Abstract: There is provided technology for promoting permeation of a substance into a cell layer. Provided is a cell layer permeation promoter comprising a compound represented by general formula (1). Also provided is a composition for facilitating drug absorption that contains the cell layer permeation promoter, said composition being for facilitating absorption of a drug into a living body. Also provided is a pharmaceutical composition that contains the cell layer permeation promoter and furthermore contains a drug to be absorbed into a living body.

Abstract: A medical ultrasound device includes: an ultrasound generator and an elongated probe. A cross-sectional surface of the probe at a distal end to which ultrasound oscillation is propagated is perpendicular to a longitudinal direction of the probe, and the cross-sectional surface has a shape identical to a shape of a cross-sectional surface of an anchor to form, in a bone, a bottomed hole for placing the anchor and having a shape to prevent rotation of the anchor in the bottomed hole. An area of the cross-sectional surface of the probe at the distal end is larger than an area of a cross-sectional surface of the probe at a proximal end. The distal end includes a treatment portion that expands outward relative to the proximal end and that is formed in a first direction perpendicular to the longitudinal direction and in a second direction different from the first direction.

Abstract: Ultrasound oscillation can be propagated to a distal end of an elongated probe. A cross-sectional surface of the probe is perpendicular to the length of the probe, and has to the same shape as a shape of a cross-sectional surface of an anchor. The probe is configured to forma bottomed hole in a bone for placing the anchor and the shape of its cross-sectional surface can prevent rotation of the anchor in the bottomed hole. An area of the cross-sectional surface of the probe at the distal end can be larger than an area of a cross-sectional surface of the probe at a proximal end. The distal end of the probe includes a treatment portion that extends outward from a center of the proximal end of the probe in a first direction perpendicular to the longitudinal direction and in a second direction different from the first direction.

Abstract: Ultrasound oscillation can be propagated to a distal end of an elongated probe. A cross-sectional surface of the probe is perpendicular to the length of the probe, and has to the same shape as a shape of a cross-sectional surface of an anchor. The probe is configured to forma bottomed hole in a bone for placing the anchor and the shape of its cross-sectional surface can prevent rotation of the anchor in the bottomed hole. An area of the cross-sectional surface of the probe at the distal end can be larger than an area of a cross-sectional surface of the probe at a proximal end. The distal end of the probe includes a treatment portion that extends outward from a center of the proximal end of the probe in a first direction perpendicular to the longitudinal direction and in a second direction different from the first direction.

Abstract: An ankle arthrodesis of this embodiment performs a cartilage the ultrasonic treatment procedure using an ultrasonic treatment tool. As one condition, when wear of cartilage has attained to the whole of an ankle, it carries out. A method for ankle arthrodesis is disposal which excises the cracked organization which exists in an ankle using the ultrasonic treatment tool, and fixes a tibia and a talus under it with a screw.

Abstract: To provide a nerve stimulation device capable of stimulating a vagus nerve stably while reducing the risk of interrupting a treatment by nerve stimulation due to disconnection or the like. Adopted is a nerve stimulation device including a first electrode and a second electrode disposed in different positions on the vagus nerve, a pulse generating part connected to each of these electrodes, for outputting an electric pulse for stimulating the vagus nerve, and a setting part for switching the electrode to which the electric pulse from the pulse generating part is transmitted.

Abstract: Provided is a heart treatment device (1) including a heartbeat detecting unit (2) that detects heartbeats by using an electrode disposed at a heart (A), a pulse transformer (5) having a primary winding (5a) and a secondary winding (5b), the heartbeat detecting unit (2) being disposed on the side of the primary winding (5a) and the secondary winding (5b) being connected to the vagus nerve (B), and a pulse generating unit (8) that supplies an electric pulse to the primary winding (5a) of the pulse transformer (5) on the basis of the heartbeats detected by the heartbeat detecting unit (2), the electric pulse having a pulse width not exceeding the voltage-time product of the pulse transformer (5).

Abstract: To provide a nerve stimulation device capable of stimulating a vagus nerve stably while reducing the risk of interrupting a treatment by nerve stimulation due to disconnection or the like. Adopted is a nerve stimulation device including a first electrode and a second electrode disposed in different positions on the vagus nerve, a pulse generating part connected to each of these electrodes, for outputting an electric pulse for stimulating the vagus nerve, and a setting part for switching the electrode to which the electric pulse from the pulse generating part is transmitted.

Abstract: To provide a nerve stimulation device capable of stably stimulating a vagus nerve while preventing variation in a cardiac rate reducing effect. Adopted is a nerve stimulation device including a cardiac beat detecting part that detects a cardiac beat of a heart by a second electrode, a pulse generating part that generates a pulse for stimulating a vagus nerve to a first electrode, and a controller that controls a timing of generation of a pulse by the pulse generating part in synchronization with a cardiac cycle detected by the cardiac beat detecting part.

Abstract: Provided is a heart treatment device (1) including a heartbeat detecting unit (2) that detects heartbeats by using an electrode disposed at a heart (A), a pulse transformer (5) having a primary winding (5a) and a secondary winding (5b), the heartbeat detecting unit (2) being disposed on the side of the primary winding (5a) and the secondary winding (5b) being connected to the vagus nerve (B), and a pulse generating unit (8) that supplies an electric pulse to the primary winding (5a) of the pulse transformer (5) on the basis of the heartbeats detected by the heartbeat detecting unit (2), the electric pulse having a pulse width not exceeding the voltage-time product of the pulse transformer (5).

Abstract: An intraperitoneal therapy apparatus for cauterizing tissues in a peritoneal cavity, which comprises a pneumoperitoneal device for introducing gas into the peritoneal cavity, thereby to inflate the cavity, a cautery device for cauterizing diseased tissues in the peritoneal cavity inflated by the pneumoperitoneal device, a suction device for removing fume from the peritoneal cavity, and a control circuit for controlling the pneumoperitoneal device and the suction device in accordance with an operation of the cautery device.

Abstract: An insufflation apparatus intended to insufflate gas supplied from a gas supply source into a cavity of the human body through a gas insufflating pipe, comprising a switch valve for opening and closing a gas supply pipe extending from the gas supply source to the gas insufflating pipe, a cavity pressure measuring unit arranged in the gas supply pipe to measure the pressure in the body cavity, a pressure setting section for setting an intended pressure in the body cavity, an arithmetic unit for calculating the difference of a value measured by the cavity pressure measuring unit relative to the value of pressure set by the pressure setting section, and a changeover control unit for changing over the timings at which the switch valve is opened and closed on the basis of values thus calculated by the arithmetic unit.