Patents by Inventor Takefumi Doi

Takefumi Doi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING SUBSTANCE WITH MODIFIED CARBON ALLOTROPE SURFACE, METHOD FOR PRODUCING SUBSTANCE WITH CARBON ALLOTROPE SURFACE INTO WHICH FUNCTIONAL GROUP IS INTRODUCED, METHOD FOR PRODUCING GRID FOR CRYO-ELECTRON MICROSCOPY, ORGANIC SUBSTANCE, AND GRID FOR CRYO-ELECTRON MICROSCOPY
    Publication number: 20220204346
    Abstract: The present invention provides a method for producing a substance with a modified carbon allotrope surface that can suppress or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance in a structural analysis by cryo-electron microscopy. A method for producing a substance with a modified carbon allotrope surface of the present invention includes: the step of surface-treating by reacting a carbon allotrope surface with a halogen oxide radical, wherein the carbon allotrope surface is modified by the surface-treating.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 30, 2022
    Inventors: Tsuyoshi INOUE, Haruyasu ASAHARA, Kei OHKUBO, Kenji IWASAKI, Naoyuki MIYAZAKI, Mika HIROSE, Atsushi NAKAGAWA, Junichi TAKAGI, Takefumi DOI, Hiroaki ADACHI
  • Anti-CLDN-5 antibody, and drug containing said antibody
    Patent number: 11053313
    Abstract: An object of the present invention is to provide a novel molecule which has high specificity to CLDN-5 and recognizes an extracellular domain of CLDN-5. The object is achieved by an antibody which specifically recognizes a three-dimensional structure or a primary structure of an extracellular domain of a Claudin-5 protein.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: July 6, 2021
    Assignees: OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY, FUJIFILM WAKO PURE CHEMICAL CORPORATION
    Inventors: Masuo Kondoh, Kiyohito Yagi, Takefumi Doi, Yoshiaki Okada, Yosuke Hashimoto, Tatsuya Sawasaki, Hiroyuki Takeda, Kohki Endo, Maki Tamura
  • Claudin 5 antibody, and medicine containing said antibody
    Patent number: 10882906
    Abstract: Provided is a novel technique for controlling the blood-brain barrier. An antibody whose epitope is a region within an extracellular domain of Claudin 5 protein.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: January 5, 2021
    Assignee: OSAKA UNIVERSITY
    Inventors: Yoshiaki Okada, Masuo Kondoh, Yosuke Hashimoto, Keisuke Shirakura, Takefumi Doi, Kiyohito Yagi, Hiroyuki Takeda, Tatsuya Sawasaki
  • Claudin 5 ANTIBODY, AND MEDICINE CONTAINING SAID ANTIBODY
    Publication number: 20200223915
    Abstract: Provided is a novel technique for controlling the blood-brain barrier. An antibody whose epitope is a region within an extracellular domain of Claudin 5 protein.
    Type: Application
    Filed: December 4, 2017
    Publication date: July 16, 2020
    Applicant: OSAKA UNIVERSITY
    Inventors: Yoshiaki OKADA, Masuo KONDOH, Yosuke HASHIMOTO, Keisuke SHIRAKURA, Takefumi DOI, Kiyohito YAGI, Hiroyuki TAKEDA, Tatsuya SAWASAKI
  • ANTI-CLDN-5 ANTIBODY, AND DRUG CONTAINING SAID ANTIBODY
    Publication number: 20200148765
    Abstract: An object of the present invention is to provide a novel molecule which has high specificity to CLDN-5 and recognizes an extracellular domain of CLDN-5. The object is achieved by an antibody which specifically recognizes a three-dimensional structure or a primary structure of an extracellular domain of a Claudin-5 protein.
    Type: Application
    Filed: April 26, 2018
    Publication date: May 14, 2020
    Applicants: OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY, FUJIFILM Wako Pure Chemical Corporation
    Inventors: Masuo KONDOH, Kiyohito YAGI, Takefumi DOI, Yoshiaki OKADA, Yosuke HASHIMOTO, Tatsuya SAWASAKI, Hiroyuki TAKEDA, Kohki ENDO, Maki TAMURA
  • Peptide derivatives having binding activity to modified low density lipoprotein
    Patent number: 5747451
    Abstract: Peptide derivatives represented by the formula (I): ##STR1## which can specifically bind to modified LDL in competition with scavenger receptors on macrophages and are useful in diagnosing, preventing and treating circulatory diseases caused by accumulation of modified LDL in macrophages.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: May 5, 1998
    Assignee: Protein Engineering Research Institute
    Inventors: Toshiki Tanaka, Takefumi Doi, Haruki Nakamura, Takeshi Imanishi, Tatsuhiko Kodama