Patents by Inventor Takayuki Hamada
Takayuki Hamada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080287687Abstract: The present invention relates to a production method of a compound represented by the formula (3), which includes reacting a compound represented by the formula (2) with a diphenylmethyl halide compound represented by the formula (1) in the presence of alkali metal alkoxide. According to the method of the present invention, compound (3) can be produced at a high purity and in a high yield. wherein each symbol is as defined in the specification, *1 and *2 each show an asymmetric carbon atom, and the configuration of the asymmetric carbon atom of *1 and *2 is (S,S) or (R,R).Type: ApplicationFiled: October 31, 2007Publication date: November 20, 2008Applicant: AJINOMOTO CO. INCInventors: Takayuki Hamada, Kunisuke Izawa, Vadim A. Soloshonok
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Patent number: 7427688Abstract: The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone and N,N-dimethylformamide, in the presence of a base selected from an alkali metal hydride and an alkali metal t-butoxide to give a diester compound represented by the following formula (3), and then subjecting the diester compound to hydrolysis and decarboxylation to give a diphenylalanine compound represented by the following formula (4). According to the present invention, diphenylalanine compound (4) can be obtained industrially advantageously in a high yield. wherein each symbol is as defined in the specification.Type: GrantFiled: May 10, 2006Date of Patent: September 23, 2008Assignee: Ajinomoto Co., Inc.Inventors: Takayuki Hamada, Masanobu Yatagai
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Publication number: 20080108830Abstract: The present invention relates to a production method of optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof, which includes reacting optically active N-benzylproline (1) with 2-amino-5-chlorobenzophenone (2) in acetonitrile and in the presence of an amide compound and thionyl chloride. According to the method of the present invention, optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof can be conveniently produced at a high purity and in a high yield: wherein * shows an asymmetric carbon atom and the configuration of the asymmetric carbon atom is S or R.Type: ApplicationFiled: October 31, 2007Publication date: May 8, 2008Applicant: AJINOMOTO CO. INCInventors: Takayuki Hamada, Kunisuke Izawa, Vadim Soloshonok
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Patent number: 7321055Abstract: Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3): wherein each symbol is as defined in the specification.Type: GrantFiled: August 4, 2006Date of Patent: January 22, 2008Assignee: Ajinomoto Co., Inc.Inventors: Takayuki Hamada, Masayuki Oshita, Masanobu Yatagai
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Publication number: 20070120702Abstract: A panel instrument to be mounted in a panel board, including: a main body having an outside dimension applicable to a first and a second panel instrument size standards; a display provided on one end of the main body and having an area that occupies a part of a front face of the panel board and is applicable to the first panel instrument size standard; a front panel mounted on a front face of the display; and a rear panel for holding the display with the front panel, wherein the rear panel has: first mounting holes that are provided on one diagonal line of the rear panel and correspond to a mounting hole standard applicable to the second panel instrument size standard; and second mounting holes that are provided on the other diagonal line and correspond to a mounting hole standard applicable to a third panel instrument size standard.Type: ApplicationFiled: November 9, 2006Publication date: May 31, 2007Applicant: Yokogawa Electric CorporationInventors: Takayuki Hamada, Akio Morita, Manabu Aoki
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Patent number: 7217835Abstract: The present invention relates to a method of producing a compound represented by the formula [I] or a salt thereof, which comprises reacting a compound represented by the formula [II] or a salt thereof with a compound represented by the formula [III] or a salt thereof, in the presence of a base, in alcohol, and provides a production method of an O-substituted tyrosine compound, which is superior in productivity, versatility and safety, and economically and industrially useful: wherein each symbol is as defined in the specification.Type: GrantFiled: September 10, 2004Date of Patent: May 15, 2007Assignee: Ajinomoto Co., Inc.Inventors: Takayuki Hamada, Masanobu Yatagai
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Publication number: 20070032658Abstract: Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3): wherein each symbol is as defined in the specification.Type: ApplicationFiled: August 4, 2006Publication date: February 8, 2007Applicant: Ajinomoto Co., Inc.Inventors: Takayuki Hamada, Masayuki Oshita, Masanobu Yatagai
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Patent number: 7145030Abstract: The present invention provides an effective method for the production of optically active N-aryl-?-amino acid compounds, which at the same time is suitable for industrial production. In the method of the present invention optically active sulfonylated ?-hydroxycarboxylic acid compounds, which are readily derived from ?-keto carboxylic acid compounds, are reacted with aromatic amines to produce optically active N-aryl-?-amino acid compounds.Type: GrantFiled: April 19, 2004Date of Patent: December 5, 2006Assignee: Ajinomoto Co., Inc.Inventors: Takayuki Hamada, Kunisuke Izawa
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Publication number: 20060270869Abstract: The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone and N,N-dimethylformamide, in the presence of a base selected from an alkali metal hydride and an alkali metal t-butoxide to give a diester compound represented by the following formula (3), and then subjecting the diester compound to hydrolysis and decarboxylation to give a diphenylalanine compound represented by the following formula (4). According to the present invention, diphenylalanine compound (4) can be obtained industrially advantageously in a high yield. wherein each symbol is as defined in the specification.Type: ApplicationFiled: May 10, 2006Publication date: November 30, 2006Applicant: Ajinomoto Co., Inc.Inventors: Takayuki Hamada, Masanobu Yatagai
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Publication number: 20060270857Abstract: An optically active compound (I) is reacted with compound (II) to give optically active compound (III), which is subjected to alkali hydrolysis and deprotection when R1 is alkyl: wherein X is a chlorine atom and the like, and R1, R2 and R3 are each an alkyl group and the like, or racemic compound (I) is reacted with compound (II) to give racemic compound (III), which is asymmetrically hydrolyzed by an enzyme to perform optical resolution, and subjected to alkali hydrolysis and deprotection: wherein X is a chlorine atom and the like and R1, R2 and R3 are each an alkyl group and the like.Type: ApplicationFiled: May 5, 2006Publication date: November 30, 2006Applicant: Ajinomoto Co., Inc.Inventors: Takayuki Hamada, Masanobu Yatagai
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Publication number: 20050283021Abstract: The present invention relates to a method of producing a compound represented by the formula [I] or a salt thereof, which comprises reacting a compound represented by the formula [II] or a salt thereof with a compound represented by the formula [III] or a salt thereof, in the presence of a base, in alcohol, and provides a production method of an O-substituted tyrosine compound, which is superior in productivity, versatility and safety, and economically and industrially useful: wherein each symbol is as defined in the specification.Type: ApplicationFiled: September 10, 2004Publication date: December 22, 2005Applicant: AJINOMOTO, CO., INC.Inventors: Takayuki Hamada, Masanobu Yatagai
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Patent number: 6888012Abstract: A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an ?-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.Type: GrantFiled: December 18, 2001Date of Patent: May 3, 2005Assignee: Ajinomoto Co., Inc.Inventors: Takayoshi Torii, Takayuki Hamada, Tomoyuki Onishi, Kunisuke Izawa, Takao Ikariya, Ryoji Noyori
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Publication number: 20050032889Abstract: The present invention relates to a method of producing a highly pure crystal, which includes crystallization of a benzenesulfonamide derivative of the following formula (1) using a polar solvent as a good solvent (e.g.Type: ApplicationFiled: June 28, 2004Publication date: February 10, 2005Applicant: AJINOMOTO CO., INCInventors: Shinji Kuroda, Tomoyuki Onishi, Naoko Hirose, Takayuki Hamada
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Publication number: 20040267043Abstract: It is the problems to provide an effective production method for optically active N-aryl-&bgr;-amino acid compounds, which at the same time is suitable for industrial production. By the reaction of optically active sulfonylated &bgr;-hydroxycarboxylic acid compounds, which are easily derived from &bgr;-keto carboxylic acid compounds, with aromatic amines, optically active N-aryl-&bgr;-amino acid compounds are obtained.Type: ApplicationFiled: April 19, 2004Publication date: December 30, 2004Applicant: AJINOMOTO CO., INC.Inventors: Takayuki Hamada, Kunisuke Izawa
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Publication number: 20040082820Abstract: A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an &agr;-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.Type: ApplicationFiled: June 25, 2003Publication date: April 29, 2004Inventors: Takayoshi Torii, Takayuki Hamada, Tomoyuki Onishi, Kunisuki Izawa, Takao Ikariya, Ryoji Noyori
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Publication number: 20030190757Abstract: For the purpose of extremely simply carrying out a pre-treatment such as sample preparation including extraction or concentration of a component of interest in a short time when performing a chromatographic analysis, it is intended that a column configured such that the inside of a narrow tube is provided with a porous body having open pore structures across the entire diameter of the tube and along an appropriate length of the tube is used and a sample containing a substance to be measured is allowed to pass through the column to retain and concentrate the substance to be measured within pores of the porous body in the column, and it is also intended to provide a method in which the above described process is conducted as a micro trap when carrying out the pre-treatment of the chromatographic analysis and then the removed substances are introduced into analytical means, a method in which a sample is introduced into a separation column after narrowing the sample band when introducing the sample into a liquidType: ApplicationFiled: March 24, 2003Publication date: October 9, 2003Inventors: Masahiro Furuno, Masayoshi Ohira, Noritaka Furushima, Takayuki Hamada, Yuka Hiramatsu, Yukihiro Shintani
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Patent number: 6339170Abstract: Optically active N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester useful as an enkephalin inhibitory agent or ACE inhibitory agent can be produced at low cost in an industrial manner, by a method comprising subjecting optically active 2-hydroxymethyl-3-phenylpropionic acid and glycine benzyl ester to condensation to subsequently convert the hydroxyl group into an elimination group, and substituting the elimination group with an acetylthio group.Type: GrantFiled: March 20, 2001Date of Patent: January 15, 2002Assignee: Ajinomoto Co., Inc.Inventors: Takayuki Suzuki, Takayuki Hamada, Kunisuke Izawa
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Publication number: 20010014754Abstract: Optically active N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester useful as an enkephalin inhibitory agent or ACE inhibitory agent can be produced at low cost in an industrial manner, by a method comprising subjecting optically active 2-hydroxymethyl-3-phenylpropionic acid and glycine benzyl ester to condensation to subsequently convert the hydroxyl group into an elimination group, and substituting the elimination group with an acetylthio group.Type: ApplicationFiled: March 20, 2001Publication date: August 16, 2001Applicant: AJINOMOTO CO., INC.Inventors: Takayuki Suzuki, Takayuki Hamada, Kunisuke Izawa
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Patent number: 6242635Abstract: A process for producing a 2-aralkyl-3-hydroxypropionic acid (or its ester), comprising the steps of: reacting a 3-hydroxy-2-methylene-3-arylpropionic acid ester, easily obtained by the reaction of an arylaldehyde with an acrylic acid ester, with an acid anhydride to form a 2-aralkylidene-3-acyloxypropionic acid ester; subjecting the same to hydrolysis or alcoholysis; and reducing the resulting 2-aralkylidene-3-hydroxypropionic acid or its ester. The reduction step may be conducted in the presence of a base.Type: GrantFiled: September 18, 1998Date of Patent: June 5, 2001Assignee: Ajinomoto Co., Inc.Inventors: Takayuki Suzuki, Takayuki Hamada, Kunisuke Izawa
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Patent number: 6239305Abstract: Optically active N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester useful as an enkephalin inhibitory agent or ACE inhibitory agent can be produced at low cost in an industrial manner, by a method comprising subjecting optically active 2-hydroxymethyl-3-phenylpropionic acid and glycine benzyl ester to condensation to subsequently convert the hydroxyl group into an elimination group, and substituting the elimination group with an acetylthio group.Type: GrantFiled: December 7, 1999Date of Patent: May 29, 2001Assignee: Ajinomoto Co., Inc.Inventors: Takayuki Suzuki, Takayuki Hamada, Kunisuki Izawa