Patents by Inventor Takehiko Ohkawa
Takehiko Ohkawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7776897Abstract: There is provided a compound which can be used for therapy of diseases in which 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) participates, in particular diabetes, insulin resistance. It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11?-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.Type: GrantFiled: September 14, 2005Date of Patent: August 17, 2010Assignee: Astellas Pharma Inc.Inventors: Takeshi Murakami, Tomoaki Kawano, Ryota Shiraki, Hirofumi Ishii, Seiji Yoshimura, Takehiko Ohkawa, Mitsuru Hosaka, Hiroki Fukudome, Yutaka Inoki
-
Publication number: 20070259854Abstract: [Problem] There is provided a compound which can be used for therapy of diseases in which 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) participates, in particular diabetes, insulin resistance. [Means for Solution] It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11?-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.Type: ApplicationFiled: September 14, 2005Publication date: November 8, 2007Applicant: ASTELLAS PHARMA INC.Inventors: Takeshi Murakami, Tomoaki Kawano, Ryota Shiraki, Hirofumi Ishii, Seiji Yoshimura, Takehiko Ohkawa, Mitsuru Hosaka, Hiroki Fukudome, Yutaka Inoki
-
Patent number: 7186731Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is ?CH2, ?CHF or ?CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.Type: GrantFiled: October 29, 2004Date of Patent: March 6, 2007Assignee: Astellas Pharma Inc.Inventors: Ichiro Shima, Akio Kuroda, Takehiko Ohkawa, Toshio Kurosaki, Yuki Sawada, Aiko Wada
-
Patent number: 7129243Abstract: The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof.Type: GrantFiled: December 18, 2001Date of Patent: October 31, 2006Assignee: Astellas Pharma Inc.Inventors: Ichiro Shima, Takehiko Ohkawa, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
-
Publication number: 20050137224Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is ?CH2, ?CHF or ?CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.]having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.Type: ApplicationFiled: October 29, 2004Publication date: June 23, 2005Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.Inventors: Ichiro Shima, Akio Kuroda, Takehiko Ohkawa, Toshio Kurosaki, Yuki Sawada, Aiko Wada
-
Patent number: 6825200Abstract: The present invention a compound represented by the formula (I): where the structural variables R1-R6 are defined herein.Type: GrantFiled: May 6, 2002Date of Patent: November 30, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ichiro Shima, Takehiko Ohkawa, Kazuhiko Ohne, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
-
Publication number: 20040157891Abstract: A compound of the formula (I): 1Type: ApplicationFiled: January 16, 2004Publication date: August 12, 2004Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.Inventors: Hirofumi Yamamoto, Junya Ishida, Daisuke Tanabe, Shigeki Satoh, Yuki Sawada, Takehiko Ohkawa, Kenichiro Imamura, Katsuya Nakamura
-
Publication number: 20040097425Abstract: The present invention relates to a compound of the formula (I)wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.Type: ApplicationFiled: December 23, 2003Publication date: May 20, 2004Inventors: Ichiro Shima, Takehiko Ohkawa, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
-
Patent number: 6495542Abstract: A compound of formula (I): wherein A is an optionally substituted heterocyclic group, R is a lower alkoxy; Z is C═O or CH2; and B is benzazapinyl, which may be optionally substituted, or a salt thereof, that possesses vasopressin antagonistic activity and is useful as a vasopressin antagonist.Type: GrantFiled: October 16, 2000Date of Patent: December 17, 2002Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Yuki Sawada, Kazuhiko Osoda, Teruo Oku
-
Publication number: 20020132809Abstract: 1Type: ApplicationFiled: February 25, 2002Publication date: September 19, 2002Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Teruo Oku, Ichiro Shima, Takehiko Ohkawa, Kazuhiko Ohne, Tatsuya Zenko, Kousei Yoshihara, Hiroyuki Setoi
-
Patent number: 6316482Abstract: This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I): wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower alkyl, etc., R3 is hydrogen, etc., A is NH, etc., E is etc., X is —CH═CH—, —CH═N—, or S, and Y is a condensed heterocyclic group, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.Type: GrantFiled: July 11, 2000Date of Patent: November 13, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Hitoshi Sawada, Yuki Sawada, Teruo Oku
-
Patent number: 6211242Abstract: This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by the general formula (I): wherein R1 is aryl optionally substituted with lower alkyl, etc., R2 is lower alkyl, etc., R3 is hydrogen, etc., R4 is aryl, etc., X is CH or N, and Y is CH or N, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.Type: GrantFiled: January 30, 1998Date of Patent: April 3, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Keiji Hemmi, Hirokazu Tanaka
-
Patent number: 6207693Abstract: This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I): wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower alkyl, etc., R3 is hydrogen, etc., A is NH, etc., E is etc., X is —CH═CH—, —CH═N—, or S, and Y is a condensed heterocyclic group, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.Type: GrantFiled: June 2, 1999Date of Patent: March 27, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Hitoshi Sawada, Yuki Sawada, Teruo Oku
-
Patent number: 6054457Abstract: This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R.sup.1 is aryl optionally substituted with lower alkoxy, etc., R.sup.2 is lower alkyl, etc.,R.sup.3 is hydrogen, etc.,R.sup.4 is lower alkoxy, etc.,R.sup.5 is hydrogen, etc.,A is NH, etc.,E is ##STR2## etc., X is --CH.dbd.CH--, --CH.dbd.N--, or S, andY is CH or N,and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.Type: GrantFiled: December 9, 1997Date of Patent: April 25, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Hitoshi Sawada, Kentaro Sato, Hirokazu Tanaka
-
Patent number: 5789405Abstract: An oxaspiro ?2,5!octane derivative of the formula: ##STR1## useful in inhibiting angiogenesis in solid tumors.Type: GrantFiled: June 5, 1991Date of Patent: August 4, 1998Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Teruo Oku, Chiyoshi Kasahara, Takehiko Ohkawa, Masashi Hashimoto
-
Patent number: 5767293Abstract: Oxaspiro?2,5! octanes of the formula ##STR1## inhibit angiogenesis and are particularly suitable for the treatment of solid tumors. In preferred embodiments, R.sup.1 is a carbamoyl derivative, R.sup.2 is an alkoxy substituent and R.sup.3 is ##STR2## Pharmaceutical salts of these compounds, such as methyl, amonium and organic amine salts also exhibit desirable properties.Type: GrantFiled: August 5, 1994Date of Patent: June 16, 1998Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Teruo Oku, Chiyoshi Kasahara, Takehiko Ohkawa, Masashi Hashimoto
-
Patent number: 5521170Abstract: Compounds having the structure below ##STR1## and pharmaceutically acceptable salts thereof exhibit vasopressin antagonistic activity, vasodilating activity, hypotensive activity, activity for inhibiting saccharide release in the liver, activity for inhibiting growth of mesagium cells, water diuretic activity, platelet agglutination inhibitory activity, oxytocin antagonistic activity and the like, and are useful in treating or preventing hypertension, heart failure, renal insufficiency, edema, ascites, vasopressin parasecretion syndrome, hepatocirrhosis, hyponatremia, hypokalemia, diabetic or circulation disorder, oxytocin related diseases and the like.Type: GrantFiled: March 31, 1994Date of Patent: May 28, 1996Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Keiji Hemmi, Hirokazu Tanaka
-
Patent number: 4954496Abstract: The invention relates to a cyclohexane derivative, useful as an angiogenesis inhibitor, of the formula: ##STR1## wherein R.sup.1 is halomethyl; or arylthiomethyl which may have amino, lower alkoxy or acylamino,R.sup.2 is lower alkoxy,R.sup.3 is ##STR2## or ##STR3## and R.sup.4 is hydrogen, lower alkylcarbamoyl, lower alkylcarbamoyloxy(lower)alkylcarbamoyl, heterocyclic carbonyl or heterocyclic carbamoyl, or salt thereof.Type: GrantFiled: July 28, 1989Date of Patent: September 4, 1990Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Teruo Oku, Ciyoshi Kasahara, Takehiko Ohkawa, Masashi Hashimoto