Patents by Inventor Takekazu Kubo

Takekazu Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inhibiting activation of a T cell by administering an anti-RGM antibody or an RGM siRNA
    Patent number: 9751938
    Abstract: Provided is a T cell activation inhibitor containing an RGM inhibiting substance such as an anti-RGM neutralizing antibody and the like as an active ingredient. The T cell activation inhibitor is useful as a pharmaceutical composition for the prophylaxis or treatment of autoimmune diseases such as multiple sclerosis and the like, and other diseases caused by T cell activation. In addition, a T cell activation inhibiting substance can be screened for by contacting a test substance with RGM and selecting a test substance that lowers the activity level of RGM.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: September 5, 2017
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Toshihide Yamashita, Takekazu Kubo
  • T CELL ACTIVATION INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND SCREENING METHOD FOR T CELL ACTIVATION INHIBITING SUBSTANCE
    Publication number: 20160244517
    Abstract: Provided is a T cell activation inhibitor containing an RGM inhibiting substance such as an anti-RGM neutralizing antibody and the like as an active ingredient. The T cell activation inhibitor is useful as a pharmaceutical composition for the prophylaxis or treatment of autoimmune diseases such as multiple sclerosis and the like, and other diseases caused by T cell activation. In addition, a T cell activation inhibiting substance can be screened for by contacting a test substance with RGM and selecting a test substance that lowers the activity level of RGM.
    Type: Application
    Filed: May 9, 2016
    Publication date: August 25, 2016
    Applicant: Mitsubishi Tanabe Pharma Corporation
    Inventors: Toshihide YAMASHITA, Takekazu KUBO
  • Method of reducing recurrence of multiple sclerosis symptoms in a mammal by administering an anti-repulsive guidance molecule neutralizing antibody
    Patent number: 9334323
    Abstract: Provided is a T cell activation inhibitor containing an RGM inhibiting substance such as an anti-RGM neutralizing antibody and the like as an active ingredient. The T cell activation inhibitor is useful as a pharmaceutical composition for the prophylaxis or treatment of autoimmune diseases such as multiple sclerosis and the like, and other diseases caused by T cell activation. In addition, a T cell activation inhibiting substance can be screened for by contacting a test substance with RGM and selecting a test substance that lowers the activity level of RGM.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: May 10, 2016
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Toshihide Yamashita, Takekazu Kubo
  • T CELL ACTIVATION INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND SCREENING METHOD FOR T CELL ACTIVATION INHIBITING SUBSTANCE
    Publication number: 20120328633
    Abstract: Provided is a T cell activation inhibitor containing an RGM inhibiting substance such as an anti-RGM neutralizing antibody and the like as an active ingredient. The T cell activation inhibitor is useful as a pharmaceutical composition for the prophylaxis or treatment of autoimmune diseases such as multiple sclerosis and the like, and other diseases caused by T cell activation. In addition, a T cell activation inhibiting substance can be screened for by contacting a test substance with RGM and selecting a test substance that lowers the activity level of RGM.
    Type: Application
    Filed: December 8, 2010
    Publication date: December 27, 2012
    Applicant: Mitsubishi Tanabe Pharma Corporation
    Inventors: Toshihide Yamashita, Takekazu Kubo