Abstract: A nano-fluidic device includes: a first substrate that has a nanoscale groove on one surface; and a second substrate that is integrally provided with the first substrate by bonding one surface of the second substrate to the one surface of the first substrate and forms a nanochannel with the groove of the first substrate, in which either the first substrate or the second substrate includes at least a thin portion in a part of a position overlapping the nanochannel in plan view, and the thin portion is deformed by pressing to open and close the nanochannel.

Abstract: A first proton-donating layer (20a) is a layer having a proton-donative functional group on the surface, for example, a silicon oxide layer. A second proton-donating layer (20b) is also a layer having a proton-donative functional group on the surface, for example, a silicon oxide layer. Negative surface charges are formed on the main surface section of a first base (10a) and the main surface section of a second base (10b), and these negative charges increased the proton conductivity in an aqueous solution fed to a nano channel. Although, in the aqueous solution, proton migration through hopping between water molecules contributes to its diffusion, the negative charges formed on the main surfaces of the bases (10a, 10b) attract protons in the aqueous solution, and the conduction of protons is efficiently achieved in “high-speed transfer regions” formed in the vicinity of the proton-donating layers (20a, 20b).

Abstract: The present disclosure provides an interface device that is capable of introducing a sample that has been ionized into a mass spectrometer with high efficiency. An ice droplet generating section forms ice droplets from a liquid sample that has been supplied from a sample supply section. Further, the ice droplet generating section successively introduces the formed ice droplets into an ionization section. The ionization section ionizes the sample that has been made into ice droplets, and conveys these ionized droplets into a mass spectrometer.

Abstract: A functional device (and a functional device manufacturing method) includes a first substrate in which a groove is formed in one surface, a second substrate which is integrally disposed by bonding one surface of the second substrate to the one surface of the first substrate, and forms a flow path together with the groove of the first substrate, at least one modification object of a capture body which captures a target substance supplied into the flow path, an electrode which imparts an electrical or a chemical action to the target substance, and a catalyst, in which the modification object is disposed by being modified on a part of an inner surface of the flow path, a bonding portion between the one surface of the first substrate and the one surface of the second substrate is formed by bonding fluorine to silica.

Abstract: A nano-fluidic device includes: a first substrate that has a nanoscale groove on one surface; and a second substrate that is integrally provided with the first substrate by bonding one surface of the second substrate to the one surface of the first substrate and forms a nanochannel with the groove of the first substrate, in which either the first substrate or the second substrate includes at least a thin portion in a part of a position overlapping the nanochannel in plan view, and the thin portion is deformed by pressing to open and close the nanochannel.

Abstract: A first proton-donating layer (20a) is a layer having a proton-donative functional group on the surface, for example, a silicon oxide layer. A second proton-donating layer (20b) is also a layer having a proton-donative functional group on the surface, for example, a silicon oxide layer. Negative surface charges are formed on the main surface section of a first base (10a) and the main surface section of a second base (10b), and these negative charges increased the proton conductivity in an aqueous solution fed to a nano channel. Although, in the aqueous solution, proton migration through hopping between water molecules contributes to its diffusion, the negative charges formed on the main surfaces of the bases (10a, 10b) attract protons in the aqueous solution, and the conduction of protons is efficiently achieved in “high-speed transfer regions” formed in the vicinity of the proton-donating layers (20a, 20b).

Abstract: A functional device (and a functional device manufacturing method) includes a first substrate in which a groove is formed in one surface, a second substrate which is integrally disposed by bonding one surface of the second substrate to the one surface of the first substrate, and forms a flow path together with the groove of the first substrate, at least one modification object of a capture body which captures a target substance supplied into the flow path, an electrode which imparts an electrical or a chemical action to the target substance, and a catalyst, in which the modification object is disposed by being modified on a part of an inner surface of the flow path, a bonding portion between the one surface of the first substrate and the one surface of the second substrate is formed by bonding fluorine to silica.

Abstract: Provided is a microchip capable of integrating liquid evaporation as an operation on the microchip. In the microchip 10 having a gas flow path 13 inside, liquid is dispersed by capillary action and pooled in a pool portion 12 at a bottom of the gas flow path 13, and at least a part of the liquid pooled in the pool portion 12 is evaporated. As the capillary action is used, the liquid can be dispersed and pooled in the pool portion 12 at the bottom of the gas flow path 13 inside the microchip 10. Besides, the liquid pooled in the pool portion 12 remains in the pool portion by a surface tension even if gas is made to flow in the gas flow path 13 or the gas flow path is evacuated for evaporation. This enables highly efficient evaporation inside the microchip 10.

Abstract: An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.

Abstract: A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 ?m to 100 ?m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.

Abstract: An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.

Abstract: A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 ?m to 100 ?m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.

Abstract: A new technical means is provided that can be produced and prepared at low cost, and in which the generation of stagnation in the flow of a liquid sample can be suppressed, microbeads can be smoothly and simply injected, filled and transported and the generation of dust can be also suppressed and a new extracting method for nucleic acid using the new technical means is provided. A microchip has a microchannel (3) formed by groove parts (11, 21) provided in connecting surfaces of upper and lower substrates (1, 2). In the microchannel (3), a gap part (31) in which the section of the channel is reduced is provided in a central part upward and downward, rightward and leftward, or upward and downward and rightward and leftward the section thereof, and microbeads are checked.

Abstract: A microchip, which is used in a diagnostic system using a microfluid system, has a flow path capable of greatly improving the reaction efficiency and realizing a stable measurement with high reproducibility. The microchip has two substrates with at least a flow path 12 formed at the interface between the two substrates, the flow path 12 having a reaction area 14 and a detection area 15 downstream of the reaction area 14, and the flow path 12 at the detection area 15 having a depth which is deeper than the flow path 12 in the reaction area 14.

Abstract: A slide valve apparatus includes a first member having a first fluid channel for allowing a fluid to flow therethrough, a second member sliding along the first member and having a second fluid channel formed in a manner to communicate with the first fluid channel, and a first elastic membrane formed in the sliding surface along which the second member and the first member slide relative to each other and having a first communicating hole communicating with the first fluid channel. In manufacturing the slide valve apparatus, a gas is spurted from the open edge of the first fluid channel in at least a stage between the start up of the step of forming the elastic membrane and the end of the step of baking the elastic membrane so as to form in the elastic membrane the communicating hole communicating with the first fluid channel.

Abstract: Provided is a microchip capable of integrating liquid evaporation as an operation on the microchip. In the microchip 10 having a gas flow path 13 inside, liquid is dispersed by capillary action and pooled in a pool portion 12 at a bottom of the gas flow path 13, and at least a part of the liquid pooled in the pool portion 12 is evaporated. As the capillary action is used, the liquid can be dispersed and pooled in the pool portion 12 at the bottom of the gas flow path 13 inside the microchip 10. Besides, the liquid pooled in the pool portion 12 remains in the pool portion by a surface tension even if gas is made to flow in the gas flow path 13 or the gas flow path is evacuated for evaporation. This enables highly efficient evaporation inside the microchip 10.

Abstract: A micromixer 100 includes a mixing chamber 1 in which a liquid plug A6 is introduced, and a fluid channel section 2 in which a liquid plug B7 is flowed. The fluid channel section 2 is connected to the mixing chamber 1. The micromixer 100 causes the liquid plug B7 that flows inside the fluid channel section 2 to accelerate in a direction towards the mixing chamber 1 and to flow into the mixing chamber 1, so that the liquid plug B7 comes in contact with the liquid plug A6. This allows efficient stirring and mixing of the liquid plug A6 and liquid plug B7.

Abstract: For enlarging the application range of samples capable of being treated, decreasing the amount of samples used, preventing deterioration of samples by a change with the passage of time and preventing mixing of samples by diffusion, a micro fluidics system according to the present invention comprises a sample server which stores plural samples and which has sample efflux portions, a microchip for feeding samples to a treating portion through plural sample introducing portions communicating with the sample efflux portions and further through a microchannel, allowing the samples to be subjected to a predetermined treatment, and a sample feeder for feeding the samples stored in the sample server to the sample introducing portions through the sample efflux portions.

Abstract: An objective of the present invention is to provide a circular dichroism thermal lens microscope apparatus capable of identifying and quantifying optically active samples in ultra-trace amounts, and which has a higher sensitivity than conventional apparatuses. The objective is achieved by a circular dichroism thermal lens microscope apparatus which beams excitation light and detection light into an optical microscope, where the detection light enters a thermal lens formed by irradiating a sample with the excitation light, and a substance in a sample is detected by determining the diffusion of the detection light by the thermal lens, and where the excitation light is modulated by a phase-modulation element, so as to identify or quantify an optical isomer.

Abstract: A method of catalytic reaction uses a micro-reactor (1) with a metal catalyst (5) or a metal complex catalyst (5) as a solid phase supported on the inner wall (4c) of a channel (4), a solution (7) dissolving a reactant as a liquid phase and hydrogen (9) as a gas phase are flown through the channel (4) in pipe flow state, and the reaction of the solution (7) and the gas (9) accelerated by the metal catalyst (5) or the metal complex catalyst (5) is conducted by three phase catalytic reaction of solid-liquid-gas phases. The metal catalyst (5) or the metal complex catalyst (5) is incorporated in a polymer, and hydrogenation reaction by three phase catalytic reductive reaction of a substance to be reduced can be conducted in short time at good yield. For hydrogenation reaction of unsaturated organics, the rate of reaction and yield are high when palladium catalyst is used, and carbonylation reaction can be conducted if carbon monoxide is used instead of hydrogen.