Abstract: [Task] There is provided a practical method for producing a lipidic peptide compound, the method enabling to mass-produce the lipidic peptide compound inexpensively with no need of complicated operations. [Solution] There is provided a method to mix a non-polar solvent solution of an ester compound represented by formula (1) with a non-polar organic solvent containing an ?-amino acid compound and a base represented by formula (2) so as to produce a lipidic peptide compound or a pharmacologically acceptable salt thereof represented by formula (3).

Abstract: A method for producing a lipid peptide compound represented by formula (3) or a pharmaceutically usable salt thereof, the method comprising: a reaction step of reacting an ester compound of the following Formula (1) with an ?-amino acid compound of the following Formula (2) and a base in a solvent containing a non-polar organic solvent; an extraction step of adding an organic acid to a solution containing a salt of a lipidic peptide prepared through the reaction step and being of the following Formula (3) to thereby neutralize the solution, adding water and an alcohol to the neutralized solution, and subjecting the resultant mixture to phase separation, thereby removing the non-polar organic solvent; and a separation step of removing the lipidic peptide compound of Formula (3) from the solution prepared through the extraction step to the outside of the system.

Abstract: Provided are a composition for forming a coating film, a coating film and a substrate having the coating film, which have excellent compatibility with biological substances, as well as a method for producing the same. A composition for forming a coating film having the ability to inhibit adhesion of biological substances, the composition comprising a copolymer and a solvent, wherein the copolymer is obtained by subjecting a monomer mixture to polymerization, wherein the monomer mixture comprises compounds represented by the following formulae (1), (2), and (3): wherein R1 to R6, n, and m are as defined in the Description and Claims, wherein the compound represented by the formula (3) above is contained in a predetermined amount in the monomer mixture, a coating film obtained from the composition, and a substrate having the coating film as well as a method for producing the same.

Abstract: The invention provides a method for producing a copolymer-containing varnish using a monomer having a specific unsaturated bond which does not cause the problem of gelation, a method for producing a composition, a method for producing a coating film, preferably compatible with biomaterials. The method for producing a copolymer-containing varnish comprises copolymerizing a monomer mixture containing compounds of formulas (1) and (2): wherein R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 6 carbon atoms, n represents an integer of 1 to 30, R11 represents a hydrogen atom or a methyl group, and A1 represents a monovalent organic group having a cationic property, in a solvent for polymerization, in the presence of a radical polymerization initiator, wherein % by mass of the compound of formula (1) in a phosphorus-containing compound contained in the monomer mixture is 70% by mass or more.

Abstract: The invention provides a container for storing a biomaterial in which adhesion of a minute amount of a biomarker(s) contained in the biomaterial to the surface of the container for storage can be suppressed, and sample loss is reduced, while enabling analysis with accuracy and highly precision. In particular, the container for storing a biomaterial for reducing sample loss of a biomarker(s) contained in the biomaterial has a coating containing a copolymer which contains a recurring unit which contains a group represented by the following formula (a), a recurring unit which contains a group represented by the following formula (b), and optionally a recurring unit which contains a group represented by the following formula (c), on at least a part of the surface of the container: (wherein, Ua1, Ua2, Ub1, Ub2 and Ub3, An? and Rc are as defined herein).

Abstract: A composition that can more readily form a coating film exhibiting excellent moisture-retaining property. A coating film-forming composition including at least one lipidic peptide compound composed of a low-molecular-weight lipidic peptide or a pharmaceutically usable salt thereof. The lipidic peptide compound may preferably be a compound prepared by bonding of a peptide moiety having an amino acid repeating structure to a lipidic moiety having a C9-23 aliphatic group.

Abstract: There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material comprising a lipid peptide-type gelator that is formed of at least one selected from compound of the following formula (1): where R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group which optionally has a C1-2 branched chain; R3 is a —(CH2)n—X group; n is a number from 1 to 4; and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring group or a 6-membered ring group, or a condensed ring group that contains a 5-membered ring and a 6-membered ring, optionally containing 1 to 3 nitrogen atoms, and the similar compounds or pharmaceutically usable salts thereof; water; and an additive including either an organic acid or an organic acid salt.

Abstract: There is provided a practical method for preparing lipopeptide compounds, which method is capable of inexpensive mass production without requiring complicated operations. The lipopeptide compound of formula (3): is produced by reacting an ester compound of formula (1): with an ?-amino acid compound of formula (2): in the presence of a base and within a solvent containing a nonpolar organic solvent.

Abstract: There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material comprising a lipid peptide-type gelator that is formed of at least one selected from compound of the following formula (1): where R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group which optionally has a C1-2 branched chain; R3 is a —(CH2)n—X group; n is a number from 1 to 4; and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring group or a 6-membered ring group, or a condensed ring group that contains a 5-membered ring and a 6-membered ring, optionally containing 1 to 3 nitrogen atoms, and the similar compounds or pharmaceutically usable salts thereof; water; and an additive including either an organic acid or an organic acid salt.

Abstract: There is provided a practical method for preparing lipopeptide compounds, which method is capable of inexpensive mass production without requiring complicated operations. The lipopeptide compound of formula (3): is produced by reacting an ester compound of formula (1): with an ?-amino acid compound of formula (2): in the presence of a base and within a solvent containing a nonpolar organic solvent.