Abstract: Amorphous solids of macrolide antibiotics which are stable with the passage of time are prepared by dissolving a macrolide antibiotic and a cellulose polymer selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose as a stabilizing substance in a volatile organic solvent selected from the group consisting of dichloromethane, 1,1,1-trichloroethane and chloroform and spray drying the resulting solution.

Abstract: A process for preparing preparations for oral administration which do not have a bitter taste which comprises either dissolving a bitter taste-masking substance at a high concentration in a solvent to be used for dissolving or suspending a bitter active ingredient and adding the active ingredient to the resulting solution followed by kneading, or kneading a solution or suspension in which a bitter active ingredient has been dissolved or suspended with the bitter taste-masking substance, adding silicic acid anhydride to the resulting kneaded substance to form a powder and granulating the powder using a solution of the bitter taste-masking substance in a fluidized bed granulator.

Abstract: This invention relates to an antibiotic preparation comprising a macrolide antibiotic, which is highly stabilized against an acidic solution or acidic substance because of the presence of a polymer component incorporated with the macrolide antibiotic by specific solvent treatment, and to a process for the production of such antibiotic preparation. The antibiotic preparation of this invention overcomes the defect of macrolide antibiotics that they are easily decomposed upon contact with an acidic solution or acidic substance.

Abstract: A method for the preparation of gelatin capsules having a good disintegrating property, in which a material selected from the group consisting of a protein, an amino acid, a substance having at least one amino group, an antioxidant, monobasic sodium phosphate, and the mixture thereof is added to the encapsulated contents.