Patents by Inventor Takehiko Yoshimitsu

Takehiko Yoshimitsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED CARDIOMETABOLIC DISEASES
    Publication number: 20220088015
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of age-related cardiometabolic diseases. The inventors identified osteopontin (OPN) as a critical mediator of adipose tissue remodeling and senescence in obesity and extends this observation to related co-morbidities such as cardiomyopathy. Said result raises the possibility that inhibition of OPN activity may be of value in the prevention of cardiometabolic disease, in particular metabolic cardiomyopathy for which no specific treatment is yet available. In particular, the present invention relates to a method of treating an age-related cardiometabolic disease in an elderly subject in need thereof comprising administering to the subject a therapeutically effective amount of an osteopontin (OPN) inhibitor.
    Type: Application
    Filed: September 1, 2021
    Publication date: March 24, 2022
    Inventors: Geneviève DERUMEAUX, Daigo SAWAKI, Gabor CZIBIK, Takehiko YOSHIMITSU
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED CARDIOMETABOLIC DISEASES
    Publication number: 20200330459
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of age-related cardiometabolic diseases. The inventors identified osteopontin (OPN) as a critical mediator of adipose tissue remodeling and senescence in obesity and extends this observation to related co-morbidities such as cardiomyopathy. Said result raises the possibility that inhibition of OPN activity may be of value in the prevention of cardiometabolic disease, in particular metabolic cardiomyopathy for which no specific treatment is yet available. In particular, the present invention relates to a method of treating an age-related cardiometabolic disease in an elderly subject in need thereof comprising administering to the subject a therapeutically effective amount of an osteopontin (OPN) inhibitor.
    Type: Application
    Filed: April 5, 2017
    Publication date: October 22, 2020
    Inventors: Geneviève DERUMEAUX, Daigo SAWAKI, Gabor CZIBIK, Takehiko YOSHIMITSU
  • Substituted imidazo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazines and oxazolo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazines for treating brain cancer
    Patent number: 9464093
    Abstract: This document relates to compounds and compositions useful for treating cancers, such as brain and nervous system cancers.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: October 11, 2016
    Assignees: Mayo Foundation for Medical Education and Research, Osaka University
    Inventors: Han W. Tun, Takehiko Yoshimitsu, Daisuke Shigeoka, Takuma Kamon, Zhimin Li, Yushi Qiu, Thomas R. Caulfield
  • Treating Brain Cancer using Agelastatin A (AA) and Analogues Thereof
    Publication number: 20150274742
    Abstract: This document relates to compounds and compositions useful for treating cancers, such as brain and nervous system cancers.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 1, 2015
    Inventors: Han W. Tun, Takehiko Yoshimitsu, Daisuke Shigeoka, Takuma Kamon, Zhimin Li, Yushi Qiu, Thomas R. Caulfield