Abstract: A user breeds a virtual life form by practicing good sleep habits and stays motivated toward practicing good sleep habits while enjoying breeding the virtual life form. A game server manages progress of a breeding game of a virtual life form, the game server including circuitry configured to acquire sleep data that at least includes a sleep pattern indicating a bedtime and a wake-up time of a user; store the acquired sleep data as a sleep history; and update the breeding game based on the sleep pattern in the sleep history.

Abstract: An object is to provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. A game server that manages progress of a breeding game of a virtual life form can provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. The game server includes circuitry configured to acquire a wake-up time of a user; and a update the breeding game in accordance with the acquired wake-up time.

Abstract: An object is to provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. A game server that manages progress of a breeding game of a virtual life form can provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. The game server includes circuitry configured to acquire a wake-up time of a user; and a update the breeding game in accordance with the acquired wake-up time.

Abstract: An object is to provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. A game server that manages progress of a breeding game of a virtual life form can provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. The game server includes circuitry configured to acquire a wake-up time of a user; and a update the breeding game in accordance with the acquired wake-up time.

Abstract: An object is to provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. A game server that manages progress of a breeding game of a virtual life form can provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. The game server includes circuitry configured to acquire a wake-up time of a user; and a update the breeding game in accordance with the acquired wake-up time.

Abstract: A user breeds a virtual life form by practicing good sleep habits and stays motivated toward practicing good sleep habits while enjoying breeding the virtual life form. A game server manages progress of a breeding game of a virtual life form, the game server including circuitry configured to acquire sleep data that at least includes a sleep pattern indicating a bedtime and a wake-up time of a user; store the acquired sleep data as a sleep history; and update the breeding game based on the sleep pattern in the sleep history.

Abstract: A user breeds a virtual life form by practicing good sleep habits and stays motivated toward practicing good sleep habits while enjoying breeding the virtual life form. A game server manages progress of a breeding game of a virtual life form, the game server including circuitry configured to acquire sleep data that at least includes a sleep pattern indicating a bedtime and a wake-up time of a user; store the acquired sleep data as a sleep history; and update the breeding game based on the sleep pattern in the sleep history.

Abstract: The present invention provides a genetic modification non-human organism in which an expression level of Cas9 is high and a plurality of different genes or a plurality of different locations in the same gene can be edited at the same time with high efficiency. The genetic modification non-human organism of the present invention includes a nuclear genome having at least 3 copies of genes that code for Cas9 (CRISPR-associated 9). Egg cells of the present invention are derived from the genetic modification non-human organism having the nuclear genome into which at least 3 copies of genes that code for the Cas9 are introduced. Fertilized eggs of the present invention are obtained by fertilizing the egg cells and sperm derived from the same species of the organism. A method for modifying target genes of the present invention includes a step of introducing a guide RNA into cells derived from the genetic modification non-human organism, the egg cells, or the fertilized eggs.

Abstract: In a friction pad assembly for a disc brake, a plurality of lining assemblies supported on a guide plate are pressed to a disc rotor. The lining assembly includes a friction material and a back plate portion. A plate fitting portion of the lining assembly is inserted and equipped to a guide hole portion, and braking torque is transmitted from the plate fitting portion to the guide plate. A plurality of link plates applying pressing force from a torque receiving plate to the lining assembly are provided between the torque receiving plate and the back plate portion adhered to the guide plate. A damping layer sandwiched between inner surfaces of the torque receiving plate is provided on back surface sides of the link plates.

Abstract: A light emitting type capsule treatment tool for irradiating light with a specific wavelength required for photoimmunotherapy, includes a power receiving coil, a magnetic member, a light emitting member and a capsule. The power receiving coil is formed by winding a conductive wire and configured to receive electric power supplied from an external transmission antenna via a magnetic flux. The magnetic member is placed on an inner circumference of the power receiving coil. The light emitting member is configured to be supplied with electric power from the power receiving coil and to emit the light with the specific wavelength. The capsule houses the power receiving coil, the magnetic member and the light emitting member.

Abstract: A user breeds a virtual life form by practicing good sleep habits and stays motivated toward practicing good sleep habits while enjoying breeding the virtual life form. A game server manages progress of a breeding game of a virtual life form, the game server including circuitry configured to acquire sleep data that at least includes a sleep pattern indicating a bedtime and a wake-up time of a user; store the acquired sleep data as a sleep history; and update the breeding game based on the sleep pattern in the sleep history.

Abstract: An object is to provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. A game server that manages progress of a breeding game of a virtual life form can provide a user with motivation to enjoy waking up in the morning and guide the user to sufficient awakening by generating a breeding event in a breeding game of a virtual life form when the user wakes up in the morning. The game server includes circuitry configured to acquire a wake-up time of a user; and a update the breeding game in accordance with the acquired wake-up time.

Abstract: A friction pad assembly for a disc brake is provided. A lining assembly includes a friction material which is pressed against a disc rotor during braking and a back plate which is fixed to a back surface of the friction material, and the back plate includes a plate fitting part swingably fitted to a guide hole provided in a guide plate. The plate fitting part is fitted into the guide hole such that a braking torque acting when the friction material is pressed against the disc rotor is transmitted from the plate fitting part to the guide plate. A rotation regulator regulating a rotation of the lining assembly is integrally formed on a torque receiving plate fixed to the guide plate.

Abstract: A light emitting type capsule treatment tool for irradiating light with a specific wavelength required for photoimmunotherapy, includes a power receiving coil, a magnetic member, a light emitting member and a capsule. The power receiving coil is formed by winding a conductive wire and configured to receive electric power supplied from an external transmission antenna via a magnetic flux. The magnetic member is placed on an inner circumference of the power receiving coil. The light emitting member is configured to be supplied with electric power from the power receiving coil and to emit the light with the specific wavelength. The capsule houses the power receiving coil, the magnetic member and the light emitting member.

Abstract: In a friction pad assembly for a disc brake, a plurality of lining assemblies supported on a guide plate are pressed to a disc rotor. The lining assembly includes a friction material and a back plate portion. A plate fitting portion of the lining assembly is inserted and equipped to a guide hole portion, and braking torque is transmitted from the plate fitting portion to the guide plate. A plurality of link plates applying pressing force from a torque receiving plate to the lining assembly are provided between the torque receiving plate and the back plate portion adhered to the guide plate. A damping layer sandwiched between inner surfaces of the torque receiving plate is provided on back surface sides of the link plates.

Abstract: The present invention provides a genetically modified non-human organism in which an expression level of Cas9 is high and a plurality of different genes or different locations in the same gene can be edited at the same time with high efficiency. The genetically modified non-human organism includes a nuclear genome having at least 3 copies of genes that code for Cas9 (CRISPR-associated 9). Egg cells of the present invention are derived from the genetically modified non-human organism having the nuclear genome into which at least 3 copies of genes that code for the Cas9 are introduced. Fertilized eggs of the present invention are obtained by fertilizing the egg cells and sperm derived from the same species of the organism. A method for modifying target genes includes a step of introducing a guide RNA into cells derived from the genetically modified non-human organism, the egg cells, or the fertilized eggs.

Abstract: A disk brake includes a floating caliper, a pair of brake pads, a driving piston and a caliper return mechanism. The floating caliper includes a base portion which is slidably supported via a guide pin to a support and a pair of pressing arms which extend from the base portion to pinch a disk rotor. The brake pads are provided in tip portions of the pressing arms so as to face side surfaces of the disk rotor. The driving piston is provided on one of the pressing arms so as to drive one of the brake pads toward one of the side surfaces. The caliper return mechanism is arranged in at least one of both end portions of the guide pin on a side opposite to the driving piston side so as to elastically bias the base portion to the side opposite to the driving piston side.

Abstract: A disk brake includes a floating caliper, a pair of brake pads, a driving piston and a caliper return mechanism. The floating caliper includes a base portion which is slidably supported via a guide pin to a support and a pair of pressing arms which extend from the base portion to pinch a disk rotor. The brake pads are provided in tip portions of the pressing arms so as to face side surfaces of the disk rotor. The driving piston is provided on one of the pressing arms so as to drive one of the brake pads toward one of the side surfaces. The caliper return mechanism is arranged in at least one of both end portions of the guide pin on a side opposite to the driving piston side so as to elastically bias the base portion to the side opposite to the driving piston side.

Abstract: It is intended to provide an angiogenic agent which contains, as the active ingredient, at least one substance selected from the group consisting of adrenomedullin, a substance inhibiting the activity of adrenomedullin degrading enzyme, an adrenomedullin receptor activity-modifying protein, a calcitonin receptor-like receptor and an adrenomedullin receptor.

Abstract: The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others. The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1.