Abstract: The present invention provides a recombinant HSV having the ability to specifically kill tumor cells such as human glioma cells in vivo, useful and safe for treating human glioma, etc. and that can easily put to clinical use. A new recombinant HSV, KeM345, is constructed by inserting a ?34.5 gene transcription unit, which is expressed by Musashi1 promoter, into a ribonucleotide reductase gene site of the genome of a herpes simplex virus (HSV) previously attenuated, by means of homologous recombination and obtained as a purified strain. Since KeM345 is a recombinant virus itself, it can not only induce viral proliferation by being transmitted to culture cells but can also induce viral replication equivalent to that of wild-type HSV, showing an excellent cytotoxic effect (cytolytic ability) selectively upon a malignant glioma.

Abstract: The present invention provides a recombinant HSV having the ability to specifically kill tumor cells such as human glioma cells in vivo, useful and safe for treating human glioma, etc. and that can easily put to clinical use. A new recombinant HSV, KeM345, is constructed by inserting a ?34.5 gene transcription unit, which is expressed by Musashil promoter, into a ribonucleotide reductase gene site of the genome of a herpes simplex virus (HSV) previously attenuated, by means of homologous recombination and obtained as a purified strain. Since KeM345 is a recombinant virus itself, it can not only induce viral proliferation by being transmitted to culture cells but can also induce viral replication equivalent to that of wild-type HSV, showing an excellent cytotoxic effect (cytolytic ability) selectively upon a malignant glioma.

Abstract: The present invention provides a human glioma antigen or a method for preparing the same, which can be applied to diagnosis and therapy of glioma. A glioma antigen or a glioma antigen gene is prepared by a process comprising the steps of: total RNA is extracted from a glioma cell line and cDNA was synthesized; &lgr; phage cDNA library, which was constructed by infection of E. coli caused by introducing said cDNA into &lgr; phage vector, and the sera of glioma patients are made to react; positive clones to which antibodies in the serum reacted are detected with the use of labeled anti-IgG antibodies; screening is repeated several times for the detected positive clones; antigens are isolated from positive clones confirmed to be antibody-reactive; serum screening is conducted by using the isolated antigens, the sera of glioma patients and healthy persons.

Abstract: A built-in electrode type susceptor having excellent corrosion resistance and plasma resistance is obtained. A placement plate and a support plate made of ceramics are prepared, fixation holes are formed in this support plate, and feeding terminals consisting of a conductive composite ceramics are fitted into these fixation holes so as to penetrate through the support plate. A conductive material layer consisting of a conductive composite ceramics is formed on this support plate so as to come into contact with the feeding terminals, and the support plate and the placement plate are overlapped on each other via the conductive material layer on the support plate, and subjected to sintering and heat treatment under application of pressure, to thereby integrate these plates. Also, the conductive material layer is used as an internal electrode consisting of a conductive composite ceramics sintered body, to thereby obtain a built-in electrode type susceptor.

Abstract: A monolithic structure for use as a pressure bulkhead for an aircraft includes a first web, a redundant second web spaced from the first web, stiffeners disposed between and connecting the webs to each other, and first and second outer attachment rings respectively provided on the outer peripheries of the first and second webs for attaching the bulkhead to fuselage structure. One of the webs comprises a pressure web for supporting pressure loading, and the other web defines at least one aperture therethrough. The stiffeners are integrally fabricated along with at least one of the webs and associated attachment ring as a one-piece monolithic part.

Abstract: A built-in electrode type susceptor having excellent corrosion resistance and plasma resistance is obtained.

Abstract: A monolithic structure for use as a pressure bulkhead for an aircraft includes a first web, a redundant second web spaced from the first web, stiffeners disposed between and connecting the webs to each other, and first and second outer attachment rings respectively provided on the outer peripheries of the first and second webs for attaching the bulkhead to fuselage structure. One of the webs comprises a pressure web for supporting pressure loading, and the other web defines at least one aperture therethrough. The stiffeners are integrally fabricated along with at least one of the webs and associated attachment ring as a one-piece monolithic part.

Abstract: A monolithic structure for use as a pressure bulkhead for an aircraft includes a first web, a redundant second web spaced from the first web, stiffeners disposed between and connecting the webs to each other, and first and second outer attachment rings respectively provided on the outer peripheries of the first and second webs for attaching the bulkhead to fuselage structure. One of the webs comprises a pressure web for supporting pressure loading, and the other web defines at least one aperture therethrough. The stiffeners are integrally fabricated along with at least one of the webs and associated attachment ring as a one-piece monolithic part.

Abstract: A ball valve for medium and low pressure service includes a valve body, a valve member positioned in the valve body, circlips attached to the valve body, and provided at the upstream side and downstream side of the valve member, and sealing members provided between respective of the circlips and the valve member. The circlips are urged toward the valve member via the sealing members and are kept in a floating state. The valve member is of spherical shape, having a first and a second fluid passage holes and a valve stem groove and does not include a seam.