Abstract: The present invention aims to provide a novel compound which has CGRP receptor antagonist activity and which is useful for the treatment of various diseases mediated by CGRP receptors. That is, the present invention relates to the pyrrolidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. In the formulae, W is ring, X is a carbon atom or the like, Y1 to Y4 are carbon atoms or the like, and R1 to R7 is alkyl or the like. The compounds of the present invention or a pharmaceutically acceptable salt thereof have an excellent CGRP receptor antagonist activity, and thus are useful as agents for the treatment of various diseases mediated by CGRP receptors.

Abstract: A circuit device includes a first pad and a second pad that are disposed in a first pad disposition region along a first side; a third pad and a fourth pad that are disposed in a second pad disposition region along a second side which faces the first side; and a first to fourth electrostatic protection circuits that are disposed in a circuit disposition region between the first pad disposition region and the second pad disposition region and are connected to the first to fourth pads.

Abstract: Provided is an alkaline water electrolyzer in which leakage of aqueous alkali solutions is prevented. The alkaline water electrolyzer 10 includes an anode chamber frame 11 defining an anode chamber 12; a cathode chamber frame 17 defining a cathode chamber 18; a porous diaphragm 16 disposed between the anode and cathode chamber frames 11 and 17 and partitioning the anode and cathode chambers 12 and 18; an anode gasket 15 disposed on the anode chamber frame 11; and a cathode gasket 21 disposed on the cathode chamber frame 17, wherein when the anode and cathode chamber frames 11 and 17 are fastened, the porous diaphragm 16 is held between the anode and cathode chamber frames 11 and 17 via the anode and cathode gaskets 15 and 21 and the anode and cathode gaskets 15 and 21 are in contact with each other around the peripheral edge of the porous diaphragm 16 by compressing the anode and cathode gaskets 15 and 21.

Abstract: Magnetic field strength of a converging lens is repeatedly and alternately changed between first strength and second strength. The information about a first aperture image in the case where the magnetic field strength is the first strength and the information about a second aperture image in the case where the magnetic field strength is the second strength are produced. A first movement instruction for the first and second aperture images is given based on the first information and the second information during repetitive changes of the magnetic field strength. Based on the first movement instruction, a first deflector is controlled. A second movement instruction for the first and second aperture images is given based on the first information and the second information during repetitive changes of the magnetic field strength. Based on the second movement instruction, a second deflector is controlled.

Abstract: A circuit device includes an oscillation circuit configured to cause a resonator to oscillate, a clock signal output circuit configured to output a clock signal based on an oscillation signal from the oscillation circuit, a temperature compensation circuit configured to perform temperature compensation on an oscillation frequency of the oscillation signal, a low-potential-side power supply pad to which low-potential-side electric power is supplied, a high-potential-side power supply pad to which high-potential-side electric power is supplied, and an inter-power-supply capacitor provided between a low-potential-side power supply line electrically continuous with the low-potential-side power supply pad and a high-potential-side power supply line electrically continuous with the high-potential-side power supply pad. The inter-power-supply capacitor is formed of at least two metal layers provided in a region where the temperature compensation circuit is disposed in a plan view.

Abstract: An oscillation circuit includes an amplification circuit that causes a resonator to oscillate, and a variable capacitance circuit whose capacitance value is controlled on the basis of a control voltage. The variable capacitance circuit includes a first variable capacitive element in which an inflection point voltage in a change characteristic of a capacitance value for the control voltage is a first voltage, and a second variable capacitive element in which an inflection point voltage in a change characteristic of a capacitance value for the control voltage is a second voltage which is different from the first voltage. A capacitance value of the first variable capacitive element when the control voltage is the first voltage is different from a capacitance value of the second variable capacitive element when the control voltage is the second voltage.

Abstract: Magnetic field strength of a converging lens is repeatedly and alternately changed between first strength and second strength. The information about a first aperture image in the case where the magnetic field strength is the first strength and the information about a second aperture image in the case where the magnetic field strength is the second strength are produced. A first movement instruction for the first and second aperture images is given based on the first information and the second information during repetitive changes of the magnetic field strength. Based on the first movement instruction, a first deflector is controlled. A second movement instruction for the first and second aperture images is given based on the first information and the second information during repetitive changes of the magnetic field strength. Based on the second movement instruction, a second deflector is controlled.

Abstract: With strength of an objective lens set to first strength, a first scanned image of a sample is produced. The strength of the objective lens is set to second strength. A rotation amount difference of a charged particle beam between the case where the strength is set to the first strength and the case where the strength is set to the second strength is specified. At the second strength, with a scanner controlled such that the rotation for canceling the rotation amount difference is supplied to the charged particle beam, a second scanned image of the sample is produced. Based on a relative positional relationship between the first and second scanned images, a deflector is controlled such that positions of the first and second scanned images coincide with each other.

Abstract: An object is to more accurately compare diagnosis indexes with each other, which are calculated from data obtained in different environments with a cardiac-function diagnostic medicine. A conversion function calculation unit acquires a first phantom Heart/Mediastinum ratio (H/M ratio) and a second phantom H/M ratio based on a phantom, the first phantom H/M ratio that is an H/M ratio of the phantom in the first imaging environment being acquired by performing, based on phantom data that is data of a first phantom image obtained by imaging the phantom in the first imaging environment and digital phantom data that is data of a digital phantom including a cardiac ROI and a mediastinum ROI, positioning of the digital phantom on the first phantom image, and by calculating based on the phantom data of the first phantom image to which the cardiac ROI and the mediastinum ROI are set; and obtains a conversion function based on the first phantom H/M ratio and the second phantom H/M ratio.

Abstract: An object is to more accurately compare diagnosis indexes with each other, which are calculated from data obtained in different environments with a cardiac-function diagnostic medicine. A conversion function calculation unit acquires a first phantom Heart/Mediastinum ratio (H/M ratio) and a second phantom H/M ratio based on a phantom, the first phantom H/M ratio that is an H/M ratio of the phantom in the first imaging environment being acquired by performing, based on phantom data that is data of a first phantom image obtained by imaging the phantom in the first imaging environment and digital phantom data that is data of a digital phantom including a cardiac ROI and a mediastinum ROI, positioning of the digital phantom on the first phantom image, and by calculating based on the phantom data of the first phantom image to which the cardiac ROI and the mediastinum ROI are set; and obtains a conversion function based on the first phantom H/M ratio and the second phantom H/M ratio.

Abstract: A luggage support hook is attached to a center tunnel immediately above a storage unit, which is provided at a rear portion of a leg shield of a saddle-type vehicle, in order to provide a degree of freedom in a manner of hooking a hanging strap of an article to be hung on the luggage support hook, and to retain luggage in a stable state during travel. The luggage support hook is formed in a substantially Y-shape, when viewed from a front side, by a base member attached to a recess portion, a plurality of first arms projecting radially from a rear end of the base member, and a second arm member projecting from a position of the rear end of the base member. The second arm member is different from the first arms.

Abstract: The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Abstract: The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Abstract: The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Abstract: A luggage support hook is attached to a center tunnel immediately above a storage unit, which is provided at a rear portion of a leg shield of a saddle-type vehicle, in order to provide a degree of freedom in a manner of hooking a hanging strap of an article to be hung on the luggage support hook, and to retain luggage in a stable state during travel. The luggage support hook is formed in a substantially Y-shape, when viewed from a front side, by a base member attached to a recess portion, a plurality of first arms projecting radially from a rear end of the base member, and a second arm member projecting from a position of the rear end of the base member. The second arm member is different from the first arms.

Abstract: The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Abstract: The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3, R4, R5 and R6 are each hydrogen, halogen, lower alkyl or lower alkoxy; R7 and R8 are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R9 is —C(O)—R10, -A1-C(O)—R10, —O-A2-C(O)—R10 or a tetrazol-5-yl group, which exhibit potent and selective ?3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Abstract: Crystals of a salt of 4?-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3-isopropyl-3?,5?-dimethylbiphenyl-4-carboxylic acid. The ? type, ? type and ? type crystals produced by treating hydrochloride of 4?-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3-isopropyl-3?,5?-dimethylbiphenyl-4-carboxylic acid with specified solvents, which can be discriminated by the characteristic diffraction peaks of powder X-ray diffractometry and the like.

Abstract: The present invention provides an industrial method for preparing aminoalcohol derivatives (I) having a biphenyl group, biphenyloxyacetaldehyde derivatives which are used therefore, preparing methods thereof, and intermediates used for the preparing method. The present invention also provides a preparing method including processes for preparing a 3-substituted biphenylcarboxylic acid derivative represented by the following general formula: by allowing a 3-fluorobiphenylcarboxylic acid derivative prepared from a 3-fluorobiphenylcarbonitrile derivative which can be prepared by allowing a 4-halophenol derivative to react with a 2-fluorobenzonitrile derivative which is substituted by a leaving group at 4-position to react with an organometallic reagent.