumferential shield S5, and (II) an internal circumferential shield ST2 of a circular path LT2 downstream of an entrance trap zone Z1 connected to an outer-surface sterilization zone Z2 has an outer diameter DT2 that is larger than an outer diameter D1 of an internal circumferential shield S1 of a circular path L1 upstream of the outer-surface sterilization zone Z2.

Abstract: A laser emitting section 59A and a laser receiving section 59B for measuring an oxygen concentration are provided on two sides of an inspection area so as to be moved toward and away from a bag-shaped container 1. Gas-filled chambers 61 provided on the end faces of the laser emitting section 59A and the laser receiving section 59B are brought into contact with the gas phase portion of the container 1 to keep a constant thickness of the gas phase portion. A tilting device 81 is provided to press the container 1, which is held by a container holder 16, from both sides with a container pressing member 88 and tilts the container 1 in a vertical plane. When an oxygen concentration is measured, the tilting device 81 tilts the bag-shaped container 1 to measure the gas phase portion at the shoulders of the container 1.

Abstract: A shield structure for electron beam sterilization equipment. The shield structure satisfies at least one of the following conditions: (I) an outer diameter D4 of an internal circumferential shield S4 is larger than an outer diameter D5 of an internal circumferential shield S5, and (II) an internal circumferential shield ST2 of a circular path LT2 downstream of an entrance trap zone Z1 connected to an outer-surface sterilization zone Z2 has an outer diameter DT2 that is larger than an outer diameter D1 of an internal circumferential shield S1 of a circular path L1 upstream of the outer-surface sterilization zone Z2.

Abstract: A laser emitting section 59A and a laser receiving section 59B for measuring an oxygen concentration are provided on two sides of an inspection area so as to be moved toward and away from a bag-shaped container 1. Gas-filled chambers 61 provided on the end faces of the laser emitting section 59A and the laser receiving section 59B are brought into contact with the gas phase portion of the container 1 to keep a constant thickness of the gas phase portion. A tilting device 81 is provided to press the container 1, which is held by a container holder 16, from both sides with a container pressing member 88 and tilts the container 1 in a vertical plane. When an oxygen concentration is measured, the tilting device 81 tilts the bag-shaped container 1 to measure the gas phase portion at the shoulders of the container 1.

Abstract: A non-destructive inspection device for an oxygen concentration in a bag-shaped container includes: right and left affixing plates provided so as to be moved toward and away from the bag-shaped container; a laser emitting section for measuring an oxygen concentration that is provided on one of the affixing plates; and a laser receiving section on the other affixing plate, wherein the end faces of the emitting section and the receiving section have gas-filled chambers that include gas chambers with a constant length and are made of a translucent material. In the measurement of an oxygen concentration, the affixing plates are brought close to each other, the thickness of a gas phase portion is kept constant, and air is removed between the end faces of the emitting section and the receiving section and the surfaces of the container.

Abstract: A non-destructive inspection device for an oxygen concentration in a bag-shaped container includes: right and left affixing plates provided so as to be moved toward and away from the bag-shaped container; a laser emitting section for measuring an oxygen concentration that is provided on one of the affixing plates; and a laser receiving section on the other affixing plate, wherein the end faces of the emitting section and the receiving section have gas-filled chambers that include gas chambers with a constant length and are made of a translucent material. In the measurement of an oxygen concentration, the affixing plates are brought close to each other, the thickness of a gas phase portion is kept constant, and air is removed between the end faces of the emitting section and the receiving section and the surfaces of the container.