Patents by Inventor Takehiko Fujino
Takehiko Fujino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250011347Abstract: A compound represented by formula (I), its racemic form, or their salt, wherein X represents an oxygen atom, a nitrogen atom or a sulfur atom; R1 represents an unsaturated aliphatic hydrocarbon group; R2 represents a saturated or unsaturated aliphatic hydrocarbon group; and R3 represents choline, ethanolamine, inositol or serine.Type: ApplicationFiled: August 22, 2022Publication date: January 9, 2025Applicants: Institute of Rheological Function of Food Co., Ltd., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Takehiko FUJINO, Shiro MAWATARI, Tatsuo OKAUCHI, Takuya HISAMITSU, Shamim NIWASE, Masanori HONSHO, Kinichi NAKASHIMA, Hideyuki NAKASHIMA
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Patent number: 12111307Abstract: A method for assessing aging of erythrocytes that includes preparing an erythrocyte suspension from a blood sample; allowing the erythrocyte suspension to pass through a first filter, separating aged erythrocytes that do not pass through the first filter, and non-aged erythrocytes that pass through the first filter, and to calculate a deformability of erythrocytes, allowing the separated non-aged erythrocyte suspension to pass through a second filter having micropores which diameter is smaller than the first filter, separating mild aged erythrocytes that do not pass through the second filter and juvenile erythrocytes that pass through the second filter, and to calculate a deformability of the non-aged erythrocytes; and assessing aging of erythrocytes, using the deformability of erythrocyte and the deformability of non-aged erythrocyte.Type: GrantFiled: June 10, 2019Date of Patent: October 8, 2024Assignee: INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOODInventors: Takehiko Fujino, Shiro Mawatari, Tsunemichi Kawa, Tetsuji Koyama, Toyoharu Yamashita
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Patent number: 12060379Abstract: A compound presented by the general formula (1), its racemic form, or their salt thereof: wherein in general formula (1), X represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R1 represents R1a—Y—R1b, wherein R1a and R1b independently represent a saturated or unsaturated aliphatic hydrocarbon group, aromatic group, heterocyclic group, or a combination thereof, and Y represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R2 independently represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.Type: GrantFiled: April 18, 2019Date of Patent: August 13, 2024Assignee: Institute of Rheological Functions of FoodInventors: Takehiko Fujino, Shiro Mawatari, Toyoharu Yamashita, Mitsuru Kitamura, Tatsuo Okauchi, Shamim Hossain
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Publication number: 20240156845Abstract: A composition for ameliorating periodontal tissue containing plasmalogen extracted from animal tissues such as shellfish, sea squirts and birds.Type: ApplicationFiled: February 22, 2022Publication date: May 16, 2024Applicant: Institute of Rheological Function of Food Co., Ltd.Inventors: Takayoshi KAWAZOE, Kengo IWASAKI, Ryuhei KANDA, Takehiko FUJINO, Shiro MAWATARI, Shamim NIWASE
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Publication number: 20230293415Abstract: A composition for ameliorating skin condition having a collagen production promoting effect, a composition for ameliorating skin resilience, a composition for ameliorating skin wrinkles, a composition for ameliorating skin sagging, and a composition for promoting collagen production.Type: ApplicationFiled: June 28, 2021Publication date: September 21, 2023Applicant: Institute of Rheological Function of Food Co., Ltd.Inventors: Takehiko FUJINO, Shiro MAWATARI, Masanori HONSHO
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Publication number: 20230248628Abstract: A composition having hair growth and/hair restoration effect that includes plasmalogen extracted from tissues of animal such as shellfish, sea squirt, and birds, and that can be used as external preparation or oral preparation.Type: ApplicationFiled: June 28, 2021Publication date: August 10, 2023Applicant: Institute of Rheological Function of Food Co., Ltd.Inventors: Takehiko FUJINO, Shiro MAWATARI, Masanori HONSHO
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Publication number: 20230158050Abstract: It is a composition for enhancing immune function, or a composition for activating natural killer cells, comprising plasmalogen.Type: ApplicationFiled: April 27, 2021Publication date: May 25, 2023Applicant: Institute of Rheological Function of Food Co., Ltd.Inventors: Takehiko FUJINO, Shiro MAWATARI, Shamim NIWASE, Minoru FUJINO, Hiromi NYUZUKI
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Patent number: 11491170Abstract: A method for manufacturing a functional material that contains plasmalogen, the method including treating an animal tissue containing plasmalogen with protease, and extracting the animal tissue treated with protease with an extraction liquid containing ethanol.Type: GrantFiled: April 18, 2019Date of Patent: November 8, 2022Assignee: INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOODInventors: Takehiko Fujino, Shiro Mawatari
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Publication number: 20210361681Abstract: A method for manufacturing a functional material that contains plasmalogen, the method including treating an animal tissue containing plasmalogen with protease, and extracting the animal tissue treated with protease with an extraction liquid containing ethanol.Type: ApplicationFiled: April 18, 2019Publication date: November 25, 2021Applicant: INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOODInventors: Takehiko FUJINO, Shiro MAWATARI
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Publication number: 20210255165Abstract: A method for assessing aging of erythrocytes that includes preparing an erythrocyte suspension from a blood sample; a allowing the erythrocyte suspension to pass through a first filter, separating aged erythrocytes that do not pass through the first filter, and non-aged erythrocytes that pass through the first filter, and to calculate a deformability of erythrocytes, allowing the separated non-aged erythrocyte suspension to pass through a second filter having micropores which diameter is smaller than the first filter, separating mild aged erythrocytes that do not pass through the second filter and juvenile erythrocytes that pass through the second filter, and to calculate a deformability of the non-aged erythrocytes; and assessing aging of erythrocytes, using the deformability of erythrocyte and the deformability of non-aged erythrocyte.Type: ApplicationFiled: June 10, 2019Publication date: August 19, 2021Applicant: INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOODInventors: Takehiko FUJINO, Shiro MAWATARI, Tsunemichi KAWA, Tetsuji KOYAMA, Toyoharu YAMASHITA
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Publication number: 20210238208Abstract: A compound presented by the following Chemical Formula 1, a racemic form, or a salt thereof: wherein, X represents an oxygen atom, a nitrogen atom, a sulfur atom, or a carbon atom, R1 represents R1a—Y—R1b (wherein R1a and R1b each independently represent a saturated or unsaturated aliphatic hydrocarbon group, an aromatic group, a heterocyclic group, or a combination thereof, and Y represents an oxygen atom, a nitrogen atom, a sulfur atom, or a carbon atom), R2 represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.Type: ApplicationFiled: April 18, 2019Publication date: August 5, 2021Applicant: Institute of Rheological Functions of FoodInventors: Takehiko FUJINO, Shiro MAWATARI, Toyoharu YAMASHITA, Mitsuru KITAMURA, Tatsuo OKAUCHI, Shamim HOSSAIN
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Patent number: 11066432Abstract: [PROBLEM TO BE SOLVED] It enables any superior ether phospholipids to the conventional ones and a method for producing the same in an easy manner on a massive scale, in light of effects of treating and improving brain diseases such as Alzheimer's disease, Parkinson disease, depression and schizophrenia, metabolic diseases such as diabetes, various infectious diseases, and immune disorders. [SOLUTION] Ether phospholipids are obtained from bivalve tissues such as clams and corbicula by extraction processing. The ether phospholipids exhibit significantly superior effects of the above as compared to the conventional ether phospholipids derived from chicken tissues.Type: GrantFiled: May 13, 2015Date of Patent: July 20, 2021Inventors: Takehiko Fujino, Shiro Mawatari
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Patent number: 10653708Abstract: The present invention relates to uses of ether phospholipids in treating and preventing various diseases, including, but not limited to, neurodegenerative or brain diseases such as Alzheimer's disease, cognitive impairment, brain fatigue, Parkinson disease, depression, anxiety disorder, insomnia and schizophrenia; metabolic syndrome such as diabetes and obesity; various infectious diseases such as viral diseases; diseases related to inflammation; heart diseases, and immune disorders. Preferably, the ether phospholipids are derived from extracting bivalves, which provides superior efficacies in treating and preventing the diseases.Type: GrantFiled: June 16, 2017Date of Patent: May 19, 2020Assignee: Institute of Rheological Functions of FoodInventors: Takehiko Fujino, Shiro Mawatari
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Publication number: 20190242915Abstract: The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.Type: ApplicationFiled: April 16, 2019Publication date: August 8, 2019Applicant: Institute of Rheological Functions of FoodInventors: Takehiko Fujino, Shiro Mawatari
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Patent number: 10324100Abstract: The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.Type: GrantFiled: April 4, 2017Date of Patent: June 18, 2019Assignee: Institute of Rheological Functions of FoodInventors: Takehiko Fujino, Shiro Mawatari
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Publication number: 20190167799Abstract: To provide an ether-type glycerophospholipid-containing composition that has excellent heat stability and also has oxidation stability and storage stability. An ether-type glycerophospholipid-containing composition that comprises not more than 20 mass % of an ether-type glycerophospholipid and not less than 80 mass % of a cyclodextrin. Owing to this constitution, the ether-type glycerophospholipid is clathrated in the cyclodextrin. Thus, the ether-type glycerophospholipid-containing composition has highly excellent heat stability as well as temporal stability such as oxidation stability and storage stability even in a powdery form.Type: ApplicationFiled: April 27, 2016Publication date: June 6, 2019Applicant: B&S CORPORATION:KKInventors: Yasuhiro SASUGA, Masaru FUKUI, Takehiko FUJINO, Shiro MAWATARI
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Publication number: 20180360854Abstract: The present invention relates to uses of ether phospholipids in treating and preventing various diseases, including, but not limited to, neurodegenerative or brain diseases such as Alzheimer's disease, cognitive impairment, brain fatigue, Parkinson disease, depression, anxiety disorder, insomnia and schizophrenia; metabolic syndrome such as diabetes and obesity; various infectious diseases such as viral diseases; diseases related to inflammation; heart diseases, and immune disorders. Preferably, the ether phospholipids are derived from extracting bivalves, which provides superior efficacies in treating and preventing the diseases.Type: ApplicationFiled: June 16, 2017Publication date: December 20, 2018Applicant: Institute of Rheological Functions of FoodInventors: Takehiko Fujino, Shiro Mawatari
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Publication number: 20180327433Abstract: [PROBLEM TO BE SOLVED] It enables any superior ether phospholipids to the conventional ones and a method for producing the same in an easy manner on a massive scale, in light of effects of treating and improving brain diseases such as Alzheimer's disease, Parkinson disease, depression and schizophrenia, metabolic diseases such as diabetes, various infectious diseases, and immune disorders. [SOLUTION] Ether phospholipids are obtained from bivalve tissues such as clams and corbicula by extraction processing. The ether phospholipids exhibit significantly superior effects of the above as compared to the conventional ether phospholipids derived from chicken tissues.Type: ApplicationFiled: May 13, 2015Publication date: November 15, 2018Applicant: Institute of Rheological Functions of FoodInventors: Takehiko FUJINO, Shiro MAWATARI
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Publication number: 20180284143Abstract: The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.Type: ApplicationFiled: April 4, 2017Publication date: October 4, 2018Applicant: Institute of Rheological Functions of FoodInventors: Takehiko Fujino, Shiro Mawatari
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Patent number: 9974727Abstract: Provided is a novel hair growth and hair restoration material having excellent efficacy in hair growth and hair restoration for both men and women, even when the components thereof are at ultra-dilute concentrations; the hair growth and hair restoration material being characterized in containing a sterol glucopyranoside, preferably a cholesteryl glucopyranoside, represented by general formula (I). (In the formula, Z represents a sterol residue from which the hydroxyl group attached to the 3-position of a cyclopentanohydrophenanthrene ring has been removed.Type: GrantFiled: March 9, 2016Date of Patent: May 22, 2018Assignee: Institute of Rheological Function of Food Co., Ltd.Inventors: Takehiko Fujino, Osami Nada, Yoshitaka Nadachi, Gunki Funatsu