Patents by Inventor Takeshi Ichitsuka
Takeshi Ichitsuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6306297Abstract: Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof. A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 &mgr;m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 &mgr;m. A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca10(PO4)6(OH)2, Ca3(PO4)2, Ca2P2O7, Ca(PO3)2, Ca10(PO4)6F2 and Ca10(PO4)6Cl2, said packing material having a dense structure with a porosity of no more than 5%.Type: GrantFiled: January 11, 1995Date of Patent: October 23, 2001Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Takeshi Ichitsuka, Tetsuro Ogawa, Masaya Sumita, Akihiko Yokoo, Katsumi Kawamura
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Patent number: 5651884Abstract: Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.Type: GrantFiled: June 6, 1995Date of Patent: July 29, 1997Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Takeshi Ichitsuka, Tetsuro Ogawa, Katsumi Kawamura, Masaya Sumita, Akihiko Yokoo
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Patent number: 5651882Abstract: Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.Type: GrantFiled: January 11, 1995Date of Patent: July 29, 1997Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Takeshi Ichitsuka, Tetsuro Ogawa, Katsumi Kawamura, Akihiko Yokoo
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Patent number: 5441635Abstract: Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.Type: GrantFiled: March 10, 1993Date of Patent: August 15, 1995Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Takeshi Ichitsuka, Tetsuro Ogawa, Masaya Sumita
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Patent number: 5240659Abstract: An oriented shaped article of a calcium phosphate type compound is disclosed, in which at least two crystallographic axes of the primary particles of which the shaped article is composed each is oriented in one direction, respectively, in at least the surface of said article. A sinter of the oriented shaped article and a processes for producing the article and the sinter are also disclosed.Type: GrantFiled: March 24, 1992Date of Patent: August 31, 1993Assignee: Asahi Kogaku K.K.Inventors: Takeshi Ichitsuka, Tetsuro Ogawa, Masaya Sumita, Akihiko Yokoo
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Patent number: 5134009Abstract: An oriented shaped article of a calcium phosphate type compound is disclosed, in which at least two crystallographic axes of the primary particles of which the shaped article is composed each is oriented in one direction, respectively, in at least the surface of said article. A sinter of the oriented shaped article and a processes for producing the article and the sinter are also disclosed.Type: GrantFiled: September 14, 1989Date of Patent: July 28, 1992Assignee: Asahi Kogaku Kogyo K.K.Inventors: Takeshi Ichitsuka, Tetsuro Ogawa, Masaya Sumita, Akihiko Yokoo
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Patent number: 5089195Abstract: A method for producing a calcium phosphate-based material comprising:(a) molding a calcium phosphate powder;(b) preliminarily calcining the resulting molding in a vacuum or under a reduced pressure until the relative density is 95% or more; and(c) firing the molding in air, an inert gas, or nitrogen gas.Type: GrantFiled: June 22, 1990Date of Patent: February 18, 1992Assignee: Asahi Kogaku Kogyo K.K.Inventors: Takeshi Ichitsuka, Yasuhiko Hirayama, Tetsuro Ogawa
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Patent number: 5085781Abstract: A separating agent which includes a polyvinyl acetal resin having open cell structure and an average pore size of from about 10 to about 1000 micrometers; and, porous calcium phosphate granules having open cell structure, and also having two distributions of pore size wherein one distribution has micropores ranging from about 20 to about 500 nm in average pore size and the other distribution has small pores ranging from about 1 to about 50 micrometers in average pore size. Alternatively, the separating agent includes a polyvinyl acetal resin having open cell structure and having an average pore size of from about 10 to about 1000 micrometers as a first element, and a layer of porous calcium phosphate granules having an average granule size of from about 10 to about 2000 micrometers as a second element applied onto the first element. The separating agents may be used in a separator, and may be employed in separating methods.Type: GrantFiled: February 28, 1990Date of Patent: February 4, 1992Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Sumiaki Tsuru, Akihiko Yokoo, Takeshi Ichitsuka, Tsuneo Hiraide
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Patent number: 5064436Abstract: A bone prosthetic material composed of calcium phosphate group granules which have open cells with an average pore size of 0.01-(10 .mu.m).sup.2 over a surface density of at least one per 10 .mu.m.sup.2. The prosthetic material is prepared by mixing organic inflammable particles with a calcium based powder, granulating and then firing the mixture.Type: GrantFiled: July 3, 1989Date of Patent: November 12, 1991Assignee: Asahi Kogaku Kogyo K.K.Inventors: Makoto Ogiso, Tetsuro Ogawa, Takeshi Ichitsuka, Masahide Inoue
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Patent number: 5055307Abstract: Slow release drug delviery granules comprising porous granules of a calcium phosphate compound having an atomic ratio of Ca to P of 1.3 to 1.8, a porosity of 0.1 to 70%, a specific surface area of 0.1 to 50 m.sup.2 /g and a pore size of 1 nm to 10 .mu.m, fired at a temperature of 200.degree. to 1400.degree. C., and a drug component impregnated in pores of the granules, and a process for producing the same. The drug delivery granules of the present invention have a controllable, prolonged effect of drug release and a good imaging property to an X-ray or ultrasonic wave, and therefore can be advantageously utilized in the field of chemotherapy.Type: GrantFiled: December 28, 1989Date of Patent: October 8, 1991Assignee: Asahi Kagaku Kogyo Kabushiki KaishaInventors: Sumiaki Tsuru, Masashi Tsugita, Ken Takasaki, Akihiko Yokoo, Takeshi Ichitsuka
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Patent number: 5039408Abstract: Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.Type: GrantFiled: January 8, 1990Date of Patent: August 13, 1991Assignee: Asahi Kogaku Kogyo K.K.Inventors: Takeshi Ichitsuka, Tetsuro Ogawa, Masaya Sumita, Akihiko Yokoo, Katsumi Kawamura
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Patent number: 4957674Abstract: A method for producing a calcium phosphate-based material comprising:(a) molding a calcium phosphate powder;(b) preliminarily calcining the resulting molding in a vacuum or under a reduced pressure until the relative density is 95% or more; and(c) firing the molding in air, an inert gas, or nitrogen gas.Type: GrantFiled: May 11, 1988Date of Patent: September 18, 1990Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Takeshi Ichitsuka, Yasuhiko Hirayama, Tetsuro Ogawa
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Patent number: 4798585Abstract: A support for a biomedical implant device in which the support has a surface layer composed of a biocompatible calcium phosphate material such as sintered hydroxyapatite with a porosity of 50-60% and pore size of 0.5-500 micrometers. Preferably, the surface layer is formed with projections or recesses of a few hundred micrometers size.Type: GrantFiled: June 8, 1987Date of Patent: January 17, 1989Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Masahide Inoue, Takeshi Ichitsuka, Yasuhiko Hirayama, Shozo Koshikawa, Tateki Kitaoka, Nobuo Nakabayashi, Tatsumichi Takeda, Osamu Minoo
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Patent number: RE34037Abstract: A support for a biomedical implant device in which the support has a surface layer composed of a biocompatible calcium phosphate material such as sintered hydroxyapatite with a porosity of 50-60% and pore size of 0.5-500 micrometers. Preferably, the surface layer is formed with projections or recesses of a few hundred micrometers size.Type: GrantFiled: January 17, 1991Date of Patent: August 18, 1992Assignee: Asahi Kogaku Kogyo K.K.Inventors: Masahide Inoue, Takeshi Ichitsuka, Yasuhiko Hirayama, Shozo Koshikawa, Tateki Kitaoka, Nobuo Nakabayashi, Tatsumichi Takeda, Osamu Minoo
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Patent number: RE35267Abstract: A separating agent which includes a polyvinyl acetal resin having open cell structure and an average pore size of from about 10 to about 1000 micrometers; and, porous calcium phosphate granules having open cell structure, and also having two distributions of pore size wherein one distribution has micropores ranging from about 20 to about 500 mm in average pore size and the other distribution has small pores ranging from about 1 to about 50 micrometers in average pore size. Alternatively, the separating agent includes a polyvinyl acetal resin having open cell structure and having an average pore size of from about 10 to about 1000 micrometers as a first element, and a layer of porous calcium phosphate granules having an average granule size of from about 10 to about 2000 micrometers as a second element applied onto the first element. The separating agents may be used in a separator, and may be employed in separating methods.Type: GrantFiled: February 3, 1994Date of Patent: June 11, 1996Assignee: Asahi Kogaku Kogyo Kabushiki KaishaInventors: Sumiaki Tsuru, Takeshi Ichitsuka, Akihiko Yokoo, Tsuneo Hiraide
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Patent number: RE35340Abstract: Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.Type: GrantFiled: August 13, 1993Date of Patent: October 1, 1996Assignee: Asahi Kogaku Kogyo K.K.Inventors: Takeshi Ichitsuka, Tetsuro Ogawa, Katsumi Kawamura, Masaya Sumita, Akihiko Yokoo