Abstract: A coating agent containing 1% to 7% by mass of hydroxyalkyl cellulose, relative to the total mass of the coating agent, in which the amount of a hydroxyalkyl group, relative to the total mall of the hydroxyalkyl cellulose, is more than 50% to 60% by mass, is obtained. A solid formulation is obtained by spraying the coating agent onto a plane tablet.

Abstract: An orally disintegrating tablet is obtained by dry tabletting a mixture of: hydroxyalkyl cellulose microparticles having a 50% particle size in the cumulative particle size distribution of more than or equal to 15 ?m and less than 40 ?m, and having a hydroxyalkyl group content of 40 to 80% by mass; a main drug as a pharmaceutical ingredient; and optionally, additives such as an excipient, a binder, a disintegrant, a lubricating agent, an agent for sustained release, a base material, a coloring agent, a pH adjusting agent, a pH buffer agent, a surfactant, a stabilizer, an acidulant, a flavoring agent, a fluidizing agent, a refreshing agent, a sweetener, a savoring component, and a sweetness intensifier.

Abstract: Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 ?m but less than 15 ?m are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.

Abstract: An orally disintegrating tablet is obtained by dry tabletting a mixture of: hydroxyalkyl cellulose microparticles having a 50% particle size in the cumulative particle size distribution of more than or equal to 15 ?m and less than 40 ?m, and having a hydroxyalkyl group content of 40 to 80% by mass; a main drug as a pharmaceutical ingredient; and optionally, additives such as an excipient, a binder, a disintegrant, a lubricating agent, an agent for sustained release, a base material, a coloring agent, a pH adjusting agent, a pH buffer agent, a surfactant, a stabilizer, an acidulant, a flavoring agent, a fluidizing agent, a refreshing agent, a sweetener, a savoring component, and a sweetness intensifier.

Abstract: Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 ?m but less than 15 ?m are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.

Abstract: Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 ?m but less than 15 ?m are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.

Abstract: A modified polysiloxane compound represented by formula (I): X(Y)n (I), where X represents a polymer block having a repeating unit represented by formula (II), Y represents a polymer block having a repeating unit represented by formula (III), and n represents 1 or 2, and having an X to Y weight ratio of 1/99?X/Y?90/10 and a number-average molecular weight of 1,000 to 100,000 is subjected to treat for elimination of a protecting group for a hydroxyl group by adding a non-aqueous solution containing hydrogen chloride in the presence of a non-aqueous solvent so that hydrogen chloride is 0.9 to 1.3 equivalents with respect to 1 equivalent of the repeating unit represented by formula (II).

Abstract: Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 ?m but less than 15 ?m are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.

Abstract: An object of the present invention is to provide a method for producing a polybutadiene by anionic polymerization at a low temperature, in which the microstructures thereof is controlled to polybutadienes having diverse physical properties. The present invention provides a method for producing a polybutadiene by anionic polymerization of 1,3-butadiene in the presence of a polymerization initiator and under the conditions of a reaction temperature not higher than the boiling point of butadiene, wherein the polymerization is performed in the presence of a potassium salt in an aprotic polar solvent or in a mixed solvent of an aprotic polar solvent and a nonpolar solvent. The potassium salt is preferably potassium t-butoxide, and the solvent is preferably a mixed solvent of tetrahydrofuran and hexane. The resultant polybutadiene can be used in an adhesive composition and in a plate-making material composition used for flexographic printing plates.

Abstract: A modified polysiloxane compound represented by formula (I): X(Y)n (I), where X represents a polymer block having a repeating unit represented by formula (II), Y represents a polymer block having a repeating unit represented by formula (III), and n represents 1 or 2, and having an X to Y weight ratio of 1/99?X/Y?90/10 and a number-average molecular weight of 1,000 to 100,000 is subjected to treat for elimination of a protecting group for a hydroxyl group by adding a non-aqueous solution containing hydrogen chloride in the presence of a non-aqueous solvent so that hydrogen chloride is 0.9 to 1.3 equivalents with respect to 1 equivalent of the repeating unit represented by formula (II).

Abstract: Disclosed is a method for producing a polymer through living polymerization, comprising forming an oligomer having a polymerization active end, which is an oligomer higher than an average 1.0-mer and lower than an average 4.0-mer or an average 4.0-mer, and polymerizing using the oligomer having a polymerization active end as an initiating species, wherein the acrylic acid-based polymer comprising a repeating unit derived from a poly(?-lower alkyl)acrylate, and a repeating unit derived from an (?-lower alkyl)acrylic ester represented by formula (I) wherein R1 represents a hydrogen atom or a lower alkyl group, and R2 represents an organic group having a polar group in an arm portion.

Abstract: Disclosed are an acrylic acid-based polymer which is a star polymer containing a repeating unit derived from an (?-lower alkyl)acrylic ester represented by formula (I): (wherein R1 represents a hydrogen atom or a lower alkyl group, and R2 represents an organic group having a polar group) in an arm portion; an acrylic acid-based polymer containing a repeating unit derived from an poly(?-lower alkyl)acrylic ester and a repeating unit derived from an (?-lower alkyl)acrylic ester represented by formula (I), and a method for producing a polymer through living polymerization, comprising forming an oligomer having a polymerization active end, which is an oligomer higher than an average 1.0-mer and lower than an average 4.0-mer or an average 4.0-mer, and polymerizing using the oligomer having a polymerization active end as an initiating species.

Abstract: Disclosed are an acrylic acid-based polymer which is a star polymer containing a repeating unit derived from an (?-lower alkyl)acrylic ester represented by formula (I): (wherein R1 represents a hydrogen atom or a lower alkyl group, and R2 represents an organic group having a polar group) in an arm portion; an acrylic acid-based polymer containing a repeating unit derived from an poly(?-lower alkyl)acrylic ester and a repeating unit derived from an (?-lower alkyl)acrylic ester represented by formula (I), and a method for producing a polymer through living polymerization, comprising forming an oligomer having a polymerization active end, which is an oligomer higher than an average 1.0-mer and lower than an average 4.0-mer or an average 4.0-mer, and polymerizing using the oligomer having a polymerization active end as an initiating species.

Abstract: Disclosed is a star polymer having a core part produced by anionic polymerizing one or more polyfunctional (meth)acrylic acid ester derivative represented by formula (IV) (wherein R represents a hydrogen atom, etc., n represents 2 or 3, and A represents an organic group linking at a carbon atom) in an organic solvent, in the presence of 0.1 to 0.99 mol of organic alkali metal compound with respect to 1 mol of the compound of the formula (IV), and in the presence of 0.1 to 20 mol of inorganic salts of alkali metal or alkali earth metal with respect to 1 mol of the organic alkali metal compound, and an arm part formed by anionic polymerizing from the anionic active site of the core part one or more monofunctional (meth)acrylic acid ester derivative represented by formula (I) (wherein R1 represents a hydrogen atom, etc., and R2 represents an organic group).

Abstract: Disclosed are an acrylic acid-based polymer which is a star polymer containing a repeating unit derived from an (?-lower alkyl)acrylic ester represented by formula (I): (wherein R1 represents a hydrogen atom or a lower alkyl group, and R2 represents an organic group having a polar group) in an arm portion; an acrylic acid-based polymer containing a repeating unit derived from an poly(?-lower alkyl)acrylic ester and a repeating unit derived from an (?-lower alkyl)acrylic ester represented by formula (I), and a method for producing a polymer through living polymerization, comprising forming an oligomer having a polymerization active end, which is an oligomer higher than an average 1.0-mer and lower than an average 4.0-mer or an average 4.0-mer, and polymerizing using the oligomer having a polymerization active end as an initiating species.