Patents by Inventor Takeshi Imanishi
Takeshi Imanishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230257413Abstract: Disclosed is a compound represented by formula (1) or a salt thereof wherein: “Base” represents an aromatic heterocyclic group which may have a substituent, or an aromatic hydrocarbon ring group which may have a substituent; A1 represents a single bond or an alkylene group; R1 to R5 represent an atom or a group disclosed in the specification.Type: ApplicationFiled: March 24, 2023Publication date: August 17, 2023Applicant: RIKEN GENESIS CO., LTD.Inventors: Haruhisa YOSHIKAWA, Ikuya BAN, Takeshi IMANISHI
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Publication number: 20220089634Abstract: Disclosed is a compound represented by formula (1) or a salt thereof: (wherein: “Base” represents an aromatic heterocyclic group which may have a substituent or an aromatic hydrocarbon ring group which may have a substituent; A1 represents a linear alkylene group; A2 represents a single bond or an alkylene group; X represents an alkylene group, —O— or —S(?O)k—; R1 and R2 are the same as or different from each other and independently represent a hydrogen atom, etc.; and R3 represents an amino group which may have a substituent).Type: ApplicationFiled: September 28, 2021Publication date: March 24, 2022Applicant: SYSMEX CORPORATIONInventors: Ikuya BAN, Haruhisa YOSHIKAWA, Ayako ORITA, Takeshi IMANISHI
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Patent number: 10421334Abstract: An electric compressor mounted to a vehicle includes a motor, a compression unit driven by the motor, an inverter unit for driving the motor, a housing for accommodating the motor, the compression unit, and the inverter unit, and a cover mounted to the housing for closing a space accommodating the inverter unit. The electric compressor is fixed to the vehicle by means of a first mounting leg provided to the housing, and a second mounting leg provided to the cover. The second mounting leg includes a stress concentration part at which stress concentrates as compared with another portion of the second mounting leg.Type: GrantFiled: November 17, 2015Date of Patent: September 24, 2019Assignee: Panasonic Intellectual Property Management Co., Ltd.Inventors: Kei Nishibori, Makoto Iwasa, Nobuaki Ogawa, Takeshi Imanishi, Yoshifumi Abe
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Patent number: 10253360Abstract: The invention provides a method of selectively amplifying a detection target nucleic acid by inhibiting amplification of a detection non-target nucleic acid (e.g., wild-type gene) in a test sample by using, in a nucleic acid amplification reaction, an oligonucleotide analog containing one or more kinds of one or more unit structures of various nucleoside analogs represented by the following formula (I): wherein the symbols are as defined in the DESCRIPTION, and the like, or a salt thereof, as a clamp nucleic acid, and detecting the amplified nucleic acid.Type: GrantFiled: September 27, 2013Date of Patent: April 9, 2019Assignee: BNA INC.Inventors: Takeshi Imanishi, Ayako Orita, Ikuya Ban
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Publication number: 20170259647Abstract: An electric compressor mounted to a vehicle includes a motor, a compression unit driven by the motor, an inverter unit for driving the motor, a housing for accommodating the motor, the compression unit, and the inverter unit, and a cover mounted to the housing for closing a space accommodating the inverter unit. The electric compressor is fixed to the vehicle by means of a first mounting leg provided to the housing, and a second mounting leg provided to the cover. The second mounting leg includes a stress concentration part at which stress concentrates as compared with another portion of the second mounting leg.Type: ApplicationFiled: November 17, 2015Publication date: September 14, 2017Inventors: KEI NISHIBORI, MAKOTO IWASA, NOBUAKI OGAWA, TAKESHI IMANISHI, YOSHIFUMI ABE
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Patent number: 9200633Abstract: A scroll compressor is characterized in that by reducing an Oldham ring 57 and an orbiting scroll 12 in size, a compressing mechanism 4 is reduced in size, a pair of scroll-side keys 57b are disposed at locations deviated from each other from a diameter line of the ring portion 57a so that a distance between the pair of scroll-side keys 57b becomes not less than a width of the scroll-side keyway 12d, and a pair of main bearing-side keys 57c are disposed at locations deviated from each other from the diameter line of the ring portion 57a so that a distance between the pair of main bearing-side keys 57c becomes not less than a width of the main bearing-side keyways 51a.Type: GrantFiled: November 16, 2011Date of Patent: December 1, 2015Assignee: Panasonic Intellectual Property Management Co., Ltd.Inventors: Sadayuki Yamada, Manabu Sakai, Takeshi Imanishi, Atsushi Sakuda
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Patent number: 9127280Abstract: An object of the present invention is to provide an oligonucleotide useful as a therapeutic agent for dyslipidemia that has excellent binding affinity to the PCSK9 gene as well as stability and safety. The oligonucleotide of the present invention contains a sugar-modified nucleoside, the sugar-modified nucleoside has a bridging structure between 4?-position and 2?-position, and the oligonucleotide can bind to the human PCSK9 gene. Also, the present invention provides a therapeutic agent for dyslipidemia containing the oligonucleotide as an active ingredient, and the therapeutic agent preferably contains a bioabsorbable material as a carrier. The bioabsorbable material is preferably atelocollagen or peptide gel.Type: GrantFiled: August 31, 2011Date of Patent: September 8, 2015Assignees: Osaka University, National Cerebral and Cardiovascular Center, Tokyo University of Science Education Foundation Administrative OrganizationInventors: Satoshi Obika, Takeshi Imanishi, Tsuyoshi Yamamoto, Keisuke Narukawa, Mariko Shiba, Tetsuji Yamaoka, Hidetaka Torigoe, Atsushi Yamashita, Yoichi Tachibana, Sachiro Kakinoki, Kiyomi Sasaki
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Publication number: 20150240299Abstract: The invention provides a method of selectively amplifying a detection target nucleic acid by inhibiting amplification of a detection non-target nucleic acid (e.g., wild-type gene) in a test sample by using, in a nucleic acid amplification reaction, an oligonucleotide analog containing one or more kinds of one or more unit structures of various nucleoside analogs represented by the following formula (I): wherein the symbols are as defined in the DESCRIPTION, and the like, or a salt thereof, as a clamp nucleic acid, and detecting the amplified nucleic acid.Type: ApplicationFiled: September 27, 2013Publication date: August 27, 2015Applicant: BNA INC.Inventors: Takeshi Imanishi, Ayako Orita, Ikuya Ban
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Patent number: 8957201Abstract: A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.Type: GrantFiled: July 22, 2010Date of Patent: February 17, 2015Assignee: Daiichi Sankyo Company, LimitedInventors: Masakatsu Kaneko, Koji Morita, Takeshi Imanishi
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Patent number: 8680260Abstract: The present invention provides an 18F-labeled azide compound usable in the Huisgen reaction which enables 18F-labeling although only a small quantity of alkyne compound is available as a counterpart substrate, more specifically the 18F-labeled azide compound enabling the PET to be applied to peptides or oligonucleotides and enabling the 18F-labeling of any sites of oligonucleotide other than the 5? end or 3? end thereof, a reagent for 18F-labeling, and a method for 18F-labeling of an alkyne compound using the same.Type: GrantFiled: May 14, 2010Date of Patent: March 25, 2014Assignee: RikenInventors: Yasuyoshi Watanabe, Masaaki Suzuki, Hisashi Doi, Takeshi Kuboyama, Satoshi Obika, Takeshi Imanishi
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Publication number: 20130172402Abstract: An object of the present invention is to provide an oligonucleotide useful as a therapeutic agent for dyslipidemia that has excellent binding affinity to the PCSK9 gene as well as stability and safety. The oligonucleotide of the present invention contains a sugar-modified nucleoside, the sugar-modified nucleoside has a bridging structure between 4?-position and 2?-position, and the oligonucleotide can bind to the human PCSK9 gene. Also, the present invention provides a therapeutic agent for dyslipidemia containing the oligonucleotide as an active ingredient, and the therapeutic agent preferably contains a bioabsorbable material as a carrier. The bioabsorbable material is preferably atelocollagen or peptide gel.Type: ApplicationFiled: August 31, 2011Publication date: July 4, 2013Applicants: Osaka University, Tokyo University of Science Educational Foundation Administrative Organization, National Cerebral and Cardiovascular CenterInventors: Satoshi Obika, Takeshi Imanishi, Tsuyoshi Yamamoto, Keisuke Narukawa, Mariko Shiba, Tetsuji Yamaoka, Hidetaka Torigoe, Atsushi Yamashita, Yoichi Tachibana, Sachiro Kakinoki, Kiyomi Sasaki
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Publication number: 20120308422Abstract: A scroll compressor is characterized in that by reducing an Oldham ring 57 and an orbiting scroll 12 in size, a compressing mechanism 4 is reduced in size, a pair of scroll-side keys 57b are disposed at locations deviated from each other from a diameter line of the ring portion 57a so that a distance between the pair of scroll-side keys 57b becomes not less than a width of the scroll-side keyway 12d, and a pair of main bearing-side keys 57c are disposed at locations deviated from each other from the diameter line of the ring portion 57a so that a distance between the pair of main bearing-side keys 57c becomes not less than a width of the main bearing-side keyways 51a.Type: ApplicationFiled: November 16, 2011Publication date: December 6, 2012Applicant: PANASONIC CORPORATIONInventors: Sadayuki Yamada, Manabu Sakai, Takeshi Imanishi, Atsushi Sakuda
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Patent number: 7994145Abstract: Oligonucleotide analogues which have anti-sense or anti-gene activity, as well as in vivo stability, or pharmaceutically acceptable salts thereof. The oligonucleotide analogues have one or more structural units represented by the following formula (1a): provided that when the oligonucleotide has two or more structural units of formula (1a), each B is the same or different, wherein B represents a purin-9-yl group or a 2-oxo-1,2-dihydropyrimidin-1-yl group.Type: GrantFiled: January 31, 2007Date of Patent: August 9, 2011Assignee: Takeshi ImanishiInventors: Takeshi Imanishi, Satoshi Obika
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Publication number: 20110009471Abstract: A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: July 22, 2010Publication date: January 13, 2011Applicants: DAIICHI SANKYO COMPANY, LIMITED, MITSUBISHI-KAGAKU FOODS CORPORATIONInventors: Masakatsu Kaneko, Koji Morita, Takeshi Imanishi
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Patent number: 7816333Abstract: A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.Type: GrantFiled: July 27, 2007Date of Patent: October 19, 2010Assignees: Daiichi Sankyo Company, Limited, Mitsubishi-Kagaku Foods CorporationInventors: Masakatsu Kaneko, Koji Morita, Takeshi Imanishi
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Patent number: 7615619Abstract: A nucleotide analogue compound represented by formula (1) and salts thereof. In formula (1), A represents a direct bond, C1-4 alkylene, etc.; B represents an optionally substituted aromatic heterocyclic groups; and R1, R2, R3 and R4 each represents hydrogen, an amino-protecting group, a hydroxyl-protecting group, a phosphate group, or —P(R7)R8, wherein R7 and R8 each represents hydroxyl, protected hydroxyl, mercapto, protected mercapto, etc. The compounds are useful as nucleotide analogues for producing oligonucleotide analogues useful in an antisense method and for producing intermediates thereof.Type: GrantFiled: February 13, 2003Date of Patent: November 10, 2009Assignee: Takeshi ImanishiInventors: Takeshi Imanishi, Satoshi Obika
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Publication number: 20090149404Abstract: A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: July 27, 2007Publication date: June 11, 2009Applicants: DAIICHI SANKYO COMPANY, LIMITED, MITSUBISHI-KAGAKU FOODS CORPORATIONInventors: Masakatsu Kaneko, Koji Morita, Takeshi Imanishi
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Patent number: 7427672Abstract: An oligonucleotide analogue useful for the antisense method, etc., having excellent enzyme resistance, having potent selective binding affinity for single-stranded RNA, and further having an excellent triplex-forming capacity with double-stranded DNA, and a nucleoside analogue useful for its production are provided. Nucleoside analogues, which are compounds of the general formula (I) and salts thereof, and oligonucleotide analogues containing one or more of the nucleoside analogues: where Base is an aromatic heterocyclic group or the like optionally having a substituent; R1, R2 and R3 are each a hydrogen atom, a protective group for an amino group, a protective group for a hydroxyl group, a phosphate group, or —P(R4)R5 [where R4 and R5 are each a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, etc.]; m=0 to 2; and n=1 to 3].Type: GrantFiled: August 25, 2004Date of Patent: September 23, 2008Inventors: Takeshi Imanishi, Satoshi Obika, Kazuyuki Miyashita
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Patent number: 7335765Abstract: A compound of the formula (1): wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R3)R4, wherein R3 and R4 are the same or different and represent a hydroxyl group, an amino group, an alkoxy group having from 1 to 4 carbon atoms, a cyanoalkoxy group having from 1 to 5 carbon atoms or an amino group substituted by an alkyl group having from 1 to 4 carbon atoms; A represents an alkylene group having from 1 to 4 carbon atoms and B represents a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group or a substituted 2-oxo-pyrimidin-1-yl group having a substituent ? selected from the group consisting of a hydroxyl group which may be protected, an alkoxy group having from 1 to 4 carbon atoms, a mercapto group which may be protected, an alkylthio group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, an amino group which may be protected, a mono- or di-alkylamino group which may bType: GrantFiled: August 9, 2001Date of Patent: February 26, 2008Assignees: Daiichi Sankyo Company, Limited, Mitsubishi-Kagaku Foods CorporationInventors: Masakatsu Kaneko, Koji Morita, Takeshi Imanishi
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Patent number: RE44779Abstract: An oligo- or polynucleotide analogue having one or more structures of the general formula where B is a pyrimidine or purine nucleic acid base, or an analogue thereof, is disclosed. The use of this analogue provides an oligonucleotide analogue antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized.Type: GrantFiled: June 26, 2012Date of Patent: February 25, 2014Assignees: Santaris Pharma A/S, Exiqon A/SInventors: Takeshi Imanishi, Satoshi Obika