Patents by Inventor Takayoshi Hidaka
Takayoshi Hidaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8946303Abstract: To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.Type: GrantFiled: January 19, 2004Date of Patent: February 3, 2015Assignee: Kaneka CorporationInventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20110070213Abstract: The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application.Type: ApplicationFiled: November 24, 2010Publication date: March 24, 2011Applicant: KANEKA CORPORATIONInventors: Kenji FUJII, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Patent number: 7754205Abstract: The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.Type: GrantFiled: May 8, 2002Date of Patent: July 13, 2010Assignee: Kaneka CorporationInventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20090087420Abstract: The present invention provides a composition of a practically usable solution capable of stably maintaining, against oxidation, reduced coenzyme Q, which has not been employed in practice so far because of being liable to undergo oxidation and hydrophobic, a method of preparing the solution and a method of storing the solution. A solution of reduced coenzyme Q which can be stored at a low temperature or room temperature over a long time can be prepared by coating reduced coenzyme Q with liposome made of refined soybean lecithin, etc, and solubilizing, or solubilizing or emulsifying reduced coenzyme Q by using a surfactant at a low temperature.Type: ApplicationFiled: December 4, 2008Publication date: April 2, 2009Applicant: Kaneka CorporationInventors: Kenji FUJII, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Patent number: 7364751Abstract: The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.Type: GrantFiled: October 10, 2002Date of Patent: April 29, 2008Assignee: Kaneka CorporationInventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20060165672Abstract: To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.Type: ApplicationFiled: January 19, 2004Publication date: July 27, 2006Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20060106116Abstract: A method for lessening oxidative stress in vivo in a subject in need thereof, comprising administering to said subject a composition containing a reduced coenzyme Q and an oxidized coenzyme of Q.Type: ApplicationFiled: December 23, 2005Publication date: May 18, 2006Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Patent number: 7015252Abstract: The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease. It was confirmed that by using a composition containing oxidized coenzyme Q and/or reduced coenzyme Q, the amount of urinary 8-hydroxydeoxyquanosine can be decreased in normal or diabetic animals. Also, in histopathological research of the spleens of diabetic rats, it was confirmed that spleen tissue denaturation caused by oxidative stress can be prevented. It was thus found that oxidative stress in vivo can be lessened. According to the present invention, oxidative stress in vivo can be lessened by using a composition containing coenzyme Q as an active ingredient.Type: GrantFiled: October 15, 2002Date of Patent: March 21, 2006Assignee: Kaneka CorporationInventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20050209343Abstract: The present invention provides to intractable skin diseases such as athlete's foot a substance which has a percutaneous absorption promoting effect capable of enhancing the effectiveness of an antifungal agent, etc., and is high in safety to skin which becomes sensitive to irritation because of the diseases. Coenzyme Q, which is known to be highly safe in oral administration, was found to have high safety to skin and a percutaneous absorption promoting effect to an antifungal agent. From this, a useful composition composed of coenzyme Q and an antifungal agent can be provided to athlete's foot which is difficult to be completely cured.Type: ApplicationFiled: March 20, 2003Publication date: September 22, 2005Inventors: Kenji Fenjii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Patent number: 6939897Abstract: The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q10 represented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q10.Type: GrantFiled: July 16, 2004Date of Patent: September 6, 2005Assignee: Kaneka CorporationInventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20050113459Abstract: The present invention provides a composition for improving glucose tolerance to patients having diabetic hyperglycemia and people having pre-diabetes, i.e., abnormal glucose tolerance. The composition helps control the blood glucose level, prevents diabetic complications, and can be administered over a long term due to its high safety. The composition containing a coenzyme Q, in particular, a reduced coenzyme Q10, as the main component improves the impaired glucose tolerance of diabetes patients, satisfactorily controls the blood glucose level, and decreases the blood glycosylated hemoglobin level.Type: ApplicationFiled: March 20, 2003Publication date: May 26, 2005Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20050070610Abstract: The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application.Type: ApplicationFiled: May 9, 2001Publication date: March 31, 2005Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20050070481Abstract: The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.Type: ApplicationFiled: October 10, 2002Publication date: March 31, 2005Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20040248992Abstract: The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy.Type: ApplicationFiled: July 16, 2004Publication date: December 9, 2004Applicant: KANEKA CORPORATIONInventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20040248991Abstract: The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease.Type: ApplicationFiled: April 9, 2004Publication date: December 9, 2004Inventors: Kenji Fujii, Taizo Kawabe, Kanunori Hosoe, Takayoshi Hidaka
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Publication number: 20040126367Abstract: The present invention provides a composition of a practically usable solution capable of stably maintaining, against oxidation, reduced coenzyme Q, which has not been employed in practice so far because of being liable to undergo oxidation and hydrophobic, a method of preparing the solution and a method of storing the solution. A solution of reduced coenzyme Q which can be stored at a low temperature or room temperature over a long time can be prepared by coating reduced coenzyme Q with liposome made of refined soybean lecithin, etc, and solubilizing, or solubilizing or emulsifying reduced coenzyme Q by using a surfactant at a low temperature.Type: ApplicationFiled: October 28, 2003Publication date: July 1, 2004Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20040122109Abstract: The present invention provides a preparation for hair and/or scalp which is effective in growing hair and preventing hair removal and has an excellent skin-care effect on the scalp and high safety. The preparation comprises, as active ingredients, either oxidized coenzyme Q and reduced coenzyme Q or reduced coenzyme Q alone, the total content of oxidized coenzyme Q and reduced coenzyme Q being 0.0001 to 99% by weight based on the whole of the preparation.Type: ApplicationFiled: October 28, 2003Publication date: June 24, 2004Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20040115181Abstract: The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.Type: ApplicationFiled: October 28, 2003Publication date: June 17, 2004Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Publication number: 20040010047Abstract: The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy.Type: ApplicationFiled: July 30, 2003Publication date: January 15, 2004Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
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Patent number: 6362169Abstract: Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.Type: GrantFiled: August 22, 2000Date of Patent: March 26, 2002Assignee: Kaneka CorporationInventors: Kenji Fujii, Katsuji Yamashita, Kazunori Hosoe, Takayoshi Hidaka