Patents by Inventor Takeshi Ohnuma

Takeshi Ohnuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Perfusate preparation for ophthalmic operation
    Patent number: 6495598
    Abstract: A one-pack preparation of irrigating solution for ocular surgery of cataract, glaucoma or intraocular lens transplantation, which is excellent in the protection of ophthalmic tissues and endothelial cells during and after the operation and has a high in vivo stability. The preparation comprises an aqueous solution containing at least one compound selected from D-3-hydroxybutyric acid and water-soluble salts thereof, at least one compound selected from water-soluble bicarbonates, phosphoric acid and water-soluble phosphates, a water-soluble calcium salt, and a water-soluble magnesium salt.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: December 17, 2002
    Assignee: Ophtecs Corporation
    Inventors: Toyoaki Yoneda, Nobuhisa Naoi, Hiroaki Miichi, Shigeru Nakamura, Toshinao Hata, Fumio Saito, Takeshi Ohnuma
  • One-pack preparation for disinfection, neutralization and cleaning of contact lenses and method of disinfection, neutralization and cleaning
    Patent number: 6258591
    Abstract: The present invention provides a combined formulation for disinfecting, neutralizing and cleaning a soft contact lens and a method using the same easily, efficiently and safely. The formulation is a one-solution type of combined formulation for disinfecting, neutralizing and cleaning a soft contact lens, which includes a first formulation that contains an iodine-based disinfectant and a proteolytic enzyme and a second formulation that contains a reducing and a foaming agent treated with a delayed release coating, and which contains a nonionic surfactant in at least one of the first and second formulations. A stained soft contact lens can be disinfected, neutralized and cleaned easily by holding it in an aqueous solution colored yellow or brown by iodine molecules and removing it from the aqueous solution after the solution becomes almost colorless.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: July 10, 2001
    Assignee: Ophtecs Corporation
    Inventors: Toyoaki Yoneda, Takashi Fujii, Mika Morita, Takeshi Ohnuma, Hiroshi Tanouchi, Shigeru Nakamura
  • 4'-demethylepipodophyllotoxin glycosides
    Patent number: 5081234
    Abstract: The present invention relates to antitumor 4'-demethylepipodophyllotoxin glycosides having the formula ##STR1## wherein R is a pentose selected from the group consisting of .beta.-D-ribopyranosyl, peracyl .beta.-D-ribopyranosyl, .beta.-D-xylopyranosyl, peracyl .beta.-D-xylopyranosyl, .alpha.-D-xylopyranosyl, peracyl .alpha.-D-xylopyranosyl, .alpha.-D-arabinopyranosyl, 3,4-O-(C.sub.1-4)alkylidene-D-ribopyranosyl, 2-O-acyl-3,4-O-(C.sub.1-4)alkylidene-D-ribopyranosyl, and .beta.-D-ribofuranosyl; P is hydrogen, or --PO.sub.3 H.sub.2 or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 30, 1990
    Date of Patent: January 14, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Takeshi Ohnuma, Rika Obata
  • Epipodophyllotoxin altroside derivatives
    Patent number: 5066645
    Abstract: The present invention provides antitumor 4'-Demethylepipodophyllotoxin glycosides characterized by the fact that the glycoside moiety is altrose.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: November 19, 1991
    Assignee: Bristol-Myers Company
    Inventors: Takeshi Ohnuma, Hideaki Hoshi, Hideo Kamei, Takayuki Naito
  • Acylated derivatives of etoposide
    Patent number: 5036055
    Abstract: The epipodophyllotoxin glucosides disclosed are acylated at herein one or both sugar hydroxyl groups. These compounds exhibit significant activity against P388 murine leukemia.
    Type: Grant
    Filed: June 7, 1989
    Date of Patent: July 30, 1991
    Assignee: Bristol-Myers Company
    Inventors: Takeshi Ohnuma, Rika Obata, Hideo Kamei, Takayuki Naito
  • Alkoxymethylidene epipodophyllotoxin glucosides
    Patent number: 5034380
    Abstract: Novel cyclic orthoesters and orthocarbonates of 4'-demethylepipodophyllotoxin glucoside are disclosed in the present invention. These compounds are active against experimental murine P388 leukemia.
    Type: Grant
    Filed: November 20, 1989
    Date of Patent: July 23, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Takeshi Ohnuma, Takayuki Naito, Hideo Kamei
  • Epipodophyllotoxin glycosides
    Patent number: 4997931
    Abstract: The present invention relates to novel antitumor compounds which are 4'-demethylepipodophylloxtoxin derivatives. More particularly, the novel compounds are 4'-demethylepipodophyllotoxin allopyranosides, allofuranosides, and mannopyranosides.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: March 5, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Takeshi Ohnuma, Hideaki Hoshi
  • Fluoro-substituted epipodophyllotoxin glucosides
    Patent number: 4912204
    Abstract: The present invention provides antitumor fluoro-substituted 4'-demethylepipodophyllotoxin glucosides.
    Type: Grant
    Filed: September 6, 1988
    Date of Patent: March 27, 1990
    Assignee: Bristol-Myers Company
    Inventors: Takeshi Ohnuma, Tetsuro Yamasaki, Hideo Kamei, Takayuki Naito