Patents by Inventor Takeshi Shimomura
Takeshi Shimomura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5071537Abstract: A miniature, solid-state long-life reference electrode in which the amount of outflow of an internal electrolyte containing a halogen ion is reduced includes a conductor on the periphery of which is formed a sintered body consisting of a silver halide and silver oxide, a water-containing gel enveloping the conductor and including a halogen ion electrolyte, and a hollow tubular body closed by a liquid-junction portion comprising a porous ceramic, or by a partitioning wall having an ion permeable portion of a predetermined diffusion coefficient and volume. In another embodiment, the tubular body of the reference electrode is partitioned by a partitioning wall having an ion permeable portion of a predetermined diffusion coefficient and volume.Type: GrantFiled: May 8, 1989Date of Patent: December 10, 1991Assignee: Terumo Kabushiki KaishaInventors: Shuichiro Yamaguchi, Norihiko Ushizawa, Takeshi Shimomura
-
Patent number: 5066383Abstract: A reference electrode for generating a reference potential on an ion sensor is disclosed. The reference electrode has a lamination film covering a surface of an electrically conductive substrate and formed by alternately laminating silver halide thin films and hydrophobic resin thin films.Type: GrantFiled: October 26, 1989Date of Patent: November 19, 1991Assignee: Terumo Kabushiki KaishaInventors: Shuichiro Yamaguchi, Takeshi Shimomura, Naoto Uchida, Teruaki Katsube, Noboru Oyama
-
Patent number: 5061976Abstract: The surface of a gate insulating membrane of an ion-selective field-effect transistor (ISFET) (10) is coated with a carbon thin membrane (4), and the surface of the latter is coated with an electrolytic polmerization membrane (3) of 2,6 xylenol. The ISFET obtained exhibits hydrogen-ion selectivity, little drift, high stability and little response to light. If the surface of the electrolytic polmerization membrane (3) of 2,6 xylenol is coated with another ion-selective membrane or enzyme-active membrane, various ions and the concentration of a biological substrate can be measured.Type: GrantFiled: April 19, 1991Date of Patent: October 29, 1991Assignee: Terumo Kabushiki KaishaInventors: Takeshi Shimomura, Shuichiro Yamaguchi, Takanao Suzuki, Noboru Oyama
-
Patent number: 5001531Abstract: A functional elemental device and an FET sensor provided with the same, formed by forming a conductive carbide layer between the substrate and a conductive carbon material layer, and organic thin films and were formed on the surface of said conductive carbon material layer.Thereby, the adhesiveness between the substrate and the conductive carbon material layer can be remarkably improved, and peeling does not occur in the case of electrolytic polymerization reaction and film formation, and since the interstitial ions and the like from the substrate can be prevented, the lowering of the function can be prevented, and therefore, there is attained such an effect that the preparation of a thin film covered electrode becomes possible.Type: GrantFiled: May 8, 1990Date of Patent: March 19, 1991Assignee: Terumo Kabushiki KaishaInventors: Shuichiro Yamaguchi, Takeshi Shimomura
-
Patent number: 4981570Abstract: The surface of an electrically conductive substrate (1) is provided with a redox layer (5) by an electrolytic polymerization process, and the surface of the resulting member is further provided with an ion carrier membrane (6) which includes polyvinyl chloride, a plasticizer and an ion carrier, thereby forming an ion sensor. Used as the plasticizer is one selected from among phthalate plasticizers, maleate plasticizers, adipate plasticizers, carboxylate plasticizers and polycaprolactone plasticizers, or one selected from among plasticizers comprising modified ethylene - vinyl acetate copolymer. The ion sensor obtained has low solubility in the plasticizer of the redox layer and therefore is highly stable. Since the ion sensor has little toxicity, it can be used in vivo. A preferred plasticizer is benzopohenon-tetracarboxylic under cyclic acid.Type: GrantFiled: August 7, 1989Date of Patent: January 1, 1991Assignee: Terumo Kabushiki KaishaInventors: Shuichiro Yamaguchi, Takanao Suzuki, Norio Daikuhara, Takeshi Shimomura, Noboru Oyama
-
Patent number: 4968400Abstract: PCT Filed Nov. 19, 1987 PCT Pub. No. WO88/04050 PCT Pub. Date Jun. 2, 1988.An insulative substrate (1) is coated with an electrically conductive layer (2) and a redox layer (3) which comprises an electrolytic polymerization film of 2,6-dimethylphenol, and the surface of the redox layer is provided with an enzyme-fixed (7). The enzyme electrode thus obtained exhibits a potentiometric response, and the enzyme-fixed layer has a strong adhesion. As a result, sensitivity is high, there is little drift and service life is prolonged. An ion-selective field-effect transistor can be used instead of the insulative substrate (1).Type: GrantFiled: July 19, 1989Date of Patent: November 6, 1990Assignee: Terumo Kabushiki KaishaInventors: Takeshi Shimomura, Shuichiro Yamaguchi, Naoto Uchida
-
Patent number: 4957615Abstract: An oxygen sensor includes an electrically conductive substrate directly coated with an electrolytic oxidative polymeric membrane, which contains a porphyrin compound and a metal complex thereof. Also provided is an oxygen sensor capable of being subjected to a temperature calibration and including an oxygen electrode consisting of an electrically conductive substrate directly coated with a porphyrin derivative compound and a metal complex compound thereof, a reference electrode, a gelled polymeric electrolyte in which the oxygen electrode and reference electrode are immersed, and an oxygen-selective permeable membrane coating the gelled polymeric electrolyte. The electrically conductive substrate according to the present invention is formed from a material inactive with oxygen gas, such as indium tin oxide, iridium oxide, nickel or gold.Type: GrantFiled: August 4, 1988Date of Patent: September 18, 1990Assignee: Terumo Kabushiki KaishaInventors: Norihiko Ushizawa, Takeshi Shimomura
-
Patent number: 4927516Abstract: Disclosed is an enzyme sensor for measuring a predetermined substrate concentration by potentiometric or amperometric response on the basis of an enzyme. In one aspect, a solid-state enzyme sensor measures a predetermined substrate concentration by potentiometric response and includes a solid enzyme membrane-coated electrically conductive base, redox layer or ion-sensitive layer. In another aspect, a solid-state enzyme sensor measures a predetermined substrate concentration by amperometric response and includes a solid enzyme membrane-coated oxygen reduction catalyst layer. Also disclosed is an enzyme control layer for controlling the outflow and inflow of the enzyme layer.Type: GrantFiled: June 24, 1987Date of Patent: May 22, 1990Assignee: Terumo Kabushiki KaishaInventors: Shuichiro Yamaguchi, Naoto Uchida, Takeshi Shimomura, Noboru Oyama
-
Patent number: 4871442Abstract: An ion sensor includes an electrically conductive substrate, a redox layer coating the surface of the electrically conductive substrate, a barrier layer coating the surface of the redox layer, and an ion-selective layer coating the surface of the barrier layer. The barrier layer functions to prevent migration between the ion-selective layer and redox layer of substances constituting these layers, and to transmit a potential difference produced in the ion-selective layer by contact with an ion from the ion-selective layer to the redox layer.Type: GrantFiled: April 29, 1987Date of Patent: October 3, 1989Assignee: Terumo CorporationInventors: Shuichiro Yamaguchi, Norio Daikuhara, Takeshi Shimomura
-
Patent number: 4861454Abstract: An oxygen sensor includes an electrically conductive substrate directly coated with an electrolytic oxidative polmeric membrane, which contains a porphyrin compound and a metal complex thereof. Also provided is an oxygen sensor capable of being subjected to a temperature calibration and including an oxygen electrode consisting of an electrically conductive substrate directly coated with a porphyrin derivative compound and a metal complex compound thereof, a reference electrode, a gelled polymeric electrolyte in which the oxygen electrode and reference electrode are immersed, and an oxygen-selective permeable membrane coating the gelled polymer electrolyte.Type: GrantFiled: September 12, 1988Date of Patent: August 29, 1989Assignee: Terumo Kabushiki KaishaInventors: Norihiko Ushizawa, Takeshi Shimomura
-
Patent number: 4839020Abstract: A gas sensor includes a multi-layered solid-state pH electrode and a reference electrode coated with a gas-sensitive layer (solid-state or gel-state) sensitive to an ion of interest, the surface of the combination being coated with a gas-permable layer. Also provided in a gas sensor having a pH electrode and a reference electrode immersed in a gas-sensitive solution within a gas-permeable layer. Preferably, a fixed distance is maintained between a sensitive portion of the pH electrode, a sensitive portion of the reference electrode and the gas-permeable layer isolated by means of a porous layer. In another emodiment, the gas sensor incorporates a common electrode and a thermister for temperature calibration.Type: GrantFiled: May 22, 1987Date of Patent: June 13, 1989Assignee: Terumo Kabushiki KaishaInventors: Shuichiro Yamaguchi, Norio Daikuhara, Takeshi Shimomura
-
Patent number: 4816118Abstract: An ion-sensitive FET sensor has a MOSFET gate isolating membrane whose surface is covered by an ion-sensitive layer. A redox layer having a redox function is provided between the isolating membrane and the ion-sensitive layer to improve operating stability and speed of response. An electrically conductive layer or a combination of a thin metal film and an electrically conductive layer is provided between the isolating membrane and the redox layer to further improve operating stability, the adhesion of the layers and the durability of the sensor. Also disclosed are optimum materials for use as an ion carrier employed in the ion-sensitive layer.Type: GrantFiled: June 2, 1988Date of Patent: March 28, 1989Assignee: Terumo CorporationInventors: Noboru Oyama, Takeshi Shimomura, Shuichiro Yamaguchi
-
Patent number: 4798664Abstract: Disclosed is a solid-type ion sensor which does not have an internal liquid chamber. The ion sensor has a laminated structure basically includes an electrically conductive substrate, a redox layer having a redox function covering the surface of the electrically conductive substrate, and an ion-selective layer covering the surface of the redox layer. Also provided is an ion sensor of this type having an insulated thermister imbedded so as to contact the redox layer.Type: GrantFiled: December 24, 1986Date of Patent: January 17, 1989Assignee: Terumo Kabushiki KaishaInventors: Shuichiro Yamaguchi, Norihiko Ushizawa, Takeshi Shimomura
-
Patent number: 4753719Abstract: Disclosed is an ion sensor having an ion-sensitive substrate provided within a tube at a position recessed from an open end of the tube and having an ion carrier membrane, which is selectively permeable to an ion of interest, filling the space between the opening of the tube and the surface of the ion-sensitive substrate on the open-end side of the tube. A method of manufacturing the ion sensor includes steps of inserting and retaining the ion-sensitive substrate in the tube, filling the space between the ion-sensitive substrate and the tube with a sol-like ion carrier membrane composition, and gelling the sol-like ion carrier membrane composition.Type: GrantFiled: May 27, 1986Date of Patent: June 28, 1988Assignee: Terumo Kabushiki KaishaInventors: Shuichiro Yamaguchi, Takeshi Shimomura, Norihiko Ushizawa
-
Patent number: 4735832Abstract: A container made of synthetic resin and provided at one portion thereof with at least one tightly closable opening, which container has on a surface thereof a continuous coating having a gas barrier characteristic comprising low permeability to oxygen and carbon dioxide by the plasma treatment reaction of a mixture of a silicon compound having the general formula I with a silicon compound having the general formula II: ##STR1## wherein m=1-5, n=1-5, R.sup.1 and R.sup.2 are C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy or phenyl or OH.Type: GrantFiled: February 24, 1987Date of Patent: April 5, 1988Assignee: Terumo Kabushiki KaishaInventors: Toshiji Ichikawa, Yoshimitsu Asada, Ken Tatebe, Tooru Takahashi, Juuro Aoyagi, Takeshi Shimomura
-
Patent number: 4705612Abstract: In a method for plasma-initiated polymerization by the steps of exposing a vapor phase containing monomer vapor to a plasma and introducing a polymerization initiating active seed consequently produced into a condensate phase of monomer thereby effecting chain-growth polymerization of the monomer, the improvement which comprises effecting the production of the polymer while keeping a radical polymerization initiator present at least in the aforementioned vapor phase.Type: GrantFiled: February 6, 1986Date of Patent: November 10, 1987Assignee: Terumo Kabushiki KaishaInventors: Takeshi Shimomura, Tohru Takahashi
-
Patent number: 4582589Abstract: A pH sensor includes a substrate formed of an electrically conductive carbon material. A hydrogen ion-sensitive layer is formed on the substrate surface. The layer is formed of an electrooxidation polymer of a nitrogen-containing aromatic compound selected from the group consisting of 1-aminopyrene and a mixture of 1-aminopyrene and pyridine.Type: GrantFiled: June 26, 1985Date of Patent: April 15, 1986Assignee: Terumo Kabushiki KaishaInventors: Norihiko Ushizawa, Tsutomu Murakami, Takeshi Shimomura, Noboru Oyama
-
Patent number: 4579641Abstract: A pH measurement device includes working and reference electrodes. The working electrode has a linear electrically conductive substrate, at least a distal end surface of which consists of platinum, and a selective hydrogen ion permeable layer formed on the distal end face of the substrate. The reference electrode includes an electric conductor formed to be insulated from the working electrode and surrounding the working electrode, a polymer-silver (I) complex layer formed on the outer circumferential surface of the conductor, and an ion-conductive layer containing an anionic compound and formed on the complex layer. The pH of a solution is measured in accordance with a difference between a potential of the working electrode and that of the reference electrode.Type: GrantFiled: June 26, 1985Date of Patent: April 1, 1986Assignee: Terumo Kabushiki KaishaInventors: Takeshi Shimomura, Norihiko Ushizawa, Shuichiro Yamaguchi, Tsutomu Murakami
-
Patent number: 4563263Abstract: A selectively permeable film directly applied to coat the surface of an electroconductive element, said electively permeable film comprising a polymer which is derived from at least one aromatic compound selected from the group of nitrogen-containing aromatic compounds or from the group of hydroxy aromatic compounds. The nitrogen-containing aromatic compounds are aniline, 2-aminobenzotrifluoride, 2-aminopyridine, 2,3-diaminopyridine, 4,4'-diaminodiphenyl ether, 4,4'-methylenedianiline, tyramine, N-(o-hydroxybenzyl)-aniline and pyrrole. The film coated on the electrode surfaces permits selective passage of ions and the electrode can be used as an ions sensor for measuring the concentration of ions in solutions.Type: GrantFiled: January 15, 1982Date of Patent: January 7, 1986Assignee: Terumo CorporationInventors: Noboru Oyama, Hiroaki Matsuda, Eishun Tsuchida, Yukio Ohnuki, Takeshi Shimomura, Norihiko Ushizawa
-
Patent number: 4560720Abstract: Medical articles made of a resin composition comprising a polyvinyl chloride and a tetracarboxylic tetraester are provided. As examples of the tetracarboxylic tetraester are mentioned tetra(2-ethylhexyl) 3,3',4,4'-biphenylethertetracarboxylate, tetra(2-ethylhexyl) 3,3',4,4'-biphenylmethanetetracarboxylate, tetra(n-dodecyl) 2,3,3',4'-biphenyl-1,1-ethanetetracarboxylate, tetra(2-ethylhexyl) 3,3',4,4'-biphenyl-2,2-propanetetracarboxylate and the like. The tetracarboxylic tetraester is incorporated in an amount from 20 to 120, preferably from 30 to 100 parts by weight per 100 parts by weight of the polyvinyl chloride. As dissolution and migration to the surface of the article of the plasticizer tetracarboxylic tetraester are low in the medical articles, said medical articles produce no adverse effects upon body fluids such as blood when contacted. Examples of preferred medical articles are blood preservation vessels, catheters and blood transfusion sets.Type: GrantFiled: October 17, 1983Date of Patent: December 24, 1985Assignee: Terumo Kabushiki KaishaInventors: Juuro Aoyagi, Toshiji Ichikawa, Mikio Koide, Takeshi Shimomura