Abstract: A plastic encapsulated semiconductor light emitting device comprises a plurality of leads 1, 2, one of which is formed with a dished portion 5; a semiconductor light emitting element 3 attached on a bottom surface 6 of the dished portion 5 for electrical connection of the light emitting element across the plurality of leads 1, 2; a plastic encapsulant 9 for sealing each end of the leads 1, 2, and the semiconductor light emitting element 3; a light-permeating cover 20 attached to an outer surface of the plastic encapsulant 9; and fluorescent particles 16 contained in the cover 20. As the number of fluorescent particles 16 at the vertex of the upper portion 22 is larger than that of the fluorescent particles 16 in the cylindrical lower portion 21, the semiconductor light emitting device can emit light with the nearly uniform light wavelength at any angular distance from the central axis of the plastic encapslant 9.

Abstract: In a solid-state imaging device and its production method according to the present invention, a solid-state image sensor has an effective light-receiving region on a circuit formation surface provided in a face-down condition. A transparent substrate has a conductor pattern provided thereon to confront the circuit formation surface of the image sensor. A transparent adhesive agent is provided between the image sensor and the substrate and formed into a thin layer, the adhesive agent covering the light-receiving region of the image sensor. A plurality of bumps are provided on one of the image sensor and the substrate to interconnect the image sensor and the conductor pattern of the substrate.

Abstract: A light permeable fluorescent cover 6 is provided that comprises a fluorescent material 7 contained in the cover 6 attached on a light emitting diode for emitting a first light with a first peak in blue wavelength range of 420 nm to 480 nm. The fluorescent material 7 emits a second light with a second peak in green wavelength range of 480 nm to 580 nm separated from the first peak and a third light with a third peak in red wavelength range of 580 nm to 750 nm separated from the second peak to synthesize lights in a wide chromaticity area by mixing three primary blue, green and red lights and to irradiate them to outside of the cover 6 in colorful expression.

Abstract: The present invention generally relates to high density nucleic acid arrays and methods of synthesizing nucleic acid sequences on a solid surface. Specifically, the present invention contemplates the use of stabilized nucleic acid primer sequences immobilized on solid surfaces, and circular nucleic acid sequence templates combined with the use of isothermal rolling circle amplification to thereby increase nucleic acid sequence concentrations in a sample or on an array of nucleic acid sequences.

Abstract: Streptavidin-metallothionein chimeric proteins with biological recognition specificity in which the streptavidin moiety provides high affinity biotin binding and the metallothionein moiety provides a high affinity metal binding. The binding affinity of the streptavidin-metallothionein chimeric protein both for biotin and heavy metal ions allows specific incorporation into, conjugation with, or labelling of any biological material containing biotin with various heavy metal ions.

Abstract: Compounds and methods are described for producing streptavidin mutants with changed affinities. In particular, modifications to the sequence of the natural streptavidin gene is described to create amino acid substitutions resulting in greater affinity for biotin substitutes than for biotin.

Abstract: In an organic electroluminescent device constructed by providing at least an emitting layer using an organic material between a hole injection electrode and an electron injection electrode, in forming an emitting layer having a dopant doped into a host material, a dopant having a condensed ring obtained by condensing three or more rings is used, and the difference between the highest occupied molecular orbital in the host material and the highest occupied molecular orbital in the dopant is in a range from −0.3 eV to +0.3 eV.

Abstract: Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin. The general requirement for biotin through the living world makes streptavidin-based conditional lethal designs applicable to a broad range of containment strategies.

Abstract: The present invention generally relates to high density nucleic acid arrays and methods of synthesizing nucleic acid sequences on a solid surface. Specifically, the present invention contemplates the use of stabilized nucleic acid primer sequences immobilized on solid surfaces, and circular nucleic acid sequence templates combined with the use of isothermal rolling circle amplification to thereby increase nucleic acid sequence concentrations in a sample or on an array of nucleic acid sequences.

Abstract: A novel liquid crystal display apparatus includes a substrate kit and an assembling member. The substrate kit includes first and second polymer substrates on which electrodes are mounted and which are deposited in parallel in a horizontal direction such that the electrodes face each other. A sealing member is deposited around a circumference of the first and second polymer substrates such that a sealed space is made by the electrodes and the sealing member. The first polymer substrate forms a substrate extension extending outwards in a horizontal plane and the electrode bonded on the first polymer substrate forms an electrode extension extending along the substrate extension. The substrate kit further includes liquid crystal sealed inside the sealed space, polarizing seals bonded on each of the pair of polymer substrates on sides opposite to the sides having the electrodes, and an assembling member on which the substrate kit is mounted.

Abstract: The present invention relates to methods for contacting biological targets using a mutated streptavidin protein having a reduced affinity for biotin.

Abstract: Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin. The general requirement for biotin through the living world makes streptavidin-based conditional lethal designs applicable to a broad range of containment strategies.

Abstract: The present invention relates to streptavidin proteins and peptides having a altered physical properties such as an increased stability or increased or decreased affinity for binding biotin. The invention also relates to methods for the detection, identification, separation and isolation of targets using streptavidin proteins or peptides. Streptavidin with increased or reduced affinity allows for the use of the streptavidin-biotin coupling systems for detection and isolation systems wherein it is necessary to remove of one or the other of the binding partners. Such systems are useful for the purification of functional proteins and viable cells. The invention also relates to nucleic acids which encode these streptavidin proteins and peptides and to recombinant cells such as bacteria, yeast and mammalian cells which contain these nucleic acids.

Abstract: This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discrete packages. That information can be used for the detection, identification, purification and complete or partial sequencing of a particular target nucleic acid. When coupled with a ligation step, these methods can be performed under a single set of hybridization conditions. The invention also relates to the replication of probe arrays and methods for making and replicating arrays of probes which are useful for the large scale manufacture of diagnostic aids used to screen biological samples for specific target sequences. Arrays created using PCR technology may comprise probes with 5'- and/or 3'-overhangs.

Abstract: The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.

Abstract: In an organic electroluminescent device according to the present invention, at least a luminescent layer using an organic material is provided between a hole injection electrode and an electron injection electrode, and a luminescent material composed of a condensed polycyclic aromatic compound having condensed rings each having a benzene ring as a basic unit the number of which is in the range of 2 to 10, along with an organic material having hole transporting characteristics, is contained as the organic material in the luminescent layer.

Abstract: The invention relates to the replication of probe arrays and methods for replicating arrays of probes which are useful for the large scale manufacture of diagnostic aids used to screen biological samples for specific target sequences. Arrays created using PCR technology may comprise probes with 5'- and/or 3'-overhangs.

Abstract: In an organic electroluminescent device according to the present invention, at least a carrier transporting layer and a luminescent layer using an organic material are laminated between a hole injection electrode and an electron injection electrode, and a chelate compound, indicated by the following chemical formula, having as a ligand a heterocyclic compound is contained in at least one of the carrier transporting layer and the luminescent layer: ##STR1## In the foregoing chemical formula, X and Z are any elements selected from C, S, Se, Te, N and P, Y is any one element selecting from C, N and P, (A1) is an aromatic radical or a heterocyclic radical in which a hydroxyl group is bound to the Y in an ortho position, and (A2) is a radical which is bound to carbon to which the X is bound and carbon to which the Z is bound to constitute an aromatic compound or a heterocyclic compound.

Abstract: In an organic electroluminescent device according to the present invention, at least a carrier transporting layer and a luminescent layer which use an organic material are provided between a hole injection electrode and an electron injection electrode, and at least one of a compound having a pyrimidine ring as its center skeleton and a compound having a triazine ring as its center skeleton is used for a hole transporting material in a hole transporting layer in the carrier transporting layer and the organic material in the luminescent layer.

Abstract: In an organic electroluminescent device according to the present invention, at least a carrier transporting layer and a luminescent layer which use an organic material are provided between a hole injection electrode and an electron injection electrode, wherein a luminescent portion having a luminescent peak wavelength different from a luminescent peak wavelength in the luminescent layer is partially provided in such a manner that it is laminated on the luminescent layer, or at least a hole transporting layer having luminous characteristics and an electron transporting layer having luminous characteristics which respectively contain organic materials emitting fluorescence in different colors in a visible region are provided between the hole injection electrode and the electron injection electrode, wherein a hole transporting portion having non-luminous characteristics is partially provided between the hole transporting layer having luminous characteristics and the electron transporting layer having luminous ch