Patents by Inventor Takehiro Koshio

Takehiro Koshio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6'-deoxy-6'-halo-neplanocin A and its production
    Patent number: 5187174
    Abstract: A compound of the formula ##STR1## wherein A is adenine-9-yl and X is halogen, Preferably iodine, or a pharmaceutically acceptable salt thereof. It is a novel derivative of neplanocin A and has almost the same level of cytotoxic activity. However, it is not inactivated by the action of adenosine deaminase. It is produced by replacing a hydroxyl at position-6' in neplanocin A or 2', 3'-O-protected neplanocin A with halogen by use of a halogenating agent, and when hydroxyl at position-2' or -3' is protected, removing the protective group thereof.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: February 16, 1993
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Satoshi Shuto, Takumi Obara, Hiromichi Itoh, Takehiro Koshio, Tatsuro Fujiwara, Masao Yaso