Abstract: To improve durability by preventing breakage of each roller piece for a long time. It is a pressure roller for pressing a surface of a tire member made from an unvulcanized rubber member. The pressure roller has a support shaft and a plurality of elastically deformable roller pieces supported by the support shaft and arranged in the axial direction of the support shaft. Each roller piece has a pressing surface for contacting with the surface of the tire member. Each roller piece is independently rotatably supported by the support shaft.

Abstract: To improve durability by preventing breakage of each roller piece for a long time. It is a pressure roller for pressing a surface of a tire member made from an unvulcanized rubber member. The pressure roller has a support shaft and a plurality of elastically deformable roller pieces supported by the support shaft and arranged in the axial direction of the support shaft. Each roller piece has a pressing surface for contacting with the surface of the tire member. Each roller piece is independently rotatably supported by the support shaft.

Abstract: There is provided a novel triazinone compound that has an excellent T-type voltage-dependent calcium channel inhibitory activity and is specifically useful for treatment of pain. A compound of Formula (I), a tautomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof: where each substituent is defined in detail in the description or claims, for example R1 is H or C1-6 alkoxy, etc., each of L1 and L2 is independently a single bond or NR2, etc., L3 is C1-6 alkylene, etc., A is C6-14 aryl or 5 to 10-membered heteroaryl which is optionally substituted, etc., B is C3-11 cycloalkylene, etc., D is C6-14 aryl or 5 to 10-membered heteroaryl which is optionally substituted, etc.

Abstract: There is provided a novel triazinone compound that has an excellent T-type voltage-dependent calcium channel inhibitory activity and is specifically useful for treatment of pain. A compound of Formula (I), a tautomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof: where each substituent is defined in detail in the description or claims, for example R1 is H or C1-6 alkoxy, etc., each of L1 and L2 is independently a single bond or NR2, etc., L3 is C1-6 alkylene, etc., A is C6-14 aryl or 5 to 10-membered heteroaryl which is optionally substituted, etc., B is C3-11 cycloalkylene, etc., D is C6-14 aryl or 5 to 10-membered heteroaryl which is optionally substituted, etc.

Abstract: A washing device includes a container (10) in which aqueous solution is contained, an adsorption electrode (11) which is placed in the container (10) and on which adsorption and desorption of ions in the aqueous solution can be brought about, a counter electrode (12) which is placed in the container (10) so as to face the adsorption electrode (11), a direct-current power source (20) for applying a voltage between the adsorption electrode (11) and the counter electrode (12), and a switching circuit (30) for switching polarity of the voltage applied between the adsorption electrode (11) and the counter electrode (12).

Abstract: To provide a new technique by which efficient transfection is ensured in delivering a target gene into a cell, disclosed is a nucleic acid construct for nuclear import, which comprises a ternary complex consisting of a nucleic acid substance containing a gene to be delivered into the nucleus of a cell, an importin protein (for example, importin-?) capable of passing through the nuclear pore and involved in the nuclear transport, and a binding substance (for example, polyethyleneimine) bound to both of the nucleic acid substance and the importin protein. Nucleic acid transport from outside of a cell into the cell nucleus can be particularly promoted by administering the nucleic acid construct bound to a cell membrane receptor binding factor and/or a membrane fusing substance, or administering the nucleic acid construct encapsulated in a non-viral vector (for example, Sendai virus envelope) having cell membrane permeability and membrane fusing properties.

Abstract: To provide a new technique by which efficient transfection is ensured in delivering a target gene into a cell, disclosed is a nucleic acid construct for nuclear import, which comprises a ternary complex consisting of a nucleic acid substance containing a gene to be delivered into the nucleus of a cell, an importin protein (for example, importin-?) capable of passing through the nuclear pore and involved in the nuclear transport, and a binding substance (for example, polyethyleneimine) bound to both of the nucleic acid substance and the importin protein. Nucleic acid transport from outside of a cell into the cell nucleus can be particularly promoted by administering the nucleic acid construct bound to a cell membrane receptor binding factor and/or a membrane fusing substance, or administering the nucleic acid construct encapsulated in a non-viral vector (for example, Sendai virus envelope) having cell membrane permeability and membrane fusing properties.