Abstract: The present invention relates to a method for detecting an antibody-drug-conjugate and relates to a method for determining the efficacy of an antibody-drug-conjugate with high accuracy by a quantitative technique for identifying an expression level of a target molecule in a target cell of the antibody-drug-conjugate and interactions therebetween. According to the method, visualizing a drug and an antibody, or components of an antibody-drug-conjugate, by immunostaining with a phosphor integrated dot enables detection of the antibody-drug-conjugate and the components.

Abstract: An object of the present invention is to provide a non-clinical test method which allows for the quality control of experimental animals having a transplanted tumor site, such as tumor-bearing mice, or experimental animals having a lesion site other than a transplanted a tumor site, and which is characterized by including the step of identifying, using a specimen collected from such an experimental animal, the profile of a lesion site, for example, a transplanted tumor site, of the experimental animal, by a quantitative technique.

Abstract: The present invention relates to a method relating the evaluation of tumor tissue from an experimental animal, the method including the step of measuring an amount of a substance, except for human-derived tumor cells, contained in a sample collected from a region in an experimental animal into which a human-derived tumor tissue or tumor cells have been transplanted, wherein the region contains the tumor tissue or the tumor cells.

Abstract: A driving tool including a driver configured to drive out a fastener, a piston to which the driver is connected, a cylinder in which the piston is disposed so as to be reciprocated, a head valve which is slidably mounted to an outer circumferential side of the cylinder and controls a flow of compressed air into the cylinder, and a seal portion which is provided to face an opening edge of the head valve. The seal portion includes a lip portion protruding along an outer circumferential surface of the head valve.

Abstract: The present invention relates to a method for detecting an antibody-drug-conjugate and relates to a method for determining the efficacy of an antibody-drug-conjugate with high accuracy by a quantitative technique for identifying an expression level of a target molecule in a target cell of the antibody-drug-conjugate and interactions therebetween. According to the method, visualizing a drug and an antibody, or components of an antibody-drug-conjugate, by immunostaining with a phosphor integrated dot enables detection of the antibody-drug-conjugate and the components.

Abstract: A driving tool including a driver configured to drive out a fastener, a piston to which the driver is connected, a cylinder in which the piston is disposed so as to be reciprocated, a head valve which is slidably mounted to an outer circumferential side of the cylinder and controls a flow of compressed air into the cylinder, and a seal portion which is provided to face an opening edge of the head valve. The seal portion includes a lip portion protruding along an outer circumferential surface of the head valve.

Abstract: Provided are methods of treating a mammal at risk for allograft rejection. The methods comprise treating the mammal with a compound that reduces an interaction between a CXC chemokine and a CXC receptor.

Abstract: First upsetting is conducted in which an annular sidewall part is plastically deformed outward in the radial directions by a first molding part of a punch to thereby form a first-upsetting molded part on one end. Subsequently, second upsetting is conducted in which a solid part is pressed with the punch and the solid part is plastically deformed outward in the radial directions by a split mold which is descending. Thus, the plastically deformed part comes into and fills a second molding part of the split mold to form a second-upsetting molded part on the other end in the axis direction. Simultaneously therewith, an undercut part is formed between the first-upsetting molded part and the second-upsetting molded part by an undercut-molding part of the split mold.

Abstract: A printing ink composition comprising: a vegetable oil; and a rosin-modified phenol resin having a weight average molecular weight of at least 30,000, the rosin-modified phenol resin being dissolved in the vegetable oil, wherein the printing ink composition has a content of a volatile organic solvent of not more than 3% by weight.

Abstract: A printing ink composition comprising: a vegetable oil; and a rosin-modified phenol resin having a weight average molecular weight of at least 30,000, the rosin-modified phenol resin being dissolved in the vegetable oil, wherein the printing ink composition has a content of a volatile organic solvent of not more than 3% by weight.

Abstract: A shading spacer for liquid crystal consisting of a cross-linked polymer particles containing a dyestuff which is fixed in said polymer particles by taking a dyestuff compound having a silyl group which can be hydrolyzed in said polymer particles having a silyl group which can be hydrolyzed when said polymer particles are cross-linked, is provided in the present invention. In said shading spacer, removal of dyestuff from said polymer particles is prevented.

Abstract: One or more streams of molten metal poured into a continuous casting mold are acted on magnetically by static magnetic fields, covering substantially the entire width of the casting mold, thereby reducing the speed of the molten metal streams from the immersion nozzle, unifying the flow profile of the molten metal in the mold, preventing trapping and accumulating of mold powders and inclusions into the cast products. Magnetic poles are provided which are at least as wide as or wider than the minimum width of the cast products and the iron core is arranged on the same face of the casting mold with mutually opposite polarities in the drawing direction. Even if casting conditions change from time to time, defects in final products made of the cast metal are substantially reduced.

Abstract: A logical circuit comprises a plurality of stage processing units, each of which includes a logical operation processing unit and a carry signal transmission controlling unit. The logical operation processing unit carries out a logical operation process of plural bits of input data, and the carry signal transmission controlling unit controls transmission of a carry signal which is supplied from a carry signal transmission controlling unit of the preceding stage of the stage processing unit. In this structure, the logical operation process is carried out with every group of plural bits of the input data, and the carrying signal is transmitted through the stage processing units which are less in number than that of a conventional logical circuit, so that the processing time of the logical circuit is shortened.

Abstract: A multi-spindle synchronous drive unit for synchronously driving a plurality of spindles, includes a plurality of motors for respectively driving the spindles, a plurality of encoders for respectively detecting rotational positions of the motors, a plurality of phase locked loop control units for respectively controlling a drive of the motors and for receiving as feedback signals detection signals respectively output by the encoders, a reference pulse oscillator for outputting a pulse signal, and a plurality of multipliers for multiplying the pulse signal by multiplication factors respectively corresponding to rotational speed ratios of the spindles and for respectively outputting speed command pulse signals to the phase locked loop control unit.