Patents by Inventor Takema Hase

Takema Hase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,8-naphthyridin-2-one derivative and use thereof
    Patent number: 5658924
    Abstract: The present invention relates to 1,8-naphthyridin-2-one derivatives, pharmaceutically acceptable acid addition salts and therapeutic agents comprising said compound as an active ingredient, which are used for the diseases such as circulatory diseases and respiratory diseases (e.g. hypertension, renal failure, heart failure, angina pectoris, myocardial infarction, arteriosclerosis, romsoongiitis obliterans, aortitis syndrome, bronchial asthma and peripheral diseases such as peripheral circulatory disorders), central nervous system diseases (e.g. depression, degradatior of central nervous function after cerebrovascular obliteration, cerebrovascular dementia, senile dementia, Alzheimer dementia and memory learning function disorders), various inflammations, and obesity.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 19, 1997
    Assignee: The Green Cross Corporation
    Inventors: Akihiro Matsuura, Naoki Ashizawa, Takema Hase
  • 1,4-benzoxazine-2-acetic acid compound, method for production thereof and use thereof
    Patent number: 5635505
    Abstract: A 1,4-benzoxazine-2-acetic acid compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, a method for production thereof, and a pharmaceutical composition, an aldose reductase inhibitor and an agent for the prevention and/or treatment of the complications of diabetes, which contain the same. The compound (I) of the present invention and pharmaceutically acceptable salts thereof have aldose reductase inhibitory action and are superior in safety. Accordingly, they are useful as an agent for the prevention and/or treatment of the complications of diabetes such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: June 3, 1997
    Assignees: Senju Pharmaceutical Co., Ltd., The Green Cross Corporation
    Inventors: Takahiro Kumonaka, Takema Hase, Tomoji Aotsuka, Toshio Kurihara, Yoshiyuki Nakamura, Tetsuo Matsui, Hiromichi Ishikawa, Fujio Kobayashi
  • Benzothiazole compound, production thereof and use thereof
    Patent number: 5532257
    Abstract: Production of a benzothiazole compound of the formula (I) ##STR1## wherein R.sup.1 is a halogen atom, R.sup.2 and R.sup.3 may be the same or different and each is a hydrogen atom or a halogen atom, R.sup.4 is a hydrogen atom, a halogen atom, a lower alkyl, an alkoxy or an alkyl mercapto and R.sup.5 is a hydrogen atom or a lower alkyl, or a pharmaceutically acceptable salt thereof.The compound of the formula (I) and a pharmaceutically acceptable salt thereof of the present invention have an aldose reductase inhibitory activity in mammals inclusive of human and have superior safety. Accordingly, they are useful as pharmaceutical compositions for the treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, particularly cataract and neurosis.
    Type: Grant
    Filed: November 25, 1994
    Date of Patent: July 2, 1996
    Assignees: Senju Pharmaceutical Co., Ltd, The Green Cross Corporation
    Inventors: Takema Hase, Takahiro Kumonaka, Chikako Shimizu, Hiroshi Hosono, Tomoji Aotsuka, Yoshiyuki Nakamura, Tetsuo Matsui, Hiromichi Ishikawa