Patents by Inventor Takeshi Jimbo
Takeshi Jimbo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11806339Abstract: The present invention provides a medicament comprising a compound represented by general formula (1) which has Axl inhibitory activity, and an EGFR tyrosine kinase inhibitor in combination, and a method for treating cancer using this combination. The present invention provides an excellent medicament and method for treating cancer which is highly effective for inhibiting resistance to an EGFR tyrosine kinase inhibitor in cancer treatment, and causes less adverse reactions such as weight loss.Type: GrantFiled: May 2, 2022Date of Patent: November 7, 2023Assignee: Daiichi Sankyo Company, LimitedInventor: Takeshi Jimbo
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Publication number: 20230025510Abstract: The present invention provides a novel compound or a pharmaceutically acceptable salt thereof having an inhibitory action on an EGFR tyrosine kinase having an exon 20 insertion mutation and/or a HER2 tyrosine kinase having an exon 20 insertion mutation, a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, R5 and R6 in the Formula (I) are each as defined in the description.Type: ApplicationFiled: July 3, 2019Publication date: January 26, 2023Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Kenichi Yoshida, Kosuke Takeuchi, Hidekazu Inoue, Hideaki Kageji, Takayuki Momose, Keisuke Yoshida, Takeshi Jimbo, Akiko Egami
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Publication number: 20220331302Abstract: The present invention provides a medicament comprising a compound represented by general formula (1) which has Axl inhibitory activity, and an EGFR tyrosine kinase inhibitor in combination, and a method for treating cancer using this combination. The present invention provides an excellent medicament and method for treating cancer which is highly effective for inhibiting resistance to an EGFR tyrosine kinase inhibitor in cancer treatment, and causes less adverse reactions such as weight loss.Type: ApplicationFiled: May 2, 2022Publication date: October 20, 2022Inventor: Takeshi Jimbo
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Patent number: 11318124Abstract: The present invention provides a medicament comprising a compound represented by general formula (1) which has Axl inhibitory activity, and an EGFR tyrosine kinase inhibitor in combination, and a method for treating cancer using this combination. The present invention provides an excellent medicament and method for treating cancer which is highly effective for inhibiting resistance to an EGFR tyrosine kinase inhibitor in cancer treatment, and causes less adverse reactions such as weight loss.Type: GrantFiled: March 23, 2018Date of Patent: May 3, 2022Assignee: Daiichi Sankyo Company, LimitedInventor: Takeshi Jimbo
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Publication number: 20220002277Abstract: It is intended to provide a novel compound or a salt thereof, or crystals of the compound or the salt, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl. [Solution] The present invention provides a pyridone derivative having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or a salt thereof, or crystals of the compound or the salt (wherein R1, R2, R3, R4, R5, W, X, Y, and Z are each as defined in the specification).Type: ApplicationFiled: August 12, 2021Publication date: January 6, 2022Inventors: Noriyasu HAGINOYA, Takashi SUZUKI, Miho HAYAKAWA, Masahiro OTA, Tomoharu TSUKADA, Katsuhiro KOBAYASHI, Yosuke ANDO, Takeshi JIMBO, Koichi NAKAMURA
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Patent number: 11208403Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.Type: GrantFiled: September 18, 2019Date of Patent: December 28, 2021Assignee: Daiichi Sankyo Company, LimitedInventors: Noriyasu Haginoya, Takashi Suzuki, Miho Hayakawa, Masahiro Ota, Tomoharu Tsukada, Katsuhiro Kobayashi, Yosuke Ando, Takeshi Jimbo, Koichi Nakamura
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Publication number: 20200345709Abstract: The present invention provides a medicament comprising a compound represented by general formula (1) which has Axl inhibitory activity, and an EGFR tyrosine kinase inhibitor in combination, and a method for treating cancer using this combination. The present invention provides an excellent medicament and method for treating cancer which is highly effective for inhibiting resistance to an EGFR tyrosine kinase inhibitor in cancer treatment, and causes less adverse reactions such as weight loss.Type: ApplicationFiled: March 23, 2018Publication date: November 5, 2020Inventor: Takeshi JIMBO
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Publication number: 20200010458Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.Type: ApplicationFiled: September 18, 2019Publication date: January 9, 2020Inventors: Noriyasu HAGINOYA, Takashi SUZUKI, Miho HAYAKAWA, Masahiro OTA, Tomoharu TSUKADA, Katsuhiro KOBAYASHI, Yosuke ANDO, Takeshi JIMBO, Koichi NAKAMURA
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Patent number: 10442797Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.Type: GrantFiled: July 6, 2015Date of Patent: October 15, 2019Assignee: DAIICHI SANKYO COMPANY, LIMITEDInventors: Noriyasu Haginoya, Takashi Suzuki, Miho Hayakawa, Masahiro Ota, Tomoharu Tsukada, Katsuhiro Kobayashi, Yosuke Ando, Takeshi Jimbo, Koichi Nakamura
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Publication number: 20180148436Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.Type: ApplicationFiled: July 6, 2015Publication date: May 31, 2018Inventors: Noriyasu HAGINOYA, Takashi SUZUKI, Miho HAYAKAWA, Masahiro OTA, Tomoharu TSUKADA, Katsuhiro KOBAYASHI, Yosuke ANDO, Takeshi JIMBO, Koichi NAKAMURA
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Publication number: 20170183329Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.Type: ApplicationFiled: July 6, 2015Publication date: June 29, 2017Inventors: Noriyasu HAGINOYA, Takashi SUZUKI, Miho HAYAKAWA, Masahiro OTA, Tomoharu TSUKADA, Katsuhiro KOBAYASHI, Yosuke ANDO, Takeshi JIMBO, Koichi NAKAMURA
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Patent number: 8933103Abstract: Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R1, R2, R3, R5, R6, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.Type: GrantFiled: January 30, 2013Date of Patent: January 13, 2015Assignee: Daiichi Sankyo Company, LimitedInventors: Hitoshi Ohki, Masahiro Ota, Kosuke Takeuchi, Hideaki Watanabe, Akitake Yamaguchi, Yoshihiro Shibata, Yuichi Tominaga, Takeshi Jimbo, Keijiro Kobayashi, Katsuhiro Kobayashi, Daisuke Fukatsu
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Publication number: 20130281428Abstract: Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R1, R2, R3, R5, R6, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.Type: ApplicationFiled: January 30, 2013Publication date: October 24, 2013Inventors: Hitoshi Ohki, Masahiro Ota, Kosuke Takeuchi, Hideaki Watanabe, Akitake Yamaguchi, Yoshihiro Shibata, Yuichi Tominaga, Takeshi Jimbo, Keijiro Kobayashi, Katsuhiro Kobayashi, Daisuke Fukatsu
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Patent number: 5010862Abstract: Disclosed is a method for controlling the quantity of intake air supplied to an internal combustion engine, in which the position of a valve member of a flow control valve having a non-linear valve opening characteristic is converted into an intake air quantity or a virtual valve position proportional to the intake air quantity so as to linearize the non-linear valve opening characteristic of the flow control valve. Application of the method of the present invention to an idle speed control device in an engine equipped with an electronic controlled fuel injection system is advantageous in that the quantity of intake air supplied to the engine can be accurately controlled under various operating conditions of the engine, therely preventing rotation of the engine at an excessively high speed and stalling of the engine, improving the fuel consumption and reducing noise generated from the engine.Type: GrantFiled: February 21, 1990Date of Patent: April 30, 1991Assignee: Mitsubishi Jidosha Kogyo Kabushiki KaishaInventors: Toru Hashimoto, Hitoshi Kamura, Katutoshi Yoshida, Takeshi Jimbo, Tokushige Inuzuka
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Patent number: 4834054Abstract: A method of detecting a fault of an exhaust gas recirculation system of an internal combustion engine, comprising detecting a temperature relating to a temperature of a gas recirculating through the exhaust gas recirculation system when the system is in a condition in which the system should be operated to return part of an exhaust gas of the engine to an intake passage, and detecting that the exhaust gas recirculation system is defective when the detected temperature is lower than a fault discriminating value. A condition of air to be sucked into the engine, such as intake air temperature and atmospheric pressure, is detected, and the fault discriminating value is set in accordance with the detected air condition, whereby abnormality or fault of the exhaust gas recirculation system can be detected accurately and reliably.Type: GrantFiled: April 5, 1988Date of Patent: May 30, 1989Assignee: Mitsubishi Jidosha Kogyo Kabushiki KaishaInventors: Toru Hashimoto, Akira Takahashi, Takeshi Imaizumi, Susumu Saito, Hiroshi Tanaka, Takeshi Jimbo