Patents by Inventor Takayoshi Hidaka

Takayoshi Hidaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8946303
    Abstract: To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.
    Type: Grant
    Filed: January 19, 2004
    Date of Patent: February 3, 2015
    Assignee: Kaneka Corporation
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20110070213
    Abstract: The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application.
    Type: Application
    Filed: November 24, 2010
    Publication date: March 24, 2011
    Applicant: KANEKA CORPORATION
    Inventors: Kenji FUJII, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Patent number: 7754205
    Abstract: The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: July 13, 2010
    Assignee: Kaneka Corporation
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20090087420
    Abstract: The present invention provides a composition of a practically usable solution capable of stably maintaining, against oxidation, reduced coenzyme Q, which has not been employed in practice so far because of being liable to undergo oxidation and hydrophobic, a method of preparing the solution and a method of storing the solution. A solution of reduced coenzyme Q which can be stored at a low temperature or room temperature over a long time can be prepared by coating reduced coenzyme Q with liposome made of refined soybean lecithin, etc, and solubilizing, or solubilizing or emulsifying reduced coenzyme Q by using a surfactant at a low temperature.
    Type: Application
    Filed: December 4, 2008
    Publication date: April 2, 2009
    Applicant: Kaneka Corporation
    Inventors: Kenji FUJII, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Patent number: 7364751
    Abstract: The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: April 29, 2008
    Assignee: Kaneka Corporation
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20060165672
    Abstract: To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.
    Type: Application
    Filed: January 19, 2004
    Publication date: July 27, 2006
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20060106116
    Abstract: A method for lessening oxidative stress in vivo in a subject in need thereof, comprising administering to said subject a composition containing a reduced coenzyme Q and an oxidized coenzyme of Q.
    Type: Application
    Filed: December 23, 2005
    Publication date: May 18, 2006
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Patent number: 7015252
    Abstract: The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease. It was confirmed that by using a composition containing oxidized coenzyme Q and/or reduced coenzyme Q, the amount of urinary 8-hydroxydeoxyquanosine can be decreased in normal or diabetic animals. Also, in histopathological research of the spleens of diabetic rats, it was confirmed that spleen tissue denaturation caused by oxidative stress can be prevented. It was thus found that oxidative stress in vivo can be lessened. According to the present invention, oxidative stress in vivo can be lessened by using a composition containing coenzyme Q as an active ingredient.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: March 21, 2006
    Assignee: Kaneka Corporation
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20050209343
    Abstract: The present invention provides to intractable skin diseases such as athlete's foot a substance which has a percutaneous absorption promoting effect capable of enhancing the effectiveness of an antifungal agent, etc., and is high in safety to skin which becomes sensitive to irritation because of the diseases. Coenzyme Q, which is known to be highly safe in oral administration, was found to have high safety to skin and a percutaneous absorption promoting effect to an antifungal agent. From this, a useful composition composed of coenzyme Q and an antifungal agent can be provided to athlete's foot which is difficult to be completely cured.
    Type: Application
    Filed: March 20, 2003
    Publication date: September 22, 2005
    Inventors: Kenji Fenjii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Patent number: 6939897
    Abstract: The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q10 represented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q10.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: September 6, 2005
    Assignee: Kaneka Corporation
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20050113459
    Abstract: The present invention provides a composition for improving glucose tolerance to patients having diabetic hyperglycemia and people having pre-diabetes, i.e., abnormal glucose tolerance. The composition helps control the blood glucose level, prevents diabetic complications, and can be administered over a long term due to its high safety. The composition containing a coenzyme Q, in particular, a reduced coenzyme Q10, as the main component improves the impaired glucose tolerance of diabetes patients, satisfactorily controls the blood glucose level, and decreases the blood glycosylated hemoglobin level.
    Type: Application
    Filed: March 20, 2003
    Publication date: May 26, 2005
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20050070610
    Abstract: The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application.
    Type: Application
    Filed: May 9, 2001
    Publication date: March 31, 2005
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20050070481
    Abstract: The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.
    Type: Application
    Filed: October 10, 2002
    Publication date: March 31, 2005
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20040248992
    Abstract: The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy.
    Type: Application
    Filed: July 16, 2004
    Publication date: December 9, 2004
    Applicant: KANEKA CORPORATION
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20040248991
    Abstract: The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 9, 2004
    Inventors: Kenji Fujii, Taizo Kawabe, Kanunori Hosoe, Takayoshi Hidaka
  • Publication number: 20040126367
    Abstract: The present invention provides a composition of a practically usable solution capable of stably maintaining, against oxidation, reduced coenzyme Q, which has not been employed in practice so far because of being liable to undergo oxidation and hydrophobic, a method of preparing the solution and a method of storing the solution. A solution of reduced coenzyme Q which can be stored at a low temperature or room temperature over a long time can be prepared by coating reduced coenzyme Q with liposome made of refined soybean lecithin, etc, and solubilizing, or solubilizing or emulsifying reduced coenzyme Q by using a surfactant at a low temperature.
    Type: Application
    Filed: October 28, 2003
    Publication date: July 1, 2004
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20040122109
    Abstract: The present invention provides a preparation for hair and/or scalp which is effective in growing hair and preventing hair removal and has an excellent skin-care effect on the scalp and high safety. The preparation comprises, as active ingredients, either oxidized coenzyme Q and reduced coenzyme Q or reduced coenzyme Q alone, the total content of oxidized coenzyme Q and reduced coenzyme Q being 0.0001 to 99% by weight based on the whole of the preparation.
    Type: Application
    Filed: October 28, 2003
    Publication date: June 24, 2004
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20040115181
    Abstract: The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.
    Type: Application
    Filed: October 28, 2003
    Publication date: June 17, 2004
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Publication number: 20040010047
    Abstract: The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy.
    Type: Application
    Filed: July 30, 2003
    Publication date: January 15, 2004
    Inventors: Kenji Fujii, Taizo Kawabe, Kazunori Hosoe, Takayoshi Hidaka
  • Patent number: 6362169
    Abstract: Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: March 26, 2002
    Assignee: Kaneka Corporation
    Inventors: Kenji Fujii, Katsuji Yamashita, Kazunori Hosoe, Takayoshi Hidaka