Abstract: Alleviation of vascular disorder such as vasculitis or angialgia is required in the use of a water-soluble drug causing vascular disorder. According to the present invention, a composition containing a water-soluble drug causing vascular disorder; a solution for use in preparation of an administration solution containing a water-soluble drug causing vascular disorder; and a kit including a water-soluble drug preparation causing vascular disorder and the aforementioned solution, each of which contains a nonionic surfactant in an amount necessary for alleviation of vascular disorder, are provided.

Abstract: A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.

Abstract: A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.

Abstract: [Problems] To provide a novel taxane derivative which can release the medicinal substance in a bioenzyme-independent manner, is expected to have an effective therapeutic efficacy, and has a water-solubility. [Means for Solving Problems] Disclosed is a polymer conjugate of a taxane, which comprises a polymer having a polyethylene glycol moiety and two or more succinic acid monoamide moieties and a taxane, wherein a carboxylate group in the polymer and an alcoholic hydroxyl group in the taxane are bound to each other via an ester bonding.

Abstract: A vending machine has a support part that has a first support member extending in the right and left direction on the inside of a commodity storage chamber and a second support member extending in the front and rear direction on the inside of the commodity storage chamber, and supports a commodity column so that the commodity column is movable in the front and rear direction on the first and second support members. In the vending machine, when a support receiving part is detached from the first support member, the commodity column can be moved in the front and rear direction via the second support member, so that replenishment of commodities to the commodity column and maintenance of the commodity column can be accomplished. Both of the first support member and the second support members are located under the commodity column, and support the commodity column from the downside. Therefore, spaces for arranging support members at the right and left of the commodity column are unnecessary.

Abstract: [Problems] To provide a novel taxane derivative which can release the medicinal substance in a bioenzyme-independent manner, is expected to have an effective therapeutic efficacy, and has a water-solubility. [Means for Solving Problems] Disclosed is a polymer conjugate of a taxane, which comprises a polymer having a polyethylene glycol moiety and two or more succinic acid monoamide moieties and a taxane, wherein a carboxylate group in the polymer and an alcoholic hydroxyl group in the taxane are bound to each other via an ester bonding.

Abstract: The invention provides a beverage extractor permitting extraction of a beverage of high quality irrespective of its type. The extractor is provided with a first extraction channel for letting the beverage extracted in a cylinder flow into the extraction pipe via beverage outlet holes of a second piston having a prescribed first bore and a second extraction channel via a communication hole having a prescribed second bore, which is smaller in bore than the outlet holes, for letting the beverage extracted in the cylinder flow into the extraction pipe, and the first and second extraction channels are switched over between each other by the movement of the second piston. This makes it possible to select an extraction channel suitable for the type of beverage, whether regular coffee or espresso coffee, and accordingly to extract a beverage of high quality irrespective of the type of beverage.

Abstract: A derivative of a cytidine metabolic antagonist which can exert a high therapeutic effect at a low dose. A polymeric derivative of a cytidine metabolic antagonist which comprises a polymeric compound having a polyethylene glycol moiety and a polymer moiety having a carboxyl group in a side chain and a cytidine metabolic antagonist, which has such a structure that the carboxyl group in the side chain of the polymeric compound and an amino group in the cytidine metabolic antagonist are bound together to form an amide bond.

Abstract: [PROBLEMS] To provide a derivative of a cytidine metabolic antagonist which can exert a high therapeutic effect at a low dose. [MEANS FOR SOLVING PROBLEMS] A polymeric derivative of a cytidine metabolic antagonist which comprises a polymeric compound having a polyethylene glycol moiety and a polymer moiety having a carboxyl group in a side chain and a cytidine metabolic antagonist, which has such a structure that the carboxyl group in the side chain of the polymeric compound and an amino group in the cytidine metabolic antagonist are bound together to form an amide bond.

Abstract: A vending machine has a support part that has a first support member extending in the right and left direction on the inside of a commodity storage chamber and a second support member extending in the front and rear direction on the inside of the commodity storage chamber, and supports a commodity column so that the commodity column is movable in the front and rear direction on the first and second support members. In the vending machine, when a support receiving part is detached from the first support member, the commodity column can be moved in the front and rear direction via the second support member, so that replenishment of commodities to the commodity column and maintenance of the commodity column can be accomplished. Both of the first support member and the second support members are located under the commodity column, and support the commodity column from the downside. Therefore, spaces for arranging support members at the right and left of the commodity column are unnecessary.

Abstract: A commodity column for a vending machine in which commodities are arranged in a front-rear direction, a plurality of the commodity columns being placed in a left-right direction in a commodity accommodation chamber, the commodity column having commodity passage members each having a side wall extending in the front-rear direction and a bottom extending from the side wall in one direction along the left-right direction, the commodity passage members being capable of being connected to each other through an extending end of the bottom, and a passage side member capable of being connected to the extending end of the bottom of the commodity passage member. A plurality of the commodity passage members are placed one after another in one direction along the left-right direction, each adjacent pair of the commodity passage members being connected to each other through the extending end.

Abstract: The present invention provides a commodity carrying out device that can reliably carry out even a commodity with a vertically long shape to a predetermined commodity carrying out position without producing a carrying-out failure. That is, when a bucket unit that receives a commodity is moved in a width direction towards a predetermined commodity carrying out position, the commodity is retained in an inclined state. It is thus possible to retain the commodity in a stable posture in the bucket unit that moves towards the predetermined commodity carrying out position, and even when carrying out a commodity that has a vertically long shape, the commodity can be reliably carried out to the commodity outlet portion without producing a carrying-out failure.

Abstract: The present invention provides a commodity carrying out device that can reliably carry out a vertically-long shaped commodity in an upright state from a commodity storage column to a bucket. More specifically, since a commodity positioned at the front end side of a commodity storage column is tilted forward to be moved into a bucket, when moving a vertically-long shaped commodity in an upright state into a bucket, it is possible to move the commodity without the commodity toppling backwards. Thus, the commodity can be reliably moved into the bucket.

Abstract: The invention provides a beverage extractor permitting extraction of a beverage of high quality irrespective of its type. The extractor is provided with a first extraction channel for letting the beverage extracted in a cylinder flow into the extraction pipe via beverage outlet holes of a second piston having a prescribed first bore and a second extraction channel via a communication hole having a prescribed second bore, which is smaller in bore than the outlet holes, for letting the beverage extracted in the cylinder flow into the extraction pipe, and the first and second extraction channels are switched over between each other by the movement of the second piston. This makes it possible to select an extraction channel suitable for the type of beverage, whether regular coffee or espresso coffee, and accordingly to extract a beverage of high quality irrespective of the type of beverage.

Abstract: A serpentine-type merchandise storing and dispensing column used for an automatic vending machine has a pair of opposing, generally vertically disposed wave-formed walls forming a serpentine merchandise storing space therebetween. Each wall includes a plurality of arcuate boards pivotally coupled to a frame and are disposed generally vertically in succession. The arcuate boards of one wall are disposed in a staggered arrangement with respect to the levels of the arcuate boards of the opposing wall. Each arcuate board is urged by a tension-spring so as to pivotally swing into the serpentine merchandise storing space. Thus, the board cushions descending merchandise in the serpentine merchandise storing space. Each arcuate board has a plurality of vibration absorbing slots and a plurality of beads between, and in parallel with, the slots.