Abstract: The present inventors found cyclic peptide compounds that interact with Ras, and non-natural amino acids useful for the production of the cyclic peptide compounds. The inventors also found that the cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: The present inventors found cyclic peptide compounds that interact with Ras, and pharmaceutical compositions containing the cyclic peptide compounds or salts thereof, or solvates thereof.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: The present inventors found cyclic peptide compounds that interact with Ras, and non-natural amino acids useful for the production of the cyclic peptide compounds. The inventors also found that the cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof.

Abstract: In a film supplying device in a package machine, a film drawn out from a film roll is fed downstream between a drive roll and a driven roll. The drive roll is rotatably supported by a first support fixed to a main frame. A second support for rotatably supporting the driven roll is supported on the main frame so as to be rotatable. The second support is movable between a sandwiched position where the driven roll approaches the drive roll to be aligned therewith to hold the film therebetween, and a retract position in which the driven roll is spaced apart from the drive roll.

Abstract: The present inventors have found that when screening for cyclic peptide compounds that can specifically bind to a target molecule, the use of a library including cyclic peptide compounds having a long side chain in the cyclic portion can improve the hit rate for cyclic peptide compounds that can specifically bind to the target molecule. Meanwhile, the present inventors have found that tryptophan and tyrosine residues, which have conventionally been used in oral low molecular-weight pharmaceuticals and are amino acid residues having an indole skeleton or a hydroxyphenyl group, are not suitable for peptides intended to attain high membrane permeability.

Abstract: An axial hydraulic pump-motor, in which a cylinder block having a plurality of cylinder bores on a valve plate having a high-pressure side port and a low-pressure side port for controlling an amount of reciprocation of a piston in each of the cylinder bores, the hydraulic pump-motor includes: a residual pressure release port provided on the valve plate and communicating until the cylinder bore on a top dead center side communicates with the low-pressure side port; a residual pressure acquisition portion obtaining a value of a residual pressure in the cylinder bore on the top dead center side; and a directional switching valve switching a flow path between the residual pressure release port and an hydraulic oil tank and a flow path between the residual pressure release port and the low-pressure side port.

Abstract: When the initiation suppression method was used for translation of a peptide having at its N terminus an amino acid residue carrying a thiol group near its amino group with specific protecting groups being introduced to the thiol group and the amino group, it was found that not only the probability of initiation of amino acid translation reaction was improved, but also production of cleaved peptides was suppressed and translation efficiency and purity were improved. Furthermore, it was found that it is possible to efficiently promote the cyclization reaction of the peptide through amide bond formation. Based on these findings, the inventors discovered novel methods for preparing complexes between nucleic acids and peptides containing various unnatural amino acids and having an amide bond-mediated cyclized portion.

Abstract: An axial-type hydraulic pump/motor in which a cylinder block with a plurality of cylinder bores formed around a rotation axis slides with respect to a valve plate that has a valve plate discharge port and a valve plate suction port, and controls the amount of reciprocation of a piston in each cylinder bore depending on the inclination of a swash plate. Based on the rotational direction of the cylinder block, an opening shape of an end portion on the front side in the rotational direction of a cylinder port and an opening shape of an end portion on the rear side in the rotational direction of the valve plate suction port PB1 have the same shape or partially have the same shape.

Abstract: In a film supplying device in a package machine, a film 12 drawn out from a film roll is fed downstream between a drive roll 32 and a driven roll 34. The drive roll 32 is rotatably supported by a first support 38 fixed to a main frame 26. A second support 56 for rotatably supporting the driven roll 34 is supported on the main frame 26 so as to be rotatable. The second support 56 is movable between a sandwiched position where the driven roll 34 approaches the drive roll 32 to be aligned therewith to hold the film 12 therebetween, and a retract position in which the driven roll 34 is spaced apart from the drive roll 32.

Abstract: An object of the present invention is to provide molecules that bind to a target molecule in a pH dependent manner and a screening method for selecting such molecules. Provided is a screening method for selecting peptides that bind to a target molecule at a first pH and do not bind thereto at a second pH, including a step of preparing a peptide library in which each peptide contains at least one special amino acid that undergoes a pH-dependent change in the charge of the side chain thereof, a step of bringing the peptide library into contact with the target molecule and incubating them under the first pH condition and selecting peptides that bind to the target molecule, and a step of selecting, from the peptides which have bound to the target molecule, peptides that do not bind to the target molecule under the second pH condition.

Abstract: An axial hydraulic pump-motor, in which a cylinder block having a plurality of cylinder bores on a valve plate having a high-pressure side port and a low-pressure side port for controlling an amount of reciprocation of a piston in each of the cylinder bores, the hydraulic pump-motor includes: a residual pressure release port provided on the valve plate and communicating until the cylinder bore on a top dead center side communicates with the low-pressure side port; a residual pressure acquisition portion obtaining a value of a residual pressure in the cylinder bore on the top dead center side; and a directional switching valve switching a flow path between the residual pressure release port and an hydraulic oil tank and a flow path between the residual pressure release port and the low-pressure side port.

Abstract: An axial-type hydraulic pump/motor in which a cylinder block with a plurality of cylinder bores formed around a rotation axis slides with respect to a valve plate that has a valve plate discharge port and a valve plate suction port, and controls the amount of reciprocation of a piston in each cylinder bore depending on the inclination of a swash plate. Based on the rotational direction of the cylinder block, an opening shape of an end portion on the front side in the rotational direction of a cylinder port and an opening shape of an end portion on the rear side in the rotational direction of the valve plate suction port PB1 have the same shape or partially have the same shape.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: An object of the present invention is to provide molecules that bind to a target molecule in a pH dependent manner and a screening method for selecting such molecules. Provided is a screening method for selecting peptides that bind to a target molecule at a first pH and do not bind thereto at a second pH, including a step of preparing a peptide library in which each mRNA contains at least one special amino acid that undergoes a pH-dependent change in the charge of the side chain thereof, a step of bringing the peptide library into contact with the target molecule and incubating them under the first pH condition and selecting peptides that bind to the target molecule, and a step of selecting, from the peptides which have bound to the target molecule, peptides that do not bind to the target molecule under the second pH condition.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: The present embodiments disclose an axial hydraulic pump including a residual pressure regenerating circuit (30) which is a pipe line communicating with a top dead center side communication port (31) and a bottom dead center side communication port (32). Further, the axial hydraulic pump includes cylinder ports (26-1 to 26-8) which are provided in the respective cylinder bores of the cylinder block (6) and are operated with the rotation of the cylinder block (6). Even further, the axial hydraulic pump includes communication holes (41-1 to 41-8) which communicate with the top dead center side communication port (31) and the bottom dead center side communication port (32).

Abstract: A pressure regulating restriction for allowing a cylinder bore and a valve plate discharge port to communicate with each other before the cylinder bore communicates with the valve plate discharge port, and an oil passage for allowing the valve plate discharge port and the cylinder bore to temporarily communicate with each other in a time period after the cylinder bore is freed from the communication with the valve plate suction port until the cylinder bore communicates with the pressure regulating restriction. The oil passage has length capable of transmitting high pressure in the oil passage on a side of the cylinder bore at the time of the communication and of restoring the pressure in the oil passage on the side of the cylinder bore to the pressure on a side of the valve plate discharge port before the communication with a next cylinder bore at the time of non-communication.