Abstract: The first commercial material data and the second commercial material data to be displayed are commercial material data of a combination in which a similarity of content is highest, and a similarity of the brand design is highest among a plurality of combinations obtained from the plurality of generated commercial material data and the plurality of generated commercial material data.

Abstract: An information processing apparatus includes: an acquisition unit that acquires information of a color gamut reproducible by a printing unit that prints the commercial material; a generation unit that generates a plurality of commercial material data based on the accepted contents, the accepted designation of the impression, and the accepted condition of the commercial material; and a display unit that displays a commercial material image based on the generated plurality of commercial material data. The commercial material image is an image represented by data specified based on the accepted designation of the impression from a plurality of data generated from the plurality of commercial material data based on the acquired information of the color gamut.

Abstract: An optical connection structure including first optical fibers, second optical fibers, a first optical connector, and a second optical connector is disclosed. The first optical connector is configured such that each of first distal end portions of the first optical fibers protrudes from a first front end surface to the outside when the first optical connector and the second optical connector are connected to each other. Each of the first distal end portions is inserted into a corresponding second fiber hole of the second optical connector. The second optical connector is configured such that each of second distal end portions of the second optical fibers is moved rearward inside second fiber holes due to each of the first distal end portions respectively inserted into the second fiber holes. The first optical fibers and the second optical fibers are optically coupled to each other inside the second fiber holes.

Abstract: There are provided a light guide, an electron ray detector, and a charged particle device that can improve light guiding efficiency of light generated in response to incidence of a detection ray. The electron ray detector includes: a light guide member extending in one direction; a first fluorescent substance layer provided on one end portion side of the light guide member and generating primary fluorescent light in response to incidence of a detection ray; a second fluorescent substance layer extending from one end to the other end of the light guide member and generating secondary fluorescent light in response to incidence of the primary fluorescent light; and a detection unit provided on the other end portion side of the light guide member and optically coupled to the light guide member.

Abstract: An information processing apparatus receives, from a user, a designation of a target impression of a poster to be generated, receives, from a user, a designation of a target quality of the poster to be generated, and generates one or more pieces of poster data based on at least the target impression. The information processing apparatus calculates an evaluation value based on first information indicating a difference between the target impression and a degree of impression of each of the one or more pieces of poster data and second information indicating a difference between the target quality and a quality of each of the one or more pieces of poster data, and selects, from the one or more pieces of poster data, a poster for which the evaluation value has an evaluation higher than a predetermined evaluation.

Abstract: Provided are a print head and a method of manufacturing a print head which can reduce the number of parts and simplify the manufacturing process. A method includes: preparing first and second lid members as a lid member, the first lid member including a supply port through which an accommodation chamber can be supplied with a liquid, the second lid member not including the supply port; manufacturing a first print head by joining the first lid member to a housing, the first print head configured to eject the liquid from ejection ports with the accommodation chamber supplied with the liquid through the supply port; and manufacturing a second print head by joining the second lid member to the housing, the second print head being detachably attachable to a printing apparatus and configured to eject the liquid from the ejection ports without the accommodation chamber supplied with the liquid.

Abstract: The preventive or therapeutic agent for benign adult familial myoclonus epilepsy (BAFME) of the present invention contains an antisense oligonucleotide containing at least one of the base sequences of SEQ ID NOS: 1 to 4. Among the antisense oligonucleotides, oligonucleotide consisting of at least one of the base sequences of SEQ ID NOS: 1 to 4 may contain at least one RNase H inactive type nucleotide analog. The RNase H inactive type nucleotide analog may be ?-D-oxy-L-LNA, ?-D-ENA, R type cEt, 2?-OMe-nucleotide analog, and/or MOE-nucleotide analog.

Abstract: An information processing method includes: Step 1 of detecting a first SNP which is a mutation of an Alzheimer's disease-associated gene in a genomic DNA sample derived from a subject; and Step 2 of determining whether or not the subject will develop Alzheimer's disease from the first SNP using a machine learning model trained on a plurality of training datasets labeled with information on the onset of Alzheimer's disease for a second SNP, which is a mutation of the Alzheimer's disease-associated gene detected in a genomic DNA sample derived from a patient who has developed Alzheimer's disease.

Abstract: A positive electrode of a lithium secondary battery includes a sheet-like positive electrode current collector having conductivity, and a positive electrode active material plate that is a plate-like ceramic sintered compact joined to the positive electrode current collector via a conductive joint layer. The positive electrode active material plate includes at least one active material plate element. This at least one active material plate element is joined to the positive electrode current collector. A main surface of the active material plate element that opposes the positive electrode current collector includes a joint region in which the conductive joint layer exists between the positive electrode current collector and the active material plate element and a non-joint region in which the conductive joint layer does not exist between the positive electrode current collector and the active material plate element. The non joint region is arranged around the joint region.

Abstract: Disclosed is a switching valve having a small contact resistance when a valve body moves along a seating surface of a housing. In a switching valve which includes a valve body, coming into contact with a seating surface of a housing having a plurality of ports and selectively communicating at least two ports of the plurality of ports, and applies a fluid pressure to a back surface of the valve body, the switching valve includes a biasing member configured for biasing the valve body in a direction in which the valve body is moved away from the seating surface of the housing.

Abstract: The present invention provides novel antisense oligonucleotide pharmaceutical compositions having higher RNA aggregate-removing activity than conventional pharmaceutical compositions. The pharmaceutical composition of the present invention contains an oligonucleotide having any base sequence of a repeated sequence in which cytosine-adenine-guanine trinucleotides are repeated 5 to 13 times, from the 5? end to the 3? end, and the oligonucleotide has a mixmer structure containing at least two types of RNase H inactive nucleotide analogs. The present invention provides the pharmaceutical composition of the present invention used for the treatment of some symptoms of myotonic dystrophy type 1 disease.

Abstract: A cultured spherical body that is capable of easily performing quantitative analysis of a region containing brain neurons, useful as a supply source of neurons for transplantation, and can be used suitably for drug discovery screening for neurological diseases and compound evaluation systems is obtained. Provided are a cultured spherical body including a first cell layer containing neural stem cells and/or neural progenitor cells and a second cell layer containing brain neurons, wherein the first cell layer is present in the superficial portion of the cultured spherical body, and a method for producing the cultured spherical body.

Abstract: A resin composition for a medical device to be subjected to gas low-temperature sterilization includes a resin and an ion exchanger.

Abstract: An ultrasound endoscope includes: an ultrasound transducer including a piezoelectric element that includes a plurality of grooves with a groove filling material filled in the plurality of grooves, the groove filling material including the following (1) to (3): (1) an epoxy resin; (2) at least one filler selected from the group consisting of diamond, aluminum oxide, silicon oxide, silicon carbide, boron carbide, iron oxide (III), chromium oxide (III), and cubic boron nitride; and (3) an aliphatic diol diglycidyl ether.

Abstract: Provided is a valve with high pressure resistance. In a valve which is axially driven by a drive source to move a valve body to contact and separate from a valve seat in a valve chamber to control a fluid, a diaphragm has a center axially sandwiched by the valve body and a rod of the drive source and partitions the valve chamber and the drive source in a sealed state.

Abstract: The present invention derives from the unexpected finding that necroptosis is a novel biomarker and target for therapy in patients with liver failure such as acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). RIPK1, MLKL or RIPK3 can be detected and quantified in serum or plasma, and used as a biomarker for outcome in ACLF and other diseases involving aberrant necroptosis. By antagonising RIPK1, MLKL or RIPK3 many of the unwanted consequences or symptoms of acute-on-chronic liver failure (ACLF) may be reduced. The present invention utilises these findings to identify and provide antagonists of RIPK1, MLKL and RIPK3 that may be used in the treatment or prevention of ACLF. The present invention utilises these findings to identify and provide antagonists of RIPK1, MLKL or RIPK3 that may be used in the treatment or prevention of aberrant necroptosis in the kidney, brain, liver or other organ of the body.

Abstract: An acoustic lens contains a base material composed of a diorganopolysiloxane or a silicone rubber compound utilizing a diorganopolysiloxane as a main component, and plate-like inorganic compound particles dispersed in the base material.

Abstract: The present invention provides a prophylactic and/or therapeutic agent for Alzheimer's disease containing a compound represented by the formula (I) or the formula (II) or a salt thereof.

Abstract: An expansion valve includes: a main body portion having a valve chamber and a valve seat; a case fixed to the main body portion; and a screw shaft that is driven by driving force of rotation obtained by reducing a rotational movement of a rotor due to the excitation of an excitation portion by a speed reduction mechanism to move a valve body forward and backward. A bellows configured to seal a gap between the inside of the case and the valve chamber is arranged in the valve chamber to be externally fitted onto the valve body, and the rotation of the valve body relative to the main body portion is restricted by a rotation restrictor.

Abstract: An information processing device includes: an acquirer configured to acquire images obtained by imaging cells differentiated from pluripotent stem cells derived from a subject; and a predictor configured to input the images acquired by the acquirer to a model trained on data in which information indicating at least a neurodegenerative disease is associated with the image obtained by imaging the cells of the neurodegenerative disease differentiated from the pluripotent stem cells, and predict an onset of the neurodegenerative disease of the subject or effects of drugs on the neurodegenerative disease, based on output results of the model to which the images were input.