Patents by Inventor Takehiko Shibata
Takehiko Shibata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050260631Abstract: An object of the present invention is to provide a nucleic acid amplification method for amplifying a desired nucleic acid while suppressing amplification of byproducts in a PCR reaction, a reagent kit used for nucleic acid amplification, a method of detecting single nucleotide polymorphism to detect single nucleotide polymorphism by utilizing that amplification of byproducts is suppressed in a PCR reaction, and a reagent kit used for detecting single nucleotide polymorphism. The method of amplifying nucleic acids by PCR is characterized by admixing in a reaction solution, a homologous recombinant protein which contains at least one of a RecA protein derived from Thermus thermophilus, and a modified RecA protein obtained by modification of the RecA protein and having a function similar to that of the RecA protein, and carrying out PCR.Type: ApplicationFiled: March 17, 2005Publication date: November 24, 2005Applicants: AISIN COSMOS R&D CO., LTD., RIKEN, KAZUSA DNA RESEARCH INSTITUTEInventors: Yasushi Shigemori, Takehiko Shibata, Tsutomu Mikawa, Michio Oishi, Osamu Ohara
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Publication number: 20030049818Abstract: A complex having homologous-pairing activity, produced by expressing a DNA encoding Xrcc2 and a DNA encoding Rad51D and recovering a complex of Xrcc2 and Rad51D; a vector comprising a DNA encoding Xrcc2 and a DNA encoding Rad51D; and a transformant having been transformed to enhance expressions of a DNA encoding Xrcc2 and a DNA encoding Rad51D.Type: ApplicationFiled: June 6, 2002Publication date: March 13, 2003Inventors: Hitoshi Kuruymizaka, Shigeyuki Yokoyama, Takehiko Shibata
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Patent number: 6528296Abstract: The present invention relates to a site-specific endonuclease which recognizes a specific nucleotide sequence, to a gene coding for the endonuclease, to a recombinant vector containing the gene, to a transformant containing the vector, and to a process for producing the endonuclease.Type: GrantFiled: August 20, 2001Date of Patent: March 4, 2003Assignee: Institute of Physical and Chemical ResearchInventors: Nobuhiro Morishima, Hikaru Mizumura, Takehiko Shibata
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Publication number: 20020164738Abstract: The present invention provides a protein which inhibits the activation of caspase-12 and uses of the protein.Type: ApplicationFiled: February 16, 2001Publication date: November 7, 2002Inventors: Nobuhiro Morishima, Takehiko Shibata
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Publication number: 20020137110Abstract: The present invention provides the antibody that react with the cleavage product of vimentin, but not with intact vimentin.Type: ApplicationFiled: May 21, 2002Publication date: September 26, 2002Inventors: Nobuhiro Morishima, Keiko Nakanishi, Takehiko Shibata
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Patent number: 6417336Abstract: The present invention provides the antibody that react with the cleavage product of vimentin, but not with intact vimentin.Type: GrantFiled: July 5, 2000Date of Patent: July 9, 2002Assignee: RikenInventors: Nobuhiro Morishima, Keiko Nakanishi, Takehiko Shibata
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Patent number: 6280942Abstract: The present invention relates to a site-specific endonuclease which recognizes a specific nucleotide sequence, to a gene coding for the endonuclease, to a recombinant vector containing the gene, to a transformant containing the vector, and to a process for producing the endonuclease.Type: GrantFiled: May 20, 1999Date of Patent: August 28, 2001Assignee: Institute of Physical and Chemical ResearchInventors: Nobuhiro Morishima, Hikaru Mizumura, Takehiko Shibata
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Patent number: 5908747Abstract: A multi-step method of detecting a gene in a nuclear chromosome which is involved in mitochondrial recombination is disclosed. The method disclosed includes the steps: a) fusing enucleated .omega..sup.- mitochondrial donor cells expressing a first marker gene with nucleus-containing .omega..sup.+ mitochondrial recipient cells expressing a second marker gene different from the first marker gene to form fused cells wherein the fused cells have one type of mitochondria and b) selecting fused cells that are .omega..sup.+ and express the first and second marker genes to identify those enucleated .omega..sup.- mitochondrial donor cells with a reduced recombination frequency. The method includes the further steps of judging that the gene in a nuclear chromosome of the recipient cells involved in mitochondrial recombination is normal when the mitochondrial recombination frequency is high or that the gene is mutated when the recombination frequency is low.Type: GrantFiled: June 21, 1996Date of Patent: June 1, 1999Assignee: Institute of Physical and Chemical ResearchInventors: Takehiko Shibata, Feng Ling, Fusao Makishima
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Patent number: 5864407Abstract: An image processing system of the invention has a reader which reads out an image of an original, a page memory which stores image information of the original in the form of electric signals, a disk memory which stores part or all of the image information in the disk memory and also stores image processing information, an image processing section, a digitizer for the operator to input the image processing information, a CRT which displays input information or corrections in convesation language, a DMA controller, and a printer. The image processing system of the invention is capable of DMA transfer without the intermediacy of a CPU. Fewer addresses are required for readout of the image information from the memory, and high speed image processing is achieved.Type: GrantFiled: October 20, 1994Date of Patent: January 26, 1999Assignee: Canon Kabushiki KaishaInventors: Katsuichi Shimizu, Takehiko Shibata, Yoshikazu Yokomizo, Akira Suzuki, Koichi Murakami, Tadashi Yoshida, Masaharu Tsukada, Nao Nagashima, Ken Miyagi
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Patent number: 5289451Abstract: An optical information recording/reproducing apparatus for stably recording, reproducing, or erasing the information by a laser beam with respect to different kinds of optical disks is represented. This apparatus includes a processor to record, reproduce, or erase the information for an optical disk, a disk sort detector to detect the sort of optical disk, and a controller to control the processing parameters of the processor in response to an output signal from the disk sort detector. The disk sort detector reads the disk sort identifying information preliminarily recorded on the optical disk by the processor to detect the sort of disk. Or, this detector irradiates light onto labels having different reflection factors or transmission factors preliminarily provided on the optical disks by the processor and detects the reflected light amounts or transmitted light amounts from the labels, thereby detecting the sort of disk.Type: GrantFiled: September 30, 1992Date of Patent: February 22, 1994Assignee: Canon Kabushiki KaishaInventors: Takaaki Ashinuma, Shigeru Aoi, Makoto Shiho, Yasuo Suzuki, Takehiko Shibata, Masaharu Tsukada, Nobuhiro Kasama, Takayuki Aizawa
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Patent number: 5008760Abstract: An image processing system of the invention has a reader which reads out an image of an original, a page memory which stores image information of the original in the form of electric signals, a disk memory which stores part or all of the image information in the disk memory and also stores image processing information, an image processing section, a digitizer for the operator to input the image processing information, a CRT which displays input information or corrections in conversation language, a DMA controller, and a printer. The image processing system of the invention is capable of DMA transfer without the intermediacy of a CPU. Fewer addresses are required for readout of the image information from the memory, and high speed image processing is achieved.Type: GrantFiled: August 30, 1989Date of Patent: April 16, 1991Assignee: Canon Kabushiki KaishaInventors: Katsuichi Shimizu, Takehiko Shibata, Yoshikazu Yokomizo, Akira Suzuki, Koichi Murakami, Tadashi Yoshida, Masaharu Tsukada, Nao Nagashima, Ken Miyagi
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Patent number: 4918677Abstract: An apparatus for recording or reproducing information on or from a recording medium such as a disk which rotates at a constant angular velocity. This apparatus comprises: a system to record or reproduce the data on or from the disk; a circuit to designate the recording or reproduction address of the data on the disk; and a control circuit to control the data recording or reproducing rate for the disk. The control circuit makes the recording or reproducing rate constant for a predetermined data and changes the recording or reproducing rate for the other data in accordance with the recording or reproduction address. In this apparatus, by providing track groups in the header portions and data recording portions in the direction of radius of the disk, the clock rate can be easily changed and the recording density is increased and the access time is reduced.Type: GrantFiled: January 21, 1986Date of Patent: April 17, 1990Assignee: Canon Kabushiki KaishaInventors: Takaaki Ashinuma, Takehiko Shibata
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Patent number: 4811109Abstract: An image processing system of the invention has a reader which reads out an image of an original, a page memory which stores image information of the original in the form of electric signals, a disk memory which stores part or all of the image information in the disk memory and also stores image processing information, an image processing section, a digitizer for the operator to input the image processing information, a CRT which displays input information or corrections in conversation language, a DMA controller, and a printer. The image processing system of the invention is capable of DNA transfer without the intermediacy of a CPU. Fewer addresses are required for readout of the image information from the memory, and high speed image processing is achieved.Type: GrantFiled: June 18, 1986Date of Patent: March 7, 1989Assignee: Canon Kabushiki KaishaInventors: Katsuichi Shimizu, Takehiko Shibata, Yoshikazu Yokomizo, Akira Suzuki, Koichi Murakami, Tadashi Yoshida, Masaharu Tsukada, Nao Nagashima, Ken Miyagi
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Patent number: 4556915Abstract: This invention provides an image reproduction device having a horizontal coordinate memory, a vertical coordinate memory and a domain code memory which comprise respectively a RAM, horizontal and vertical counters, horizontal and vertical coordinate comparators, an addressable latch for the horizontal coordinate comparator and an addressable latch for the vertical coordinate comparator, gate circuits and an A/D converter. The image reproduction device prevents recording in black of a portion surrounding the original when the size of a recording medium is larger than that of the original, thus preventing poor appearance of the image reproduced on recording medium.Type: GrantFiled: July 31, 1984Date of Patent: December 3, 1985Assignee: Canon Kabushiki KaishaInventors: Takehiko Shibata, Yoshikazu Yokomizo
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Patent number: 4541044Abstract: An information transmitting apparatus having plural terminal units connected in a loop-shaped transmission channel, in which the signal transmission is maintained even in the event of a failure of power supply to a terminal unit, by effective use of back-up power supply according to the state of function of terminal units.Type: GrantFiled: August 30, 1984Date of Patent: September 10, 1985Assignee: Canon Kabushiki KaishaInventor: Takehiko Shibata
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Patent number: 4517606Abstract: A video signal processing apparatus for encoding video into binary signals employs dither coding. The apparatus comprises a device for setting a plural number of divided areas of an original image and a processing circuit for processing video signals corresponding to the respective divided areas using different dither patterns.Type: GrantFiled: September 21, 1984Date of Patent: May 14, 1985Assignee: Canon Kabushiki KaishaInventors: Yoshikazu Yokomizo, Takehiko Shibata, Katsuichi Shimizu, Ken Miyagi, Akira Suzuki, Tadashi Yoshida, Masaharu Tsukata, Koichi Murakami, Nao Nagashima
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Patent number: 4430432Abstract: A novel Endo-deoxyribonuclease A (Endo-DNase A) which has the substrate specificity of recognizing specific base sequence in double-stranded deoxyribonucleic acid (DNA) molecules and cleaving the strands at specified sites in the DNA to produce specific DNA fragments and, a process for the production of the Endo-DNase A by culturing a microorganism belonging to the genus Saccharomyces or Pichia.Type: GrantFiled: March 1, 1982Date of Patent: February 7, 1984Assignee: Rikagaku KenkyushoInventors: Tadahiko Ando, Takehiko Shibata, Hiroomi Watabe
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Patent number: 4267511Abstract: A surface potentiometer having a measuring electrode disposed at a predetermined distance from a surface to be measured and in which the electric field between the measuring electrode and the surface to be measured is intermittently shielded by a rotatable chopper to thereby induce an AC signal in the measuring electrode and the AC signal is clamped at a timing corresponding to the position of the chopper relative to the electrode to thereby accurately measure the potential of the surface to be measured.Type: GrantFiled: October 31, 1978Date of Patent: May 12, 1981Assignee: Canon Kabushiki KaishaInventors: Koji Suzuki, Takehiko Shibata
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Patent number: 4259446Abstract: Disclosed is a process for the preparation of deoxyribonucleases (DNases) which comprise culturing a novel transformant belonging to the genus Bacillus, collecting a cell-free extract from cells obtained during a period ranging from the late logarithmic growth phase to the initial stage of the stationary growth phase, and subjecting said cell-free extract to fractionation or separation to obtain two or more DNases each of which possessing different substrate specificity.Type: GrantFiled: July 19, 1979Date of Patent: March 31, 1981Assignee: Rikagaku KenkyushoInventors: Tadahiko Ando, Takehiko Shibata, Eiji Hayase, Shukuko Ikawa
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Patent number: 4161424Abstract: The present invention relates to novel enzymes which decompose nucleic acid and are endowed with a substrate specificity recognizing specific biological deoxyribonucleic acid and cleaving specific bonds thereof to produce fragments of deoxyribonucleic acid of specific sizes and which are obtained by culturing microorganisms belonging to genus Bacillus and purifying the cell free extract thereof by such treatment as streptomycin treatment, ammonium sulfate precipitation, ion exchange chromatography, gel filtration or combination of these processes.Type: GrantFiled: July 18, 1977Date of Patent: July 17, 1979Assignee: Rikagaku KenkyushoInventors: Tadahiko Ando, Takehiko Shibata, Shukuko Ikawa, Cholung Kim