Abstract: The present invention provides a method for selecting a cancer patient for whom a combination therapy with a retinoid and a cancer treatment agent is effective, which comprises a step of selecting a cancer patient having a malignant tumor with the infiltration of cancer-associated fibroblasts in the stroma. In addition, the present invention provides a medicament which comprises a cancer patient having a malignant tumor with the infiltration of cancer-associated fibroblasts in the stroma is a subject and is administered in combination of a retinoid and a cancer therapeutic agent.

Abstract: A magnetic recording medium having a nonmagnetic substrate, and a soft magnetic layer and a ferromagnetic layer having a thickness of 5 to 150 nm formed in this order on the nonmagnetic substrate, in which, the ferromagnetic layer contains a spherical, ellipsoidal or plate-form ferromagnetic powder and a binder, and has an axis of easy magnetization substantially in a perpendicular direction, and the soft magnetic layer contains a spherical or ellipsoidal magnetite soft magnetic powder having a particle size of 30 nm or less, a rate of variation in particle size of 20% or less and a saturation magnetization of 10 to 60 Am2/kg, and a binder.

Abstract: An object of the present invention is to provide a pulsed-release preparation that achieves pulsed-release by coating the exterior of a core that contains a physiologically active substance and a disintegrant, with a controlled-release coating that contains a water-insoluble polymer and an enteric polymer, or a water-insoluble polymer and a water-soluble polymer, wherein a satisfactory pulsed-release can be achieved without increasing the amount of disintegrant in the core, in particular even in the low-water environment in the lower part of the digestive tract. The present invention provides a pulsed-release preparation comprising: 1) a core containing a physiologically active substance and a disintegrant; 2) an enteric coating that covers the core; and 3) a controlled-release coating that covers the enteric coating applied on the core and that contains a water-insoluble polymer and an enteric polymer or water-soluble polymer.

Abstract: A magnetic recording medium comprising a nonmagnetic substrate, and a soft magnetic layer and a ferromagnetic layer formed in this order on the nonmagnetic layer, in which the ferromagnetic layer has a thickness of from 3 to 150 nm, contains spherical, ellipsoidal or plate-form ferromagnetic particles and a binder, and has an axis of easy magnetization substantially in the vertical direction, and the soft magnetic layer contains spherical or ellipsoidal Fe—Co-containing soft magnetic particles having a saturation magnetization of from 170 to 220 Am2/kg, and a binder.