Patents by Inventor Takayuki Ohwaki
Takayuki Ohwaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8263123Abstract: The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.Type: GrantFiled: July 16, 2007Date of Patent: September 11, 2012Assignee: Eisai R&D Management Co., Ltd.Inventors: Yutaka Morita, Masanobu Yasui, Takayuki Ohwaki, Yuki Tsushima
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Patent number: 7727548Abstract: The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.Type: GrantFiled: March 1, 2001Date of Patent: June 1, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Yutaka Morita, Masanobu Yasui, Takayuki Ohwaki, Yuki Tsushima
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Publication number: 20100015221Abstract: The present invention provides an orally rapid disintegrating tablet preparation that contains a high dose of a fat-soluble active ingredient, that exhibits excellent disintegration characteristics in the oral cavity, and that can be produced by a dry tabletting method. The present invention also provides a method of producing an orally rapid disintegrating tablet preparation. The present invention discloses an orally rapid disintegrating tablet preparation that is obtained by tabletting a uniform mixture prepared by mixing saccharide alcohol, crystalline cellulose, and a lubricant with a granule that has been produced by the adsorption of a fat-soluble active ingredient on a porous material.Type: ApplicationFiled: December 20, 2006Publication date: January 21, 2010Applicant: Eisai R&D Management Co.Ltd.Inventors: Norishige Takami, Shinsuke Nagira, Yasushi Okada, Noriko Okada, Takayuki Ohwaki, Reiko Nishijima
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Publication number: 20100009003Abstract: The present invention provides a pharmaceutical preparation to be dispersed before administration which has an adequate viscosity and a suitable flowability even when dispersed in a small amount of water and can be easily administered through an NG tube is provided. Specifically, the pharmaceutical preparation to be dispersed before administration contains active granules containing a pharmaceutically active substance having an average particle diameter of 5 mm or less and a thickening agent, and can be administered through an NG tube by dispersing in water before administration.Type: ApplicationFiled: September 17, 2009Publication date: January 14, 2010Inventors: Koji UKAI, Yasuyuki Asai, Yoshiteru Kato, Takayuki Ohwaki, Shigeru Aoki, Yasuhiro Zaima, Takehiro Yamaguchi
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Publication number: 20080014262Abstract: The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.Type: ApplicationFiled: July 16, 2007Publication date: January 17, 2008Inventors: Yutaka MORITA, Masanobu Yasui, Takayuki Ohwaki, Yuki Tsushima
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Publication number: 20040202715Abstract: The present invention provides an intraoral quickly disintegrating tablet containing a phosphodiesterase inhibitor having an effect of improving the erectile dysfunction and a method for manufacturing the tablet. The present invention also provides an intraoral quickly disintegrating tablet containing a slightly soluble pharmaceutical agent having an improved solubility and a method for manufacturing the tablet. That is, it is an intraoral quickly disintegrating tablet containing a cyclic GMP phosphodiesterase inhibitor and a saccharide, and a method for manufacturing the tablet.Type: ApplicationFiled: April 29, 2004Publication date: October 14, 2004Applicant: EISAI CO., LTD.Inventors: Hisao Furitsu, Akira Kato, Takayuki Ohwaki, Masanobu Yasui
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Patent number: 6743443Abstract: The present invention provides an intraoral quickly disintegrating tablet containing a phosphodiesterase inhibitor having an effect of improving the erectile dysfunction and a method for manufacturing the tablet. The present invention also provides an intraoral quickly disintegrating tablet containing a slightly soluble pharmaceutical agent having an improved solubility and a method for manufacturing the tablet. That is, it is an intraoral quickly disintegrating tablet containing a cyclic GMP phosphodiesterase inhibitor and a saccharide, and a method for manufacturing the tablet.Type: GrantFiled: April 5, 2001Date of Patent: June 1, 2004Assignee: Eisai Co., Ltd.Inventors: Hisao Furitsu, Akira Kato, Takayuki Ohwaki, Masanobu Yasui
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Publication number: 20030086967Abstract: The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.Type: ApplicationFiled: August 13, 2002Publication date: May 8, 2003Inventors: Yutaka Morita, Masanobu Yasui, Takayuki Ohwaki, Yuki Tsushima
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Patent number: 6227836Abstract: A method and an apparatus for manufacturing tablets of moist powder which is produced by adding an additive agent such as an excipient or a binder to medical ingredients, further adding a solvent such as water, ethanol or the like, and kneading the mixture.Type: GrantFiled: February 9, 2000Date of Patent: May 8, 2001Assignee: Sankyo Seisakusho Co & Eisai Co., Ltd.Inventors: Heizaburo Kato, Yuki Tsushima, Takayuki Ohwaki, Masaharu Nakajima, Yutaka Morita
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Patent number: 6074586Abstract: A method and an apparatus for manufacturing tablets of moist powder which is produced by adding an additive agent such as an excipient or a binder to medical ingredients, further adding a solvent such as water, ethanol or the like, and kneading the mixture.Type: GrantFiled: April 17, 1997Date of Patent: June 13, 2000Assignee: Sankyo Seisakusho & Eisai Co., Ltd.Inventors: Heizaburo Kato, Yuki Tsushima, Takayuki Ohwaki, Masaharu Nakajima, Yutaka Morita
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Patent number: 5672364Abstract: A method and an apparatus for manufacturing tablets of moist powder which is produced by adding an additive agent such as an excipient or a binder to medical ingredients, further adding a solvent such as water, ethanol or the like, and kneading the mixture.Type: GrantFiled: June 26, 1995Date of Patent: September 30, 1997Assignee: Sankyo Seisakusho Co. & Eisai Co., Ltd.Inventors: Heizaburo Kato, Yuki Tsushima, Takayuki Ohwaki, Masaharu Nakajima, Yutaka Morita
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Patent number: 5603880Abstract: It is an object of the present invention to realize a method and an apparatus for efficiently mass-producing tablets of high mechanical strength, accuracy and quality which are so excellent in solubility and collapsibility that they can be easily taken by persons of advanced ages and infants. By using a turn table and endless belt means to which a number of dies are connected, a part of which turn table contacts with the endless belt means, the turn table and the endless belt means being adapted to relatively move with respect to each other, receptacles are formed by pressing plastic polymer film in mold cavities of the dies. Moist powder supplied from a hopper into filling holes of the turn table is pressurizingly filled in the receptacles by means of a filling and pressurizing device in the region where the turn table is laid above the endless belt means.Type: GrantFiled: June 26, 1995Date of Patent: February 18, 1997Assignee: Sankyo Seisakusho Co.Inventors: Heizaburo Kato, Yuki Tsushima, Takayuki Ohwaki, Masaharu Nakajima, Yutaka Morita
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Patent number: 4827062Abstract: A composition containing ubidecarenone, a glycerol mono-fatty acid ester and/or a propylene glycol mono-fatty acid ester, and a liquid oil. Oral administration of the composition provides a promoted absorption of ubidecarenone which is used for improving a coronary function.Type: GrantFiled: March 25, 1986Date of Patent: May 2, 1989Assignee: Eisai Co., Ltd.Inventors: Yasuharu Saeki, Takeshi Watanabe, Takayuki Ohwaki, Masahiro Kawahara, Yasuo Miyake
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Patent number: 4598070Abstract: An inclusion compound composed of tripamide and cyclodextrin markedly improves the solubility of tripamide which is effective for treatment of essential hypertension.Type: GrantFiled: July 18, 1984Date of Patent: July 1, 1986Assignee: Eisai Co., Ltd.Inventors: Takayuki Ohwaki, Shigeru Sakashita, Masahiro Kawahara, Aishin Shinoda, Yasuo Miyake
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Patent number: 4532881Abstract: This invention provides a process for sealing a body and a cap of a capsule which comprises successively dipping a gelatin hard capsule containing drugs one by one in a mixed solvent of water and ethanol whose volume ratio to water is 50-55%, thereafter taking said capsule out of this solvent and drying each capsule separately.Type: GrantFiled: July 16, 1984Date of Patent: August 6, 1985Assignee: Eisai Co., Ltd.Inventors: Shigeru Sakashita, Takeshi Nakagawa, Takayuki Ohwaki, Yasuo Miyake
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Patent number: 4510168Abstract: This invention provides a process for sealing a body and a cap of a capsule which comprises successively dipping a gelatin hard capsule containing drugs one by one in a mixed solvent of water and ethanol whose volume ratio to water is 50-55%, thereafter taking said capsule out of this solvent and drying each capsule separately.Type: GrantFiled: March 15, 1984Date of Patent: April 9, 1985Assignee: Eisai Co., Ltd.Inventors: Shigeru Sakashita, Takeshi Nakagawa, Takayuki Ohwaki, Yasuo Miyake